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cells

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Cell Theory (Hooke)=   Cells are building blocks of all plants & animals All cells come from the division of preexisting cells. Cells are the smallest units that perform all vital physiological functions. Each cell maintains homeostasis at the cellular level.  
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Sex cells:   germ cells or reproductive cells; either sperm or oocytes  
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Somatic cells:   all other cells (excludes only sex cells)  
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functions of plasma membrane   Physical Isolation Regulation of exchange with the environment Sensitivity to the environment Structural support  
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Integral proteins:   part of the membrane structure & cannot be removed without damaging or destroying the membranes; most span the width of the membrane one or more times, thus are known as transmembrane proteins.  
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receptor proteins   in the membrane are sensitive to the presence of specific extracellular molecules called ligands.  
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Glycocalyx:   layer formed by the extension of the carbohydrate portion beyond the outer surface of the membrane.  
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cytoplasm   general term for the material located between the plasma membrane & membrane surrounding the nucleus; contains many more proteins than the extracellular fluid; contains organelles & cytosol.  
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cytosol vs extracellular fluid   Concentration of potassium ions higher in the cytosol Fluid&concentration of sodium ions is lower Concentration of proteins is higher in cyto and contains small amounts of carb & AA,lipids ECF is a transport medium only & no reserves are there.  
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interstitial fluid) *which is in both cytosol and extracellular fluid within tissue   contain masses of insoluble materials known as inclusions; most common inclusions are nutrients such as glycogen.  
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Nonmembranous organelles:   not completely enclosed by membranes & all their components are in direct contact with the cytosol; cytoskeleton, microvilli, centrioles, cilia, ribosomes, proteasomes.  
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Microtubules   found in most cells; hollow tubes built from globular protein tubulin;  
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tubulin is a ____ protein that   builds up microtubules  
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Fixed ribosomes   are attached to the endoplasmic reticulum (ER).  
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Smooth ER:   refers to the fact that no ribosomes are associated  
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ribosomes associated with the rough ER surface are   fixed ribosomes;  
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Golgi Apparatus:   looks like a stack of dinner plates; receives transport vesicles from the ER; typically consists of 5 or 6 flattenedmembranous sacs (cisternae); single cells may have several oftennear the nucleus  
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functions of golgi   *Modifies & packages secretions, such as hormones or enzymes for release through exocytosis *renews or modifies plasma membrane *packages special enzymes within vesicles for use in the cytoplasm.  
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lysosomes   special vesicles that provide an isolated environment for potentially dangerous chemical reactions; small dense often spherical bodies with contents that look dark & dense.  
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functions of lysosomes   fusing with membranes of damaged organelles, enzymes are activated forming secondary lysosomes which break down lysosomal contents; cytosol reabsorbs released nutrients & wastes R removed by exocytosis essential cleanup & recycling  
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Peroxisomes   smaller than lysosomes & carry different enzymes; produced by growth & subdivision of existing peroxisomes; enzymes produced at free ribosomes; transported from cytosol into peroxisomes by carrier proteins.  
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functions of peroxisomes   absorb, break down fatty acids&other organiccompounds making hydrogen peroxide potentially dangerous free radical within the peroxisome,catalase breaks down the hydrogen peroxide to oxygen & water protecting the cell from effects of free radicals produced  
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cristae   Inner membrane contains numerous folds that increase the surface area for reactions:  
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Matrix:   fluid contents of mitochondria surrounding the cristae  
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Nucleoli:   several dark-staining areas in the nucleus; synthesize ribosomal RNA; assemble ribosomal subunits that reach cytoplasm by carrier-mediated transport at the nuclear pores; composed of RNA, enzymes & proteins called histones;  
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gene   functional unit of heredity; contains all the DNA triplets needed to produce specific proteins  
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In the RNA processing, nonsense regions___________ are snipped out & remaining segments_________are spliced together.   (introns) exons  
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Selectively permeable:   because the permeability of the cell’s plasma membrane is somewhere in between, it is said to be selectively permeable; permits free passage of some materials & restricts the passage of others.  
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Freely permeable:   membrane through which any substance can pass without difficulty.  
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osmosis   \is the diffusion of water molecules across a selectively permeable  
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Isotonic:   solution that does not cause an osmotic flow of water into or out of a cell.  
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Hypotonic:   solution with the least solute concentration.  
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Hemolysis:   event of a RBC swelling with fluid so it may burst when the RBCs are placed in a hypotonic solution.  
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Hypertonic solution:   solution with the greatest solute concentration; cells places in a hypertonic solution will lose water & shrivel.  
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Crenation:   shrinking of RBCs when placed in a hypertonic solution.  
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Ion pumps:   carrier proteins which actively transport cations – Na+, K+, Ca+2, Mg+2, across plasma membranes; other specialized cells can transport I-, Cl-, Fe+2  
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Exocytosis   functional reverse of endocytosis; vesicle created inside the cell fuses with, becomes part of the plasma membrane releasing the vesicle contents into the extracellular environment  
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Transmembrane potential:   potential difference across a plasma membrane.  
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Apoptosis:   genetically controlled death of cells  
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G0:   not preparing for cell division, but performing all of the other functions appropriate for that particular type of cell.  
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G1 :   Normal cell function plus cell growth, duplication of organelles, protein synthesis  
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S:   DNA Duplication & synthesis of Histones occurs during this stage. G2: Protein synthesis  
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Metaphase   begins as the chromatids move to a narrow central zone called the metaphase plate; ends when all the chromatids are aligned in the plane of the plate.  
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Anaphase:   begins when the centromere of each chromatid pair splits & the chromatids separate; the 2 daughter chromosomes are now pulled toward opposite ends of the cell along the chromosomal microtubules.  
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Cytokinesis:   division of the cytoplasm; begins with a cleavage furrow & continues throughout Telophase; completion of cytokinesis marks the end of cell division.  
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Stem cells:   special cells that maintain cell populations through repeated cycles of celldivision. Stem cells are relatively unspecialized; only function is to produce daughter cells  
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Repressor genes:   genes that inhibit cell divison (ex, p53- ½ of all cancers are associated with abnormal forms of p53)  
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Tumor (neoplasm):   mass or swelling produced by abnormal cell growth & division  
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Benign tumor:   usually remain in the epithelium or connective tissue capsule; seldom threatens an individual’s life; can be easily removed by surgery if it disturbs surrounding tissue.  
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Metastasis:   process of malignant cells traveling to distant tissues & organs establishing secondary tumors; Makes the cancer difficult to control  
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telomeres   structures@chromosome level regulates#of cell divisions performed terminal seg of DNA w/ proteins segments bend&fold repeatedly 2 form caps @ the ends of chromosomes function 2 attach chromosomes 2 nuclear matrix  
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telomeres   2 protect ends of chromosomes from damage during mitosis r subject 2wear&tear when 2 short the repressor gene signals the cell 2 stop dividing  
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nucleoli   form around portions of DNA that contain the instructions for producing ribo proteins & RNA when those instructions of amino acids  
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function of smooth er   synthesis of phospholipids & cholesterol needed for growth & maintenance of plasma membrane, ER, nuclear envelope & Golgi apparatus Synthesis of steroid hormones ( androgens & estrogens)  
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function of smooth er   Synthesis & storage of glycerides esp triglycerides in liver cells & adipocytes. Synthesis & storage of glycogen in skeletal muscle & liver cells.  
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function of smooth er   In muscle cells, neurons, & other types of cells, SER adjusts composition of cytosol by absorbing & storing ions (ex. Ca+2) larger molecules; also, SER in liver & kidney cells, responsible for detoxification or inactivation of drugs.  
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