Infectious Disease
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| PROCESS OF COLONIZATION | PROCESS OF COLONIZATION
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| What must first occur before an organism can start making trouble? | It must first stick by evading host defense
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| What is the process of colonization? List steps | Site specificity, adherence, and microbe growth
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| What influences adhesion? | Chemical specificity
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| Define microbiota and carrier state: | Microbiota: flora; carrier state: most people will get disease, but some won't
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| Give examples of sterile sites: | Our brain, most of our body
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| MICROBE-HOST RELATIONSHIP | MICROBE HOST RELATIONSHIP
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| DEFINE NON-PARASITES: | Won't drain you of resource
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| Give examples: | Saphrocytes, Mutalism, commensial microbes
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| What are saphrocytes? | Live on dead stuff
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| Mutalism: | Both benifit
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| Commensial microbes: | Host not affected
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| Systemic: | Spread by blood of lymphatic system
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| Bacteremia: | Presence of bacteria in blodd that aren't growing
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| Septacimia: | Bacteria growing in our bodd
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| Virelemia; | Reproducing viruses in blood
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| Toximia: | Toxin in blood
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| PROCESS OF DISEASE | PROCESS OF DISEASE
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| Adhesion; | Attachment molecule
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| HARMFUL MICROBIAL PRODUCTS | HARMFUL MICROBIAL PRODUCTS
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| What are some virulence factors that are produces by the microbe? | Endotoxins and exotoxins
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| What are endotoxins? | Carbs or lipids
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| What cell type releases them? Give example: | Gram --; like the LPS and lipid A
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| What is an assay of endotoxin? | LAL Assay in lab--from horseshoe crab
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| Compositon of exo vs. endo? | Protein vs. carbs and lipids
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| Production of exo vs. endo? | Active release vs. component of cell
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| Target of exo vs. endo? | Specific (enzyme) vs. general (immune response)
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| Stability of exo vs. endo? | Not stable vs. very stable
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| From which cell type are exotoxins released? | Gram +
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| From which cell types are endotoxins released? | Gram --
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| Do we want to release endotoxins: | NO NO NO NO NO!!!!
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| What do fungi and parasites lead to? | Allergic reactions
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| Toxicity of Exo vs. endo | High tox vs. low tox
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| So, how much of a dose do you need for exo vs. endo? | low vs. high dose
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| Fever response of exo vs. endo: | No fever vs. fever
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Created by:
talkglitter2486