clinical neuro 3
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| therapeutic window for barbituates | very narrow
🗑
|
||||
| therapeutic window | difference between effective dose and deadly dose
🗑
|
||||
| onset of phenobarbital | slow
🗑
|
||||
| GABA opens.. | Cl- channels
🗑
|
||||
| MOA of barbituates | GABA agonists
🗑
|
||||
| clinical uses of secobarbital | short term insomnia, acute psychosis
🗑
|
||||
| clinical uses of phenobarbital | preoperative sedation
🗑
|
||||
| often produces hyperactivity in children | phenobarbital
🗑
|
||||
| MOA of BZs | allosterically bind to GABAa and increases GABA's effect
🗑
|
||||
| DOC for panic disorders/anxiety, esp in elderly | alprazolam
🗑
|
||||
| DOC for generalized anxiety disorder | lorazepam
🗑
|
||||
| DOC for short-term anxiety | meprobamate
🗑
|
||||
| short term sedative-hypnotic | meprobamate
🗑
|
||||
| DOCs for alcohol withdrawl | chlorazepate, chlordiazepoxide
🗑
|
||||
| used to shorten sedation for surgery | flumazenil
🗑
|
||||
| toxic effects of BZs are related to | sedative actions
🗑
|
||||
| BZs have some teratogenicity during | first trimester
🗑
|
||||
| Chance of physical dependence is high with | BZs
🗑
|
||||
| symptoms of BZ withdrawl | restlessness, anxiety, weakness, generalized seizures
🗑
|
||||
| dosing to avoid withdrawl sx with BZ | taper 25% per week to 50% of dose, then 1/8th dose every 4-7 days
🗑
|
||||
| contraindication for alprazolam | pulmonarly compromised pts
🗑
|
||||
| monitor use in depressive pts w/suicidal ideation | chlordiazepoxide
🗑
|
||||
| high doses reduce REM | meprobamate
🗑
|
||||
| associated w/congenital malformations | meprobamate
🗑
|
||||
| non-BZ used as sedative-hypnotic | zolpidem & zaleplon
🗑
|
||||
| act at GABAa type 1 only | zolpidem & zaleplon
🗑
|
||||
| non-BZ w/some anxiolytic action | zaleplon
🗑
|
||||
| stimulates GABA release | propofol
🗑
|
||||
| DOC for ambulatory surgery | propofol
🗑
|
||||
| metabolism of propofol | rapid metabolism, 99% changed before exceretion
🗑
|
||||
| pain may occur @ injection site | propofol
🗑
|
||||
| contraindicated in children due to acidosis | propofol
🗑
|
||||
| DOC for pts w/limited CV reserve (does not lower BP) | etomidate
🗑
|
||||
| recovery w/etomidate | slower than propofol
🗑
|
||||
| analgesic action of etomidate | none
🗑
|
||||
| adverse effects of etomidate | pain @ injection site, myoclonus, post-op nausea & vomitting
🗑
|
||||
| 3 sedation settings | monitored anesthesia care, conscious sedation, deep sedation
🗑
|
||||
| monitored anesthesia care | pre-midazolam IV, then propofol/ketamine/opioids
🗑
|
||||
| conscious sedations | IV diazepam, midazolam, propofol
🗑
|
||||
| deep sedation | IV thiopental, midazolam, propofol,opiods, and ketamine
🗑
|
||||
| MOA of buspirone | 5HT1A agonist, inhibits dorsal raphe and stim locus cereleus
🗑
|
||||
| buspirones & BZs | not cross-tolerant
🗑
|
||||
| clinical use of buspirone | long-term anxiety
🗑
|
||||
| effect of buspirone on NTs | dec 5HT, inc NE, inc DA
🗑
|
||||
| no potential for abuse, dependence, or withdrawal | buspirone
🗑
|
||||
| pts maintain cognitive & psychomotor skills | buspirone
🗑
|
||||
| can be used w/alcohol | buspirone
🗑
|
||||
| less effective in recent BZ users | buspirone
🗑
|
||||
| reduces visceral activity | propranolol
🗑
|
||||
| treats performance anxiety | propranolol
🗑
|
||||
| GAD, panic disorders, PTSD, social phobias, and other phobias can be treated with | SSRIs
🗑
|
||||
| anxiety + depression | mirtazapine
🗑
|
||||
| may produce slightly less locomotor disruption | bretazenil
🗑
|
||||
| non-BZ that has a similar MOA | zopiclone
🗑
|
||||
| melatonin agonist, MT1 and MT2 | ramelteon
🗑
|
||||
| shortens latency to sleep w/no rebound insomnia or withdrawl | ramelteon
🗑
|
||||
| Busiprone is aka | Buspar
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
drhermy
Popular Science sets