Drugs!
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| Prostaglandin E1 MOA | stim adenylyl cyclase, inc cAMP, relax VSM
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| Prostaglandin E1 use | treat heart defects in infants, ED
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| Milrinone MOA | PDE inhibitor, slows cAMP degradation
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| Milrinone use | Treat Failure
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| Nitroglycerine MOA | inc NO production- VSM relaxation
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| Nitroglycerine use | Treat angina, CHF, MI
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| Nitroglycerine adverse | Hypotension, contraindicated with viagra
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| Furosemide class | Diuretic (loop diuretic)- most effective
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| Furosemide use | hypertension, edema, CHF, renal failure symptoms
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| Diuretic adverse Rxn | Electrolyte disturbance
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| Acetazolamide | Diuretic (Carbonic Anhydrase Inhibitor)
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| Acetazolamide use | Hypertension, edema, CHF, renal failure symptoms
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| Hydrochlorothiazide class | Diuretic
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| Hydrochlorothiazide use | hypertension, edema, CHF, renal failure symptoms
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| Cardioactive antihypertensives | lower BP- Tx hypertension and heart failure
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| Cardioactive antihypertensive drugs | B blockers, Ca channel blockers
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| Isoproterenol | B1/B2 agonist
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| B1 agonist action | inc. cAMP, activate Ca channels- Ca influx
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| B2 agonist action | inc. cAMP, phospholamban activation, stim SERCA- Ca sequestration
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| B1 agonist use | tx. cardiogenic shock, heart failure
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| B2 agonist use | tx. asthma, emphysema
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| Dopamine MOA | dose dependent
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| low dose dopamine | dopamine receptor agonist
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| high dose dompamine | conversion to NE- a-receptor agonist
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| dopamine receptor agonist | vasodilation in renal system
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| Methotrexate MOA | dihydrofolate reductase competitive inhibitor
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| Methotrexate use | tx. cancer, autoimmune disease
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| Digoxin class | cardiac glycoside
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| Digoxin MOA | Inh. Na/Ca exchange (dec. Ca efflux), inh. Na/K ATPase (decreases gradient)
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| Digoxin use | Tx. heart failure
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| Digoxin adverse | dec. QT interva., inc. PR interval, ST depression
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| Propranolol class | Non-Selective B-antag
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| Propranolol use | Hypertension
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| B-blocker adverse | dec. exercise tolerance, bradycardia, conduction probs in heart
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| B-blocker contraindication | Heart failure
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| Acebutolol | Cardioselective B1 with ISA
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| Atenolol | Cardioselective B1 without ISA
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| Propranolol | Non-cardioselective B1/B2 without ISA
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| Pindolol | Non-cardioselective B1/B2 with ISA
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| Norepinephrine | A1 receptor agonist
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| Norepinephrine MOA | Gq activation- sm muscle contrxn
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| Norepinephrine effect | vasoconstrictor
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| Norepinephrine use | Tx. hypotension, nasal congestion
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| Clonidine class | Sympatholytic
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| Clonidine MOA | A2 agonist- inhibit vasomotor center in medulla oblongata, dec. symp activity
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| Clonidine use | tx. hypertension
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| Clonidine adverse | Can constrict coronaries (post-synaptic response)
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| Prazosin class | A1 antagonist
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| Prazosin MOA | Reduces NE/Epi binding, causing vasodilation
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| Prazosin use | tx. hypertension
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| Prazosin adverse | orthostatic hypertension
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| Captopril | ACE Inhibitor
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| Captopril MOA | Reduce Ang conversion, inhibit bradykinin degradation- vasodilation
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| Captopril use | hypertension, CHF, MI
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| Captopril adverse | Renal failure with art stenosis, bradykinin in lungs
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| Losartan class | Ang II Receptor Blocker
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| Losartan use | hypertension, CHF
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| Losartan adverse | renal failure with art stenosis
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| Nifedipine | Ca channel blocker
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| Nifedipine use | hypertension, vasospastic angina, arrhythmia
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| Nifedipine adverse | depress heart function
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| Acetominophen MOA | Inhibits COX 1 and 2- increases pain threshold and reduces fever
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| Acetominophen use | pain/fever
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| Prednisone MOA | inhibits phospholipase A2, red. inflammation
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| Prednisone use | inflammation, autoimmune disease
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| Nitroglycerine class | nitrate vasodilator
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| Nitrate MOA | inc. No production, inactivate MLCK- VSM relaxation
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| Nitrate use | angina, CHF, MI
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| Sumatriptan MOA | stim presynaptic receptors, inhibiting dural vasodilation and inflammation
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| Sumatriptan uses | Migraines/headaches
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| Nifedipine subclass | Dihydropyridine- Ca blocker
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| Verapamil | Phenylalkylamine subclass of Ca blockers
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| Verapamil | Affects heart more than BVs
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| Verapamil | potent neg chronotrope, inotrope, and dromotrope
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| Dilitiazem | Benzothiazepine subclass of Ca channel blockers
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| Dilitiazem | affects heart and BVs
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| Levosimendan | Ca Sensitizer
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| Levosimendan MOA | Inc Sens of cardiac troponin to Ca
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| Levosimendan MOA | Ca sens + PDE III inhibition- vasodilation
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| Levosimendan use | Heart failure
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| Levosimendan adverse | Hypotension and reflex tachycardia
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| Isocarboxazid | MAOI- affects NE metabolism
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| Isocarboxazid use | depression
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| Tolcapone | COMT inhibitor- affects NE metabolism
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| Tolcapone use | Parkinsons
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| Mecamylamine | Nicotinic antagonist
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| Mecamylamine | reduce BP
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| Mecamylamine use | Surgical BP control
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| Demecarium Ambenonium | Indirect cholinergic agonist (AChE inhibitor)
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| Demecarium use | open angle glaucoma, myasthenia gravis
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| Pilocarpine | Cholinomimetic- muscarinic agonist
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| Pilocarpine use | ocular hypertension, open and closed angle glaucoma
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| Tolterodine | Anticholinergic- muscarinic antagonist
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| Tolterodine use | Overactive bladder
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| Atropine | Anticholinergic- muscarinic antagonist
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| Atropine use | reduce airway secretions during intubation
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| Amphetamine | Affects NE release
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| Amphetamine use | ADHD
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| Desipramine | Affects NE Reuptake
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| Desipramine use | depression
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| Reserpine | Affects Vesicular packaging of NE
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| Reserpine use | hypertension
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| Metyrosine | affects NE synthesis
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| Metyrosine use | tx pheocromacytoma
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| B antagonist without ISA | full antagonists
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| atenolol, metoprolol | B1 (cardioselective) antagonists
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| Carvedilol, Labetolol, Nadolol, Propranolol | B1/B2 (noncardioselective) antagonist
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| B-Antagonists with ISA | Act as partial agonists
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| Acebutolol | Cardioselective B1
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| Penbutolol, Careolol, Pindolol | Non-cardioselective B1/B2
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| Terbutaline | B2 Agonist
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| Terbutaline uses | asthma, emphysema (relaxes airways)
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| Dobutamine | B1 agonist
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| Dobutamine use | Tx. Cardiac decomposition
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| Metoprolol | B1 antagonist
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| Metoprolol use | tx. hypertension
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| Yohimbine | A2 antagonist
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| Yohimbine use | Tx ED (injection), produce miosis
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| Phenylephrine | A1 agonist
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| Phenylephrine use | tx. hypotension, congestion
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| A1 receptor | high affinity for Epi
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| A2 receptor | high affinity for epinephrine
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| B1 receptor | high affinity for Isoproteronol
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| B2 receptor | high affinity for Isoproteronol
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| M2 Receptor signaling | Gi/G0- hyperpolarization and inhibition
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| M3 Receptor signaling | Gq- depolarization and excitation
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| B2 Receptor signaling | Gs- inc. adenylyl cyclase
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| A1 Receptor signaling | Gq- depolarization and excitation, Gi/0- inc PLA2
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| B1 Receptor signaling | Gs- incl adenylyl cyclase
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| A2 Receptor signaling | Gi- dec. adenylyl cyclase, G0- inh. Ca channels, inc PLC and PLA2
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