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BIO340- Chapter 1

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Answer
Molecular Genetics   Structure & processes such as replication, transcription, and translation  
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Transmission genetics   Mendelian genetics and its variations  
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How many chromosomes in a human cell?   46  
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How long is DNA in a human cell?   2 meters  
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How many DNA bases in a human cell?   3 billion  
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How many genes that code for proteins in a human cell?   21,000 genes  
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Reverse transcriptase   a type of DNA polymerase that uses an RNA template to synthesize DNA  
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Where is reverse transcriptase commonly found?   retroviruses & retrotransposable elements  
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What are the four levels of biological organization?   Molecular, cellular, organismal, population  
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Small mutations   base substitutions (A to G) or length mutations (insertions or deletions)  
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What's an example of a base substitution?   A to G  
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What's an example of a length mutation?   Insertion or deletion  
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What's PKU?   Phenylketonuria- a disease caused by the inability of an individual to break down amino acid phenylalanine into tyrosine  
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PAH   a gene that codes for the enzyme PAH (phenylalanine hydroxylase) that catalyzes the chemical reaction of breaking down phenylalanine into tyrosine  
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What happens if phenylalanine accumulates?   It's converted into phenylpyruvic acid in the liver which crosses the blood-brain barrier and is toxic to nerve cells; it affects the brain early in development and can cause mental retardation  
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Compound heterozygote   When an individual has two different mutant alleles  
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In terms of PKU, how is it that genotype doesn't necessarily determine phenotype?   Environment can affect whether or not someone has PKU because if it's caught early enough, the diet can be controlled and the brain can develop as it should  
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BH4   Tetrahydrobiopterin- a cofactor of PAH, And the alleles at four genes influence the production & recycling of BH4  
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BBB   Blood-brain barrier- prevents most molecules from entering the brain, and alleles at several genes affect the strength of the BBB  
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