BIO340- Chapter 1
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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Molecular Genetics | Structure & processes such as replication, transcription, and translation
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Transmission genetics | Mendelian genetics and its variations
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How many chromosomes in a human cell? | 46
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How long is DNA in a human cell? | 2 meters
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How many DNA bases in a human cell? | 3 billion
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How many genes that code for proteins in a human cell? | 21,000 genes
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Reverse transcriptase | a type of DNA polymerase that uses an RNA template to synthesize DNA
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Where is reverse transcriptase commonly found? | retroviruses & retrotransposable elements
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What are the four levels of biological organization? | Molecular, cellular, organismal, population
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Small mutations | base substitutions (A to G) or length mutations (insertions or deletions)
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What's an example of a base substitution? | A to G
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What's an example of a length mutation? | Insertion or deletion
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What's PKU? | Phenylketonuria- a disease caused by the inability of an individual to break down amino acid phenylalanine into tyrosine
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PAH | a gene that codes for the enzyme PAH (phenylalanine hydroxylase) that catalyzes the chemical reaction of breaking down phenylalanine into tyrosine
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What happens if phenylalanine accumulates? | It's converted into phenylpyruvic acid in the liver which crosses the blood-brain barrier and is toxic to nerve cells; it affects the brain early in development and can cause mental retardation
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Compound heterozygote | When an individual has two different mutant alleles
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In terms of PKU, how is it that genotype doesn't necessarily determine phenotype? | Environment can affect whether or not someone has PKU because if it's caught early enough, the diet can be controlled and the brain can develop as it should
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BH4 | Tetrahydrobiopterin- a cofactor of PAH, And the alleles at four genes influence the production & recycling of BH4
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BBB | Blood-brain barrier- prevents most molecules from entering the brain, and alleles at several genes affect the strength of the BBB
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