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FA 2010 Key Associations

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
        Help!  

Question
Answer
Actinic (solar) keratosis   Squamous cell carcinoma  
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Acute gastric ulcer associated with CNS injury   Cushing's ulcer (increased ICP stumulates vagal gastric secretions)  
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Acute gastric ulcers associated with severe burns   Curling's ulcers (greatly reduced plasma volume results in sloughing of gastric mucosa)  
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Alternating areas of transmural inflammation and normal colon   Skips lesions (Crohn's disease: autoimmune)  
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Aneurysm, dissecting   Hypertension  
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Aortic aneurysm, abdominal and descending aorta   Atherosclerosis  
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Aortic aneurysm, ascending   Tertiary syphilis  
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Atrophy of mammilary bodies   Wernicke's encephalopathy (thamine deficiency causing ataxia, ophthalmoplegia, and confusion)  
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Autosplenectomy (fibrosis and shrinkage)   Sickle cell anemia (HbS)  
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Bacteremia/pneumonia (IV drug user)   S. aureus  
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Bacteria associated with stomach cancer   H. pylori  
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Bacterial meningitis (adults and elderly)   S. pneumoniae  
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Bacterial meningitis (newborns and kids)   Group B strep (newborns); S. pneumoniae/ N. menigitidis (kids)  
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Benign melanocytic nevus   Spitz nevus (most common in first two decades)  
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Bleeding disorder with GpIb deficiency   Bernard-Soulier disease (defect in platelet adhesion)  
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Brain tumors (adults)   Supratentorial: mets > astrocytoma (including glioblastoma multiforme) > meningioma > schwannoma  
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Brain tumors (kids)   Infratentorial : medulloblastoma (cerebellum) or supratentorial: craniopharyngioma (cerebrum)  
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Breast cancer   Infiltrating ductal carcinoma (in the US, 1/9 women will develop breast cancer)  
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Breast mass   1. Fibrocystic change 2. Carcinoma (in postmenopausal women)  
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Breast tumor (benign)   Fibroadenoma  
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Bug in debilitated, hospitalized pneumonia patient   Klebsiella  
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Cardiac primary tumor (kids)   Rhabdomyoma  
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Cardiac manifestations of lupus   Libman-Sacks endocarditis (nonbacterial, affecting mitral)  
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Cardiac tumor (adults)   1. Metastasis 2. Primary myxoma (4:1 left to right atrium; "ball and valve")  
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Cardiomyopathy   Dilated cardiomyopathy (40% are familial)  
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Cerebellar tonsillar herniation   Arnold-Chiari malformation (often causes hydrocephalus)  
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Chronic arrhythmia   Atrial fibrillation (associated with high risk of emboli)  
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Chronia atrophic gastritis (autoimmune)   Predisposition to gastric carcinoma (can also cause pernicious anemia)  
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Clear cell adenocarcinoma of the vagina   DES exposure in utero  
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Congenital adrenal hyperplasia   21-hydroxylase deficiency  
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Congenital cardiac anomaly   VSD  
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Congenital conjugated hyperbilirubinemia (black liver)   Dubin-Johnson syndrome (inability of hepatocytes to secrete conjugated bilirubin into bile)  
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Constrictive pericarditis in developing world   Tuberculosis  
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Coronary artery involved in thrombus   LAD > RCA > LCA  
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Cretinism   Iodine deficit/ hypothyroidism  
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Cushing's syndrome   1. Corticosteroid therapy 2. Excess ACTH secretion in pituitary  
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Cyanosis (early; less common)   Tetraology of Fallot, transposition of great vessels, truncus arteriosus  
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Cyanosis (late; more common)   VSD, ASD, PDA  
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Death in CML   Blast crisis  
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Death in SLE   Lupus nephropathy  
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Dementia   1. Alzheimer's disease 2. Multiple infarcts  
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Demyelinating disease   Multiple sclerosis  
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DIC   Gram-negative sepsis, obstetric complications, cancer, burn trauma  
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Dietary deficit   Iron  
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Diverticulum in pharynx   Zenker's diverticulum (diagnosed by barium swallow)  
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Ejection click   Aortic/ pulmonary stenosis  
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Esophageal cancer   Adenocarcinoma (US), Squamous cell carcinoma (worldwide)  
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Food poisoning   S. aureus  
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Gene involved in cancer   p53 tumor suppressor gene  
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Glomerulonephritis (adults)   Berger's disease (IgA nephropathy)  
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Gynecologic malignancy   Endometrial carcinoma  
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Heart murmur   Mitral valve prolapse  
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Heart valve in bacterial endocarditis   Mitral (rheumatic fever), tricuspid (IV drug user), aortic (2nd affected in rheumatic fever)  
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Helminth infections (US)   1. Enterobius vermicularis 2. Ascaris lumbricoides  
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Epidural hematoma   Rupture of middle menigeal artery (arterial bleeding is fast)  
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Subdural hematoma   Rupture of bridging veins (trauma; venous bleeding is slow)  
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Hemochromatosis   Multiple blood transfusions (can result in CHF and increased risk of hepatocellular carcinoma)  
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Hepatocellular carcinoma   Cirrhotic liver (often associated with hepatitis B and C)  
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Hereditary bleeding disorder   von Willebrand's disease  
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Hereditary harmless jaundice   Gilbert's syndrome (benign congenital unconjugated hyperbilirubinemia)  
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HLA-B27   Ankylosing spondylitis, Reiter's syndrome, ulcerative colitis, psoriasis  
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HLA-DR3 or -DR4   Diabetes mellitus type 1, rheumatoid arthritis, SLE  
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Holosystolic murmur   VSD, tricuspid regurgitation, mitral regurgitation  
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Hypercoagulability, endothelial damage, blood stasis   Virchow's triad (results in venous thrombosis)  
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Secondary hypertention   Renal disease  
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Hypoparathyroidism   Thyroidectomy  
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Hypopituitarism   Adenoma  
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Infection in blood transfusion   Hepatitis C  
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Kidney stones   1. Calcium = radiopaque 2. Struvite (ammonium) = radiopaque (formed by urease-positive organisms such as Proteus vulgaris or Staphylococcus) 3. Uric acid = radiolucent  
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Late cyanotic shunt (late L->R becomes R->L)   Eisenmenger's syndrome (caused by ASD, VSD, PDA; results in pulmonary hypertension/polycythemia)  
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Liver disease   Alcoholic liver disease  
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Lysosomal storage disease   Gaucher's disease  
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Male cancer   Prostatic carcinoma  
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Malignancy associated with noninfectious fever   Hodgkin's lymphoma  
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Malignant skin tumor   Basal cell carcinoma (rarely metastasizes)  
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Mental retardation   1. Down syndrome 2. Fragile X syndrome  
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Mets to bone   Breast, lung thyroid, testes, prostate, kidney  
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Mets to brain   Lung, breast, skin (melanoma), kidney (renal cell carcinoma), GI  
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Mets to liver   Colon, gastric, pancreatic, breast, and lung carcinomas  
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Mitral valve stenosis   Rheumatic heart disease  
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Motor neuron disease   ALS  
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Myocarditis   Coxsackie B  
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Neoplasm (kids)   1. ALL 2. Cerebellar medulloblastoma  
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Nephrotic syndrome (adults)   Membranous glomerulonephritis  
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Nephrotic syndrome (kids)   Minimal change disease (associated with infections/vaccinations; treat with corticosteroids)  
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Obstruction of male urinary tract   BPH  
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Opening snap   Mitral stenosis  
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Opportunistic infection in AIDS   Pneumocystis jiroveci (formerly carinii) pneumonia  
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Organ receiving mets   Adrenal glands (due to rich blood supply)  
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Organ sending mets   Lung > breast, stomach  
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Osteomyelitis   S. aureus  
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Osteomyelitis in patients with sickle cell disease   Salmonella  
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Osteomyelitis with IV drug use   Pseudomonas  
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Ovarian metastasis from gastric carcinoma or breast cancer   Krukenberg tumor (mucin-secreting signet-ring cells)  
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Ovarian tumor (benign)   Serous cystadenoma  
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Ovarian tumor (malignant)   Serous cystadenocarcinoma  
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Pancreatic tumor   Adenocarcinoma (head of pancreas)  
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Pancreatitis (acute)   EtOH and gallstones  
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Pancreatitis (chronic)   EtOH (adults), cystic fibrosis (kids)  
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Palient with ALL /CLL /AML /CML   ALL: child, CLL: adult > 60, AML: adult > 60, CML: adult 35-50  
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Patient with Hodgkin's disease   Young male (except nodular sclerosis type: female)  
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Pelvic inflammatory disease   Neisseria gonorrhoeae (monoarticular arthritis)  
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Philadelphia chromosome t(9;22) (bcr-abl)   CML (may sometimes be associated with ALL/AML)  
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Pituitary tumor   1. Prolactinoma 2. Somatotropic "acidophilic" adenoma  
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Pneumonia, hospital acquired   Klebsiella  
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Primary amenorrhea   Turner's syndrome (XO)  
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Primary bone tumor (adults)   Multiple myeloma  
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Primary hyperaldosteronism   Adenoma of adrenal cortex  
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Primary hyperparathyroidism   1. Adenomas 2. Hyperplasia 3. Carcinoma  
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Primary liver cancer   Hepatocellular carcinoma (also known as hepatoma)  
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Pulmonary hypertension   COPD  
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Recurrent inflammation/thrombosis of small/medium vessels in extremities   Buerger's disease (strongly associated with tobacco)  
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Renal tumor   Renal cell carcinoma: associated with von Hippel-Lindau and adult polycystic kidney disease; paraneoplastic syndromes (erythropoietin, renin, PTH, ACTH)  
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Right heart failure due to a pulmonary cause   Cor pulmonale  
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S3 (protodiastolic gallop)   ↑ ventricular filling (L → R shunt, mitral regurgitation, LV failure [CHF])  
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S4 (presystolic gallop)   Stiff/hypertrophic ventricle (aortic stenosis, restrictive cardiomyopathy)  
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Secondary hyperparathyroidism   Hypocalcemia of chronic kidney disease  
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Sexually transmitted disease   Chlamydia  
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SIADH   Small cell carcinoma of the lung  
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Site of diverticula   Sigmoid colon  
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Site of metastasis   1. Regional lymph nodes 2. Liver  
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Sites of atherosclerosis   Abdominal aorta > coronary > popliteal > carotid  
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Stomach cancer   Adenocarcinoma  
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Stomach ulcerations and high gastrin levels   Zollinger-Ellison syndrome (gastrinoma of duodenum or pancreas)  
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t(14;18)   Follicular lymphomas (bcl-2 activation)  
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t(8;14)   Burkitt's lymphoma (c-myc activation)  
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t(9;22)   Philadelphia chromosome, CML (bcr-abl hybrid)  
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Temporal arteritis   Risk of ipsilateral blindness due to thrombosis of ophthalmic artery  
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Testicular tumor   Seminoma  
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Thyroid cancer   Papillary carcinoma  
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Tumor in women   Leiomyoma (estrogen dependent)  
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Tumor of infancy   Hemangioma  
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Tumor of the adrenal medulla (adults)   Pheochromocytoma (usually benign)  
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Tumor of the adrenal medulla (kids)   Neuroblastoma (malignant)  
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Type of Hodgkin's   Nodular sclerosis (vs. mixed cellularity, lymphocytic predominance, lymphocytic depletion)  
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Type of non-Hodgkin's   Diffuse large cell  
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UTI   E. oli, Staphylococcus saprophylicus (young women)  
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Viral encephalitis   HSV  
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Vitamin deficiency (U.S.)   Folic acid (pregnant women are at high risk; body stores only 3- to 4-month supply)  
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