p.282-287
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| Vd | Conc in the body/plasma drug concentration
🗑
|
||||
| CL | Rate of Elimination/Plasma drug conc.
🗑
|
||||
| T1/2 | .7 x Vd/CL
🗑
|
||||
| Loading Dose | Conc (target) x Vd/Bioavailabitily
🗑
|
||||
| Maintenance Dose | C (target) x CL/Bioavailability
🗑
|
||||
| Zero order Kinetics | Rate of elimination is constant (linear reduction in drug concentration over time)
🗑
|
||||
| First Order Kinetics | Rate of Elimination is proportional to the drug Conc. (constant Fraction) so that the elimination varies exponentially with time
🗑
|
||||
| what is more predictable first or zero order kinetics | Zero (there is nothing to thing about )
🗑
|
||||
| what is a Phase I metabolism | HOR, Hydrolysis, Oxidation, Reduction (yields slightly polar water soluble often still active metabolite)
🗑
|
||||
| What is a Phast II metabolism | GAS (Glucuronidation, acetylation, and sulfation) yields very polar inactive metabolites
🗑
|
||||
| how long does it take to get to the IND level of drug dev | 4 years (requires dev. of a lead compound and animal testing)
🗑
|
||||
| what are the phases after IND status has been granted | Phase 1(safe?) 2 (does it work?) 3 (Double blind study)
🗑
|
||||
| How long does it take to get to the NDA | New drug application can typically be filed 8-9 years after the intiation
🗑
|
||||
| what is phase 4 of drug development | post marketing surveillance
🗑
|
||||
| what is the order of drug dev. | lead compound, animals, IND, Safe?, Work on patients?, Double blind study?, NDA, Phase 4 surveillance
🗑
|
||||
| what effect does a competitive antagonist have on the curve | it shifts it to the right (can still overcome)
🗑
|
||||
| what effect does a non-competitive antagonist have on the curve | shifts the curve downward, you can't overcome the effect
🗑
|
||||
| what is Kd | refers to the number of receptors involved
🗑
|
||||
| what is Ed | Effective Dose (refers to the effect the drug is having)
🗑
|
||||
| how does a partial agonist compare to a full with respect to potency and efficacy | a partial will always have lower efficacy but may be more or less potent
🗑
|
||||
| Any thing that ends in -cillin Mech | blocks cell wall synthesis by inhibiting cross linking
🗑
|
||||
| Imipenem Mech | blocks cell wall synthesis by inhibiting cross linking
🗑
|
||||
| Aztreonam Mech | blocks cell wall synthesis by inhibiting cross linking
🗑
|
||||
| Cephalosporin | blocks cell wall synthesis by inhibiting cross linking
🗑
|
||||
| Vancomycin mech | blocks peptidoglycan synthesis
🗑
|
||||
| Cycloserine Mech | blocks peptidoglycan synthesis
🗑
|
||||
| bacitracin Mech | blocks peptidoglycan synthesis
🗑
|
||||
| Chloramphenicol mech | 50S block
🗑
|
||||
| allmost all Mycins (not vanco or aminoglycosides) mech | 50S block
🗑
|
||||
| Aminoglycosides (Amikamycin, Gobramycin, Tobramycin) Mech | 30S block
🗑
|
||||
| Sulfonamides and Trimethoprim Mech | Block Nucleotide synthesis
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
FIRST AID
Popular Medical sets