Onc-oncogenes and suppressors
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each of the black spaces below before clicking
on it to display the answer.
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abl | CML, oncogene
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c-myc | burkitt's lymphoma, oncogene
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bcl-2 | follicular and undifferentiated lymphoma (inhibits apoptosis), oncogene
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erb-B2 | breast, ovarian, and gastric carcinoma, oncogene
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ras | colon carcinoma, oncogene
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L-myc | Lung tumor, oncogene
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N-myc | Neuroblastoma
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ret | multiple endocrine neoplasia (MEN) types I and II, oncogene
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Rb | chrom 13q, tumor suppressor, retinoblastoma, osteosarcoma. suppresses G1 -->S by inactivating EF2
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BRCA 1 and 2 | 17q, 13q. tumor suppresor gene, breast and ovarian cancer
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p53 | 17p, tumor suppressor gene, activates apoptosis, most human cancers, Li-Fraumeni syndrome
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p16 | 9p, tumor suppressor gene, melanoma
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APC | 5q, tumor suppressor gene, colorectal cancer
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WT1 | 11q, Wilms' tumor, tumor suppressor gene
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NF1 | 17q, tumor suppressor gene, Neurofibromatosis type 1
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NF2 | 22q, tumor suppressor gene, Neurofibromatosis type 2
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DPC | 18q, tumor suppressor gene, pancreatic cancer
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DCC | 18q, tumor suppressor gene, colon cancer
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PSA (prostatic acid phosphatase) | prostate specific antigen, prostatic carcinoma, used for screening
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CEA | carcinoembyronic antigen. very nonspecific but make by about 70% of colorectal and pancreatic cancers; also produced by gastric and breast carcinomas
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a-fetoprotein | fetus (normal). hepatocellular carcinomas. nenseminomatous germ cell tumors of the testis (eg yolk sac tumor)
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B-hCG | Hyaditidorm mole, choriocarcinoma, gestational trophoblastic tumors
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CA-125 | ovarian, malignant epithelial tumors
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S-100 | melanoma, neural tumors, astrocytoma
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alkaline phosphatase | metastases to bone, obstructive biliary disease, Paget's disease of bone
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bombesin | neuroblastoma, lung and gastric cancer
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TRAP | Tartrate-resistant acid phosphatase. hair cell leukemia, a B cell neoplasm
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t(9;22) | Philadelphia chromosome, CML (bcr-abl hybrid)
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t(8;14) | Burkitt's lymphoma, c-myc activation
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t(14;18) | follicular lymphoma (bcl-2 activation)
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t(15;17) | M3 type of AML (responsive to all trans retinoic acid). translocation of retinoic acid receptor
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t(11;22) | Ewing's sarcoma
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t(11;14) | Mantle cell lymphoma. overexpression of cyclins rushes cell through cycle and results in hyperproliferation.
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Hodgkin's therapy ABVD | adriamycin (doxorubicin), bleomycin, vincristine, dexamethasone
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Hodgkin's therapy MOPP | mustard, oncovin (vincristine), procarbazine, prednisone
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T cell marker | CD 1-8
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B cell marker | CD 10, 19-23
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Mono, mac marker | CD 13, 14, 15, 33
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Stem cell | CD 34
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ALL marker | CD 45
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NK marker | CD 16, 56
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B Cell ALL marker | CD 10, 19, 20
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T Cell ALL Marker | CD1 and Pan T
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CLL marker | CD 5, 23
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