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Onc-oncogenes and suppressors

abl CML, oncogene
c-myc burkitt's lymphoma, oncogene
bcl-2 follicular and undifferentiated lymphoma (inhibits apoptosis), oncogene
erb-B2 breast, ovarian, and gastric carcinoma, oncogene
ras colon carcinoma, oncogene
L-myc Lung tumor, oncogene
N-myc Neuroblastoma
ret multiple endocrine neoplasia (MEN) types I and II, oncogene
Rb chrom 13q, tumor suppressor, retinoblastoma, osteosarcoma. suppresses G1 -->S by inactivating EF2
BRCA 1 and 2 17q, 13q. tumor suppresor gene, breast and ovarian cancer
p53 17p, tumor suppressor gene, activates apoptosis, most human cancers, Li-Fraumeni syndrome
p16 9p, tumor suppressor gene, melanoma
APC 5q, tumor suppressor gene, colorectal cancer
WT1 11q, Wilms' tumor, tumor suppressor gene
NF1 17q, tumor suppressor gene, Neurofibromatosis type 1
NF2 22q, tumor suppressor gene, Neurofibromatosis type 2
DPC 18q, tumor suppressor gene, pancreatic cancer
DCC 18q, tumor suppressor gene, colon cancer
PSA (prostatic acid phosphatase) prostate specific antigen, prostatic carcinoma, used for screening
CEA carcinoembyronic antigen. very nonspecific but make by about 70% of colorectal and pancreatic cancers; also produced by gastric and breast carcinomas
a-fetoprotein fetus (normal). hepatocellular carcinomas. nenseminomatous germ cell tumors of the testis (eg yolk sac tumor)
B-hCG Hyaditidorm mole, choriocarcinoma, gestational trophoblastic tumors
CA-125 ovarian, malignant epithelial tumors
S-100 melanoma, neural tumors, astrocytoma
alkaline phosphatase metastases to bone, obstructive biliary disease, Paget's disease of bone
bombesin neuroblastoma, lung and gastric cancer
TRAP Tartrate-resistant acid phosphatase. hair cell leukemia, a B cell neoplasm
t(9;22) Philadelphia chromosome, CML (bcr-abl hybrid)
t(8;14) Burkitt's lymphoma, c-myc activation
t(14;18) follicular lymphoma (bcl-2 activation)
t(15;17) M3 type of AML (responsive to all trans retinoic acid). translocation of retinoic acid receptor
t(11;22) Ewing's sarcoma
t(11;14) Mantle cell lymphoma. overexpression of cyclins rushes cell through cycle and results in hyperproliferation.
Hodgkin's therapy ABVD adriamycin (doxorubicin), bleomycin, vincristine, dexamethasone
Hodgkin's therapy MOPP mustard, oncovin (vincristine), procarbazine, prednisone
T cell marker CD 1-8
B cell marker CD 10, 19-23
Mono, mac marker CD 13, 14, 15, 33
Stem cell CD 34
ALL marker CD 45
NK marker CD 16, 56
B Cell ALL marker CD 10, 19, 20
T Cell ALL Marker CD1 and Pan T
CLL marker CD 5, 23
Created by: rocktheboat4