A&P2-Class Notes P37-38 Immune #6/Test3

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The compliment system is a group of:

about 20 plasma proteins

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compliment proteins are produced in the

liver

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the compliment proteins enhance:

the action of antibodies

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compliment proteins circulate in an:

inactive state in blood

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compliment proteins can act as:

enzymes or as binding proteins

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The compliment system helps promote:

inflammation AND the process of phagocytosis

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The compliment system attracts:

phagocytes

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A major mechanism to destroy foreign substances in blood?

the compliment system

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the compliment sys also helps release chemical:

activators that amplify inflammatory process

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The action of compliment sys enhances cellular lysis:

of microbial cells & defenses (specific& non-specific)

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Two most significant activation pathways are:

CLASSICAL & ALTERNATIVE PATHWAYS

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One other significant pathway is the:

LECTIN PATHWAY

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The Classical Pathway is mediated by 11 compliment:

Proteins - C-1 to C-9 (C3 splits into a & b)

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The most rapid and effective of the 3 activation pathways in the complement system is:

Classical pathway

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The Classical Pathway starts when:

antibodies bind to invading organism's cell wall surface

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In the Classical pathway, C1 binds to the:

antibody molecule

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The bound C1 molecule acts as an enzyme that:

Catalyzes the COMPLIMENT FIXATION process.

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The classical pathway ends with the conversion of C3:

C3 splits into a & b; Ca causes imflammation; Cb is Opsonization

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C3b binds to target cell's surface & initiates:

final steps of compliment fixation:MAC formation

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MAC STANDS FOR:

MEMBRANE ATTACK COMPLEX

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MAC - a series of complement proteins that can insert:

Into the target cell's membrane & create a hole that ensures lysis of the target cell

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Other C3b proteins will bind to the :

target cells surface (opsonization) creating attachment points for phagocytes

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C3a and other complement proteins focus on:

amplification of the inflammatory response

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C3a's also stimulate:

basophils & mast cells to release histamine & attract neutrophils to area,

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The ALTERNATIVE Pathway is slower AND:

not as effective as the classical pathway

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Alternative pathway occurs when:

antibody molecules are not available

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The alternative pathway is important in defense against:

bacteria, parasites & some virus-infected cells

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Plasma protein factors B, D and P (properdin) interact:

with the antigen

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Interaction of B, D & P with the antigen triggers

C3 conversion

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The alternative pathway-usually occurs at the same time as:

classical pathway

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The alternative was named due to it being:

discovered after the classical pathway was described

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The ALTERNATIVE Pathway AKA

PROPERDIN Pathway

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Compliment fixation refers to binding of C-1 to:

The micro-organism-antibody complexes

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