The compliment system helps promote:

inflammation AND the process of phagocytosis

the compliment sys also helps release chemical:

activators that amplify inflammatory process

The action of compliment sys enhances cellular lysis:

of microbial cells & defenses (specific& non-specific)

Two most significant activation pathways are:

CLASSICAL & ALTERNATIVE PATHWAYS

The Classical Pathway is mediated by 11 compliment:

Proteins - C-1 to C-9 (C3 splits into a & b)

The Classical Pathway starts when:

antibodies bind to invading organism's cell wall surface

The bound C1 molecule acts as an enzyme that:

Catalyzes the COMPLIMENT FIXATION process.

The classical pathway ends with the conversion of C3:

C3 splits into a & b; Ca causes imflammation; Cb is Opsonization

C3b binds to target cell's surface & initiates:

final steps of compliment fixation:MAC formation

MAC - a series of complement proteins that can insert:

Into the target cell's membrane & create a hole that ensures lysis of the target cell

Other C3b proteins will bind to the :

target cells surface (opsonization) creating attachment points for phagocytes

C3a and other complement proteins focus on:

amplification of the inflammatory response

C3a's also stimulate:

basophils & mast cells to release histamine & attract neutrophils to area,

The ALTERNATIVE Pathway is slower AND:

not as effective as the classical pathway

Alternative pathway occurs when:

antibody molecules are not available

The alternative pathway is important in defense against:

bacteria, parasites & some virus-infected cells

The alternative was named due to it being:

discovered after the classical pathway was described

Compliment fixation refers to binding of C-1 to:

The micro-organism-antibody complexes

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Stack #36716

A&P2-Class Notes P37-38 Immune #6/Test3

Question	Answer
The compliment system is a group of:	about 20 plasma proteins
compliment proteins are produced in the	liver
the compliment proteins enhance:	the action of antibodies
compliment proteins circulate in an:	inactive state in blood
compliment proteins can act as:	enzymes or as binding proteins
The compliment system helps promote:	inflammation AND the process of phagocytosis
The compliment system attracts:	phagocytes
A major mechanism to destroy foreign substances in blood?	the compliment system
the compliment sys also helps release chemical:	activators that amplify inflammatory process
The action of compliment sys enhances cellular lysis:	of microbial cells & defenses (specific& non-specific)
Two most significant activation pathways are:	CLASSICAL & ALTERNATIVE PATHWAYS
One other significant pathway is the:	LECTIN PATHWAY
The Classical Pathway is mediated by 11 compliment:	Proteins - C-1 to C-9 (C3 splits into a & b)
The most rapid and effective of the 3 activation pathways in the complement system is:	Classical pathway
The Classical Pathway starts when:	antibodies bind to invading organism's cell wall surface
In the Classical pathway, C1 binds to the:	antibody molecule
The bound C1 molecule acts as an enzyme that:	Catalyzes the COMPLIMENT FIXATION process.
The classical pathway ends with the conversion of C3:	C3 splits into a & b; Ca causes imflammation; Cb is Opsonization
C3b binds to target cell's surface & initiates:	final steps of compliment fixation:MAC formation
MAC STANDS FOR:	MEMBRANE ATTACK COMPLEX
MAC - a series of complement proteins that can insert:	Into the target cell's membrane & create a hole that ensures lysis of the target cell
Other C3b proteins will bind to the :	target cells surface (opsonization) creating attachment points for phagocytes
C3a and other complement proteins focus on:	amplification of the inflammatory response
C3a's also stimulate:	basophils & mast cells to release histamine & attract neutrophils to area,
The ALTERNATIVE Pathway is slower AND:	not as effective as the classical pathway
Alternative pathway occurs when:	antibody molecules are not available
The alternative pathway is important in defense against:	bacteria, parasites & some virus-infected cells
Plasma protein factors B, D and P (properdin) interact:	with the antigen
Interaction of B, D & P with the antigen triggers	C3 conversion
The alternative pathway-usually occurs at the same time as:	classical pathway
The alternative was named due to it being:	discovered after the classical pathway was described
The ALTERNATIVE Pathway AKA	PROPERDIN Pathway
Compliment fixation refers to binding of C-1 to:	The micro-organism-antibody complexes

Created by: Jean and Study Pals

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