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fun path final

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
Neoplasms can be formed due to A. proliferation f*ck ups (ei. check point mistakes) B. Apoptosis f*ck ups C. Both D. None   Both  
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What is a tumor   solid neoplasm  
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Tumor that remains localized   benign  
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Tumors that spread to distant sites   Malignant  
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T or F: Cancer is the cause of one error in the cellular replication process   False! loads of errors  
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What is a karkinos   Termed coined by hippocrates meaning carsinoma  
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The worlds oldest documented of cancer   Egypt, 1500 BC, breast cancer  
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How where tumors treated back then?   cauterization from a fire drill!  
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The incidence of neoplastic disease ____ with age   increases  
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Why was cancer not a major cause of death back in the day?   Humans did not live long enough to develop cancer  
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Are we living in an "epidemic" of cancer?   Nope! cigarettes and such don't cause cancer, silly  
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Are neoplasms reversible? What type of growth?   1. No 2. Autonomus  
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Name 2 cells that do not give rise to tumors   Myocytes and mature neurons  
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Tumors express varying degrees of ____   Differentiation  
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T or F: The stimulus responsible for uncontrolled proliferation may not be identifiable and it is not known for most neoplams   true  
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T or F: The terms benign and malignant refer to the morphological characteristics of a tumor   False! it refers to the overall biological behavior  
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____ tumors kill while ___ usually spare the host   1. Malignant 2. Benign  
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When can a benign tumor be deadly?   When it is in a location that can interfere with vital function (brain, wrapped around aorta, etc)  
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So malignant tumor means death, right?   No, some are so indolent that they can be surgically removed (breast cancer at CT cancer)  
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A benign tumor will be ____ while a malignant tumor can be either ____ or ____   1. Highly differentiated 2. Highly differentiated or highly undifferentiated (aka anaplastic)  
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T or F: benign tumors show a high level of variability in cell differentiation   false, malignant tumors do  
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Example of a tumor that is histologically malignant but usually doesn't metastasize   Basal cell carsinoma  
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Neoplasia   New growth  
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Oncology   Study on tumors  
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Benign tumor   Localized, non invasive  
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Malignant tumor   Cancer: affect distant site aand are invasive  
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Example of tumor that is caused by default in apoptosis   Non-Hodgkins lymphoma  
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The more the tumor cell looks like the cell of origin, the ___ agressive it will be   less  
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Benign tumors grow where?   ON tissue, not in it  
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2 characteristics of malignant tumors   1. In the tissue or cell 2. Metastatic  
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Malignant tumors have a ___ center and lots of ___ therefor it can ____   1. necrotic 2. blood vessels 3. hemorrhage  
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Leiomyoma   Benign smooth muscle tumor  
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Leiomyosarcoma   Malignant smooth muscle tumor  
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____ leads to ____ leads to ____ leads to ____. Which step is the only one that is not reversible   Chronic stress leads to hyperplasia leads to dysplasia (metaplasia) leads to neoplasia (only one that is not reversible)  
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What must the tumor do in order to merit the title of neoplasia?   Penetrate the basement membrane  
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Hairy cell leukemia: Benign or malignant?   Malignant  
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Rhabdomysarcoma   Malignant skeletal muscle tumor  
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Rhabdomyoma   Benign skeletal muscle tumor  
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What causes brain tumors?   Glial cells  
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3 glial cells that can cause tumors. Which one cannot?   1. Astrocyte, oligodendrocyte, ependymal cells 2. Microglia  
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#1 cause of brain tumors   Astrocytes  
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Most aggressive and most common astrocytic malignancy   Glioblastoma multiform  
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A glioblastoma multiform is what type of malignancy?   Astrocytic  
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Bengin tumor suffix   -oma  
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Example of a bengin tumor that does not end in -oma   polyp  
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Malignant tummor that is derived from MESENCHYM   sarcoma  
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Malignant tummor that is derived from EPITHELIAL CELLS   Carcinomas  
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Carcinomas that resemble stratified squamous epithelium   Squamous cell carcinoma  
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Carcinoma that resembles glandular tissue   Adenocarcinoma  
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What tumor is Bengin: A. Melanoma B. Lymphoma C. Both D. None   None! somme crap-tacular exceptions  
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2 things to remember about anaplastic cells (anaplasia)   1. Very pleomorphic 2. Lose polarity  
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What is dysplasia   Loss of uniformity and polarity of cells that is non-neoplastic  
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Carcinoma in situ is a form of what?   Dysplasia  
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What is a carcinoma in situ?   Full thickness epithelial dysplasia  
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These are concidered pre-cancerous lesions   Carcinoma in situ  
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The rate of growth of a tumor is INVERSELY dependant on what?   The degree of differentiation  
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What type of tumor tends to be more differentiated/ What can be said about its growth?   1. Bengin 2. Grows slower  
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Main or primary diffrence between malignant and bengin tumors   Bengin tumors do not invade surrounding tissue while malignant ones do  
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In fact, bengin tumors are seperated from local tissue by what?   Fibrous capsul  
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What is metastasis?   Discontinuous secondary implants from primary malignancy  
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