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Urinary Systen

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Question
Answer
kidneys are located   posterior to the peritoneum and in the superior lumbar region  
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major factor regulating sodium ion concentration in extracellular fluid (ECF) is   aldosterone  
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structural and functional units of the urinary system are   nephrons  
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glomerular capsule, proximal convoluted tubule, loop of Henle, distal convoluted tubule   correct pathway of glomerular filtrate through the nephron  
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hilus is not   a layer surrounding the kidney  
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painful urination   dysuria  
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"tube" that carries urine from the urinary bladder to the outside world is   urethra  
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"tube" that carries urine from the kidney to the urinary bladder is   ureter  
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urinary bladder is made up of   3 smooth muscle layers  
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when moderately full the urinary bladder may contain   500ml of urine  
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two sphincters are found in   urethra  
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by the age of 4 yrs old, children should be able to control   voluntary urination through the night  
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this drops by about 50% by the age of 70   glomerular filtration rate  
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the ascending limb of the Loop of Henle ____ sodium chlorida into interstitim   actively transports  
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active transport in ascending limb of the Loop of Henle _____ concentration of interstitium   increases  
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the fluid inside the ascending limb of the Loop of Henle becomes more   diluted  
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highest concentration of NaCl- in the Loop of Henle is found   near bottom of the loop  
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descending limb of the Loop of Henle supplies ____ to ascending limb   sodium chloride  
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the cells in the descending loop are not permeable to solute, therefore   filtrate becomes more concentrated as water diffuses out  
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very dilute urine with a low specific gravity in the urine indicates   diabetes insipidus  
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excessive fluid intake would lead to the formation of   dilute urine with a low specific gravity  
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blood flows into the glomerulus from   afferent arteriole  
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Podocytes are   cells of the inner layer of the glomerular capsule  
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fluid enters the loop from the   proximal convoluted tubule (PCT)  
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bladder wall contains three layers of smooth muscle, collectively known as the   detrusor muscle  
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bladder wall mucosa consists of   transitional epithelium  
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detrusor muscle & transitional epithelium make the bladder uniquely suited for   storage  
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regulation of blood pH, by elimination of excess acids/alkaline substances from body, is accomplished by   renal mechanism  
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what are the structural and functional units of the kidneys involved in forming urine?   nephrons  
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what enzyme produced by the kidneys helps to regulate blood pressure?   renin  
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aldosterone, a hormone produced by the adrenal glands, helps to   regulate the concentration of sodium ions and other ions in the extracellular fluid  
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what is normally present in filtrate forced from glomerular capillaries but doesn't normally appear in the urine?   glucose  
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filtrate that is formed is essentially blood plasma, which lacks a vital component   proteins  
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what enters the renal tubule by both filtration & secretion?   creatine  
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when appear in urine, indicate a problem   blood cells are normally too large to pass through the filtration membrane  
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cystitis   inflammation of urinary bladder  
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pyelitis   inflammation of a kidney  
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polyuria   excretion of a large volume of urine  
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located within ventral cavity, retroperitoneal position, superior lumbar region   kidneys  
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ADH increases the permeability of the nephron walls to facilitate   tubular reabsorption  
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release of aldosterone is triggered by   Low sodium ion levels, high potassium ion levels, & rising levels of angiotensin  
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lies deep in the kidney & consists of many triangular regions with a striped appearance   renal medulla  
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triangular areas in renal medulla   renal pyramids  
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Cortical tissue that extends between the medullary or renal pyramids is termed   renal columns  
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Each kidney is surrounded by a layer of fibrous tissue called   renal capsule  
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one of the small extensions of the renal pelvis into which the renal papillae open   calyx  
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if one dissected a medullary or renal pyramid, what structure would be found?   collecting tubules  
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when blood volume drops for any reason arterial blood pressure   drops  
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when blood volume drops for any reason hypothalamic osmoreceptors react by becoming   more active  
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when hypothalamic osmoreceptors become more active they   send impulses to the posterior pituitary for the release of ADH  
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The proximal portion of the nephron is located in which layer of the kidney?   Renal cortex  
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The cells of the juxtaglomerular apparatus   secrete renin  
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catalyzes a series of reactions resulting in angiotensin II, causing vasoconstriction   when juxtaglomerular apparatus secretes renin  
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expansion of the ureter into the substance of the kidney forms   renal pelvis  
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flat funnel-shaped tube, which is continuous with the ureter as it leaves the kidney   the renal pelvis  
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filtrate materials found in the nephron first leave the blood at   the glomerulus  
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notch on the medial surface of the kidney, through which the blood vessels enter and leave the kidney, is called   the renal hilus  
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portion of the nephron that is most closely associated with the collecting duct is called   the distal convoluted tubule  
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enlarged, cup-shaped, closed end of renal tubule, which completely surrounds glomerulus   the Bowman's capsule  
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tubular reabsorption   uptake of substances from the lumen of the nephrons  
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three processes, which result in the formation of urine, are   glomerular filtration, tubular reabsorption, & tubular secretion  
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What is the function of renin?   catalyses the formation and release of angiotensin  
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most superficial region of the kidney   the renal cortex  
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where does most reabsorption of substances from the glomerular filtrate occur?   in the proximal convoluted tubule  
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endocrine gland primarily concerned with sodium & potassium ion balance in the body   the adrenal cortex releases aldosterone  
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erythropoietin   hormone secreted by kidneys that stimulates RBC production in bone marrow  
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function of paired ureters   serves as transportation channels to carry urine away from one body region to another  
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function of urinary bladder   provide temporary storage reservoirs for urine  
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kidney   small, dark red organs with kidney-bean shape extend from T12 to L3  
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gives a fresh kidney a glistening appearance   fibrous capsule  
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perirenal fat capsule   surrounds each kidney, acting as cushion against blows  
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renal fascia   outermost capsule, anchoring kidney & holds in place against muscles of trunk wall  
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ptosis   kidneys drop to a low position  
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rapid weight loss can lead to   a condition called ptosis  
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ptosis may cause the ureters of kidneys to   becomed kinked & urine backs up exerting pressure on kidney tissue  
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hydronephrosis   distention of renal pelvis and calices with urine  
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result of obstruction/atrophy of urinary tract   hydronephrosis  
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renal medulla   deep to cortex, darker reddish-brown  
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renal cortex   outer region, light in color  
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apex , tip, points   toward inner region of kidney  
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base faces   toward cortex  
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renal columns separate   renal pyramids with extensions of cortex-like tissue  
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renal pelvis is medial to   hilum; it is a flat, basin-like cavity  
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the renal pelvis is continuous with   ureter, leaving hilum  
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calyces, which collect urine, are   extensions of the renal pelvis; cup-shaped areas enclosing tips of pyramids  
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the blood supply of the kidneys   is rich  
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about 1/4 of total blood supply of body   passes through kidneys each minute  
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renal artery   arterial blood supply of kidney  
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renal artery approaches hilum where it divides into   segmental arteries  
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segmental arteries give off several branches called   interlobar arteries  
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interlobar arteries   travel through renal columns to reach cortex  
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interlobar arteries give off the arcuate arteries at   the cortex-medulla junction  
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arcuate arties   curve over medullary pyramids  
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cortical radiate arteries branch off   arcuate arteries  
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cortical radiate arteries   run outoward to supply cortical tissue  
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venous blood draining from kidney flows through veins that   trace pathway of arterial supply, but in reverse  
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the veins of the kidney emerge from   the kidney hilum  
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there are no segmented   veins  
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glomerulus   knot of capillaries  
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renal tubule   closed end enlarged, cup-shaped & completely surrounds glomerulus  
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Bowman's capsule   visceral layer made up of highly modified, octopus-like cells  
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renal tubule surrounds   the Bowman's capsule  
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podocytes   porous membrane surrounding glomerulus; cells of the Bowman's capsule  
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foot processes of podocytes   long branching processes that intertwine with one another & cling to glomerulus  
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filtration slits   openings in podocytes, between extensions  
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renal tubule extends from glomerular capsule coils & twists, makes a hair-pin loop,   then coils & twists again entering collecting duct  
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as the renal tubule leaves glomerular capsule, coiling & twisting, it is   called the proximal convoluted tubule, or PCT  
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when the renal tubule makes its hair-pin loop, it is   called the loop of Henle  
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when the renal tubule leaves the loop of Henle, coiling & twisting it is   called the distal convoluted tubule, or DCT  
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lumen surface   surface exposed to filtrate  
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lumen surfaces of PCT are covered with   dense microvilli  
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the dense covering of microvilli, in the PCT   increases their surface area  
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most nephrons are called cortical nephrons because   located almost entirely in the cortex  
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situated close to cortex-medulla junction & their loops of Henle dip deep into medulla   juxatmedullary nephrons  
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collecting ducts   receive urine from nephrons & run downward through renal pyramid  
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deliver final urine product into calyces & renal pelvis   the collecting ducts  
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each nephron is associated with 2 capillary beds   glomerulus & peritubular  
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glomerulus capillary bed   specialized for filtration  
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afferent arteriole   arises from cortical radiate artery; "feeder vessel" of the nephron  
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efferent arteriole   receives blood that has passed through glomerulus  
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fed & drained by arterioles, unlike any other in the entire body   the glomerulus capillary bed  
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in the glomerulus capillary bed pressure is much higher because   arterioles are high-resistance vessels & afferent arteriole has larger diameter than efferent  
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the extremely high pressure in the glomerulus capillary bed   forces fluids & solutes out of blood into glomerular capsule  
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peritubular capillary bed   arises from efferent arteriole that drains glomerulus  
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low-pressure, porous vessels adapted for absorption instead of filtration   the peritubular capillary bed  
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peritubular capillary bed cling closely to length of renal tubule, so they can   receive solutes & water from tubule cells as they are reabsorbed from filtrate in tubule  
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peritubular capillary bed drains into   interlobular veins leaving cortex  
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glomerular filtration is a nonselective, passive process where   fluid passes from blood into glomerular capsule portion of renal tubule  
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once fluid in glomerular capsule, called filtrate, which is essentially   blood plasma without blood proteins  
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as long as the systemic blood pressure is normal   filtrate will be formed  
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filtrate production stops if   arterial blood pressure falls too low  
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when arterial blood pressure falls too low filtration stops because   glomerular pressure becomes inadequate to force substances out of blood into tubules  
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oliguria   abnormally low urinary output between 100-400ml/day  
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anuria   abnormally low urinary output less than 100ml/day  
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tubular reabsorption begins as soon as   filtrate enters PCT  
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PCT cells are   "transporters"  
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reabsorption of most substances depends on   active transport processes  
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tubular reabsorption uses membranes carries & are   very selective  
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nitrogenous waste products   urea, uric acid, & creatinine  
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poorly reabsorbed & found in high concentrations in urine   nitrogenous waste products  
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urea   formed by liver as an end product of protein breakdown when amino acids are use for energy  
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uric acid   released when nucleic acids are metabolized  
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creatinine   associated with creatine metabolism in muscle tissue  
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in order to maintain blood pH & electrolyte composition of the blood   various ions are either reabsorbed or allowed to leave in the urine  
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DCT & collecting duct are also active in   the tubular reabsorption process  
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tubular secretion is   tubular reabsorption in reverse  
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tubular secretion also gets rids of substances   not already in filtrate, such as certain drugs, excess K+ or to balance blood pH  
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in 24 hours, 150 to 180 liter of blood plasma is   filtered by glomeruli into tubules  
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in 24 hours, 1.0 to 1.8 liters   of urine is produced  
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freshly voided urine is normally   clear to deep yellow  
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urochrome   pigment resulting from body's destruction of hemoglobin, gives urine yellow color  
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diluted urine is   pale, straw color  
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amonia odor in urine is caused by   action of bacteria on the urine solutes  
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urine pH is usually   slightly acidic 6  
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changes in body metabolism & certain foods may cause urine to be   more basic or acidic  
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diabetes mellitus can alter   the usual odor of urine  
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acid-ash foods   diet of large amount of protein & whole-wheat products causes urine to become more acidic  
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alkaline-ash diet   makes urine alkaline because kidneys excrete excess bases; vegetarian diet  
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bacterial infection of urinary tract can cause   urine to be alkaline  
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urine weighs more, or is more dense than   distilled water  
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specific gravity   compare how much heavier urine is than distilled water  
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sensitve early marker for kidney damage   proteinuria  
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each urter runs behind peritoneum from   renal hilum to posterior aspect of bladder, entering at a slight angle  
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peristalsis of smooth muscles layers of ureters   propel urine into the bladder  
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small valvelike folds of bladder mucosa flap over the urter openings preventing   urine from flowing back into ureters from bladder  
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when urine is extremely concentrated solutes, such as uric acid salts, form   crystals that precipitate in renal pelvis  
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renal calculi   crystals in renal pelvis, or kidney stones  
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lithotripsy   use ultrasound waves to shatter calculi, so they can be painlessly voided in urine  
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urinary bladder is a   smooth, collapsible, muscular sac that temporarily stores urine  
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the urinary bladder is located   retroperitoneally in pelvis, just posterior to pubic symphysis  
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ureteral orifices   two ureter openings  
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internal urethral orifice   single opening of urethra  
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trigone   smooth traingular ergion of bladder base outlined by ureter & internal urethra orifices  
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infections tend to persist in this region   trigone  
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urethra   thin-walled tube that carries urine from bladder to outside of body, via peristalsis  
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bladder-urethra junction a tickening of smooth muscle form   the internal urethral sphincter  
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internal urethral sphincter   involuntary sphincter keeping urethra closed when urine is not being passed  
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external urethral sphincter   skeletal muscle as urethra passes through pelvic floor; voluntarily controlled  
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urethritis   inflammation of urethra  
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micturation/voiding   act of emptying the bladder  
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impulses transmitted to sacral region of spinal cord & back to the bladder   via pelvic splanchnic nerves  
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pelvic splanchnic nerve impulses cause   the bladder to go into reflex contractions, causing the need to void  
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incontinence   unable to voluntarily control external sphincter  
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in children incontinence is usually due to   emotional problems  
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urinary retention is a condition in which   the bladder in unable to expel its contained urine  
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often occurs after surgery or due to hyperplasia of prostate gland   urinary retention  
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hyperplasia   enlargement  
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catheterization is treatment for   the condition of urinary retention  
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blood composition depends on   cellular metabolism, diet & urine output  
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water account for about 75% of body weight in   babies with little fat and low bone mass  
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water account for about 50% of body weight in   women who have more fat than muscle  
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water account for about 60% of body weight in   men who have more muscle than fat  
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water account for about 45% of body weight in   eldery  
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fluid compartments   three main locations with the body occupied by water  
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intracellular fluid (ICF)   fluid compartment contain within living cells  
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extracellular fluid (ECF)   fluid compartment including all body fluids outside the cells  
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2/3 of body fluid is contained in   ICF & ECF  
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ECF includes   blood plasma, intersitial fluid, cerebrospinal fluid, serous fluids, humors of eyes, lymph & others  
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plasma links   internal & external enviroments  
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important to overall body homeostasis   types & amounts of solutes in the body  
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deficit of sodium ions in ECF results in   water loss from bloodstream into tissue spaces & muscular weakness  
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thirst mechanism   driving force for water intake  
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an increase in plasma solute content of 2-3%   excites hypothalamic thirst center  
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reabsorption of water & electrolytes by kidneys is regulated   primarily by hormones  
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osmoreceptors   highly sensitive cells in hypothalamus react to change in blood composition  
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antidiuretic hormone (ADH)   hormone prevents excessive water loss in urine  
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nerve impulses, caused by active osmoreceptors, are sent to   posterior pituitary to release ADH  
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target for ADH is   the kidney's collecting ducts  
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sodium ion is the electrolyte most responible for   osmotic water flows  
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80% of sodium in filtrate is   reabsorbed in PCT of kidneys  
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for each sodium ion reabsorbed   chloride ion follows & potassium ion secreted into filtrate  
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water follows   salt  
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renin-antiotensin mechanism   most important trigger for aldosterone release  
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juxtaglomerular apparatus consists of complex modified smooth muscle cells (JG cells) in   the afferent arteriole  
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juxtaglomerular apparatus consists of modified epithelial cells   forming part of the DCT  
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when JG apparatus stimulated by low blood pressure in afferent arteriole   respond by releasing renin into blood  
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acts directly on adrenal cortical cells to promotes aldosterone release   when juxtaglomerular apparatus secretes renin  
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acidosis   drop in arteial blood pH below 7.35  
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alkalosis   arterial blood pH rises above 7.45  
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physiological acidosis   any arterial blood pH between 7.35 & 7  
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acid-base balance is distrubed by   acidic substances entering the blood, due to H ions originating as by-products of cellular metabloism  
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kidneys assume most of load for maintaining   acid-base balance of the blood  
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chemicals buffers are systems of 1 or 2 molecules that   act to prevent dramatic changes in H+ concentration when acids/bases are added  
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first line of defense in resisting blood pH changes   are chemical buffers  
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weak acids are effective at preventing pH changes since they are   forced to dissociate & release more H+ when pH rises over desirable range  
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important role in chemical buffer system   weak acids  
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weak bases are valuable chemical buffers becasue   when Ph drops, they become "stronger" & tie up more H+  
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three major chemical buffer systems are   bicarbonate, phosphate & protein  
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bicarbonate buffer system   mixture of carbonic acid & sodium bicarbonate  
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strong acid is changed to a weak one, in the bicarbonate buffer system, by   salt acts as base to tie up H+ released by stronger acid forming more carbonic acid  
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cabon dioxide is released expelled from the lungs at the same rate as   it is formed in the tissues  
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lungs can elimanate cardon dioxide but the other acids generated during metabolism   can only be elimanted by the kidneys  
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only the kidneys have the ability to regulate blood levels   of alkaline substance  
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most potent mechanism for regulating blood pH   is the kidneys  
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most important menas the kidneys maintain acid-base balance of blood are   extreting bicarbonate ions & reabsorbing or generating new bicarbonate ions  
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urine pH varies from   4.5 to 8  
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variation in urine pH reflects the ability of   renal tubules to excrete basic/acid ions to maintain blood pH homeostasis  
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the third set of tubule system in an embryo   develops into the functional kidneys  
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embryo is excreting urine by   the third month of fetal life  
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polycystic kidney   degenerative condition where one or both kidenys enlarged with cysts containing urine  
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two most common congenital kidney diseases   polycystic kidney & hypospadias  
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hypospadias   condition found in males only, when urethral orifice located on ventral surface of penis  
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newborn kidneys are not able to concentrate urine for the 1st 2 months because   bladder is very small  
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escherichia coli   normal residents of digestive tract  
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excherichia coli are dangerous pathogens   when they enter urinary system  
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account for about 80% of urinary tract infections   escherichia coli  
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glomerulonephritis   glomerular filters become clogged with antigen-antibody complexes from strep infections  
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