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Autacoids

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Question
Answer
2-methyl histamine   H1 receptor agonist  
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2-pyridylethylamine   H1 receptor agonist  
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2-thiazolyethylamine   H1 receptor agonist  
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4(5)-methyl histamine   H2 receptor agonist  
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Dimaprit   H2 receptor agonist  
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Impromadine   H2 receptor agonist  
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(R)-a-methyl histamine   H3 receptor agonist (weak H4)  
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Clobenpropit   H3 receptor agonist (weak H4)  
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Diphenhydramine (benadryl)   1st gen antihistamine; ethanolamine  
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Dimenhydrinate (dramamine)   1st gen antihistamine; ethanolamine  
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Chlorpheniramine maleate (chlor-trimeton)   1st gen antihistamine; alkylamine  
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Pyrilamine maleate (poly-histine-D)   1st gen antihistamine; ethylenediamine  
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Cyclizine HCL (marezine)   1st gen antihistamine; piperazine  
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Promethazine HCL (phenergan)   1st gen antihistamine; phenothiazine  
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Phenindamine tartrate (nolahist)   1st gen antihistamine; piperidine  
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Acrivastine (semprex-D)   2nd gen antihistamine; alkylamine  
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Cetirizine HCL (zyrtec)   2nd gen antihistamine; piperazine  
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Loratadine (claritin)   2nd gen antihistamine; piperidine  
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Desloratadine (clarinex)   2nd gen antihistamine; piperidine  
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Fexofenadine (allegra)   2nd gen antihistamine; piperidine  
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Terfenadine   2nd gen antihistamine; piperidine; WITHDRAWN from market d/t fatal arrhythmias  
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Cimetidine (tagamet)   H2 receptor antagonist  
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Ranitidine (zantac)   H2 receptor antagonist  
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Famotidine (pepcid)   H2 receptor antagonist  
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Nizatidine (axid)   H2 receptor antagonist  
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H1 Receptor Characteristics   Gq/11 (inc Ca, cAMP); smooth muscle, CNS, endothelial cells; 2-CH3-histamine agonist; chlorpheniramine antagonist  
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H2 Receptor Characteristics   Gs (inc cAMP); gastric parietal cells, cardiac muscles, extravascular smooth muscles; dimaprit agonist; ranitidine antagonist  
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H3 receptor Characteristics   Gi/o (dec cAMP); CNS, presynaptic myenteric plexus; (R)-a-CH2-Hist agonist; Thiperamide & clobenpropit antagonist  
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H4 receptor characteristics   Gi/o (dec cAMP, inc Ca); hematopoeitic cells; Clobenpropit agonist; thioperamide atagonist  
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