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Pharm Block 3

Autacoids

QuestionAnswer
2-methyl histamine H1 receptor agonist
2-pyridylethylamine H1 receptor agonist
2-thiazolyethylamine H1 receptor agonist
4(5)-methyl histamine H2 receptor agonist
Dimaprit H2 receptor agonist
Impromadine H2 receptor agonist
(R)-a-methyl histamine H3 receptor agonist (weak H4)
Clobenpropit H3 receptor agonist (weak H4)
Diphenhydramine (benadryl) 1st gen antihistamine; ethanolamine
Dimenhydrinate (dramamine) 1st gen antihistamine; ethanolamine
Chlorpheniramine maleate (chlor-trimeton) 1st gen antihistamine; alkylamine
Pyrilamine maleate (poly-histine-D) 1st gen antihistamine; ethylenediamine
Cyclizine HCL (marezine) 1st gen antihistamine; piperazine
Promethazine HCL (phenergan) 1st gen antihistamine; phenothiazine
Phenindamine tartrate (nolahist) 1st gen antihistamine; piperidine
Acrivastine (semprex-D) 2nd gen antihistamine; alkylamine
Cetirizine HCL (zyrtec) 2nd gen antihistamine; piperazine
Loratadine (claritin) 2nd gen antihistamine; piperidine
Desloratadine (clarinex) 2nd gen antihistamine; piperidine
Fexofenadine (allegra) 2nd gen antihistamine; piperidine
Terfenadine 2nd gen antihistamine; piperidine; WITHDRAWN from market d/t fatal arrhythmias
Cimetidine (tagamet) H2 receptor antagonist
Ranitidine (zantac) H2 receptor antagonist
Famotidine (pepcid) H2 receptor antagonist
Nizatidine (axid) H2 receptor antagonist
H1 Receptor Characteristics Gq/11 (inc Ca, cAMP); smooth muscle, CNS, endothelial cells; 2-CH3-histamine agonist; chlorpheniramine antagonist
H2 Receptor Characteristics Gs (inc cAMP); gastric parietal cells, cardiac muscles, extravascular smooth muscles; dimaprit agonist; ranitidine antagonist
H3 receptor Characteristics Gi/o (dec cAMP); CNS, presynaptic myenteric plexus; (R)-a-CH2-Hist agonist; Thiperamide & clobenpropit antagonist
H4 receptor characteristics Gi/o (dec cAMP, inc Ca); hematopoeitic cells; Clobenpropit agonist; thioperamide atagonist
Created by: bscaryp
 

 



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