coagulation modifiers
Help!
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| anticoagulants | heparin & warfarin sodium (Coumadin)
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| anticoagulants | given prophylactically
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| anticoagulants | (blank)
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| thrombus | pre-formed clot
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| embolus | clot formed on the wall of a blood vess- that dislodges and travels through system
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| DVT | embolus that had traveled to the veins in the legs
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| warfarin sodium (Coumadin) MOA | works by inhibiting certain clotting factors-- factors that rely heavily onvet. Kfor theri synthesis.
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| heparin MOA | binds to antithrombin III which turns off three main activating factos
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| warfarin sodium (Coumadin) and heparin Indication | MI, unstastable angina, atrial febrillation, indwellng devices( mech heart valves) major orhtopedic surgery
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| warfarin sodium (Coumadin) and heparin Indication | leukemia, pregnancy, GI obstruction, and serious inflammation
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| heparin SE | thrombocytopenia
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| warafin SE | Alopecia, urticaria, dermatitis, nausea
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| Plavix (clopidogrel ) MOA | inhibits platelet aggreagatoin by altering the paltetl membrane so that it can no lnger recieve the signal to aggreage and forma clot. -- better than aspirin at reducing the number of heart attacck, strokes an vasucalt death.
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| Plavix SE | Headache, dizziness, rash
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| Aspirin interaction | given with NSAIDS can potientate bleeding
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| aspirin contraindication | aspirin blocks vitamin K-- can cause stomach and GI bleeding
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| thromboylytics ( streptokinase) | break down pre-formed clots in coronary arteris to prevent a myocardial infarction
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| thromboylytics ( streptokinase) MOA | breaks binds with plaminogen to form an SK plasminogen complex = forms plasmin= lyses the clots.
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| thromboylytics ( streptokinase) SE | internal,intracranial, and superificial bleeding
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| heparin activated partial thromboplastin time (APTT) | 1.5-2 times the control value
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Created by:
mashechka