CV Pharmacology: Test 2
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| First line drug for claudication symptoms in PAD | Cilostazol
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| Second line drug for claudication symptoms in PAD | pentoxifylline
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| MOA for cilostazol | increase cAMP in plateletsm which DECREASE AGGREGATION
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| When in cilostazol contraidicated | heart failure
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| MOA for pentoxifylline | increase in erythrocye flexibility and decrease in fibrinogen (lowers viscosity)
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| Do vasodilators for Raynauds target viens or arteries | ARTERIES!
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| Name four drug classes used in Raynauds | CCB's, ACEI's, A-antagonist, and Vasodilators (nitrates)
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| What is the ultimate cause of pulmonary hypertension | nuerohormonal imbalance
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| `Which hormone is increased and which ones are decreased in pulmonary hypertension | Increase: EndothelinDecrease: NO, protacyclin
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| What is the end result of prolonged pulmonary hypertension | Right sided heart failure
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| Action of endothelin | vasoconstrict, increase cell prolif.
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| In pulmonary hypertension there is an imbalance of Ca+, is there too much or too little, and what does this cause | Too much, causes vasoconstriction/proliferation
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| Does the intima, media, or adeventia of the artery become enlarged? | All of them
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| How many class of pulmonary hypertension? Which is worst | 4, 4
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| What defines Class 4 pulmonary hypertension | inability to carry out physcial activity w/o symptoms
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| What are the three treatment goals of pulmonary hypertension | prevent thromboembolism (anticogulants) and reduce edema (diuretics) and reduce pulmonary resistence
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| Are vasodilators useful in treating pulonary hypertension | no
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| What are the 4 classes of drugs used to treat pulmonary hypertension | CCB's, endothelin antagonist, PGI2, and PDE-5 inhibitors
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| Which three CCB's are used in Pulmonary hypetension | Nifedipine, amlodipine, and ditalizem
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| Which test is used to see if CCB's will work | vasoreactivity test
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| Epoprostenol | prostacyclin agonist/analogue
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| Treprostinil | prostacyclin agonist/analogue
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| Iloprost | prostacyclin agonist/analogue
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| MOA of prostacyclin agonst/analogue | dilates pulmonary arteries, inhibts aggregation, and antiproliferative
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| jaw pain, thrombocytopenia, and luekocytic classic vasculitis are S/E's of what | epoprostenol
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| Which prostacyclin analogue has poor compliance and is taken through inhlaltion | Iloprost
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| Bosentan | Endothlin receptor antagonist
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| Anbrisentan | Andothelin receptor antagonist
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| S/E's of elevated liver aminotransferases and decrease in hemoglobin/hemocrit with teratorgenic effects | Bosentan
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| Sildenafil | PGE-5 inhibitor, causes increase in cGMP and thus vasodilates
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| First line for Class 4 pulmonary hypetension | Epoprostenol
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| Class 2 pulmonary hypertension drug | sildenafil
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| Class 3 pulmonary hypertension drug | bosentan or sildenafil
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