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CV Pharm

CV Pharmacology: Test 2

QuestionAnswer
First line drug for claudication symptoms in PAD Cilostazol
Second line drug for claudication symptoms in PAD pentoxifylline
MOA for cilostazol increase cAMP in plateletsm which DECREASE AGGREGATION
When in cilostazol contraidicated heart failure
MOA for pentoxifylline increase in erythrocye flexibility and decrease in fibrinogen (lowers viscosity)
Do vasodilators for Raynauds target viens or arteries ARTERIES!
Name four drug classes used in Raynauds CCB's, ACEI's, A-antagonist, and Vasodilators (nitrates)
What is the ultimate cause of pulmonary hypertension nuerohormonal imbalance
`Which hormone is increased and which ones are decreased in pulmonary hypertension Increase: EndothelinDecrease: NO, protacyclin
What is the end result of prolonged pulmonary hypertension Right sided heart failure
Action of endothelin vasoconstrict, increase cell prolif.
In pulmonary hypertension there is an imbalance of Ca+, is there too much or too little, and what does this cause Too much, causes vasoconstriction/proliferation
Does the intima, media, or adeventia of the artery become enlarged? All of them
How many class of pulmonary hypertension? Which is worst 4, 4
What defines Class 4 pulmonary hypertension inability to carry out physcial activity w/o symptoms
What are the three treatment goals of pulmonary hypertension prevent thromboembolism (anticogulants) and reduce edema (diuretics) and reduce pulmonary resistence
Are vasodilators useful in treating pulonary hypertension no
What are the 4 classes of drugs used to treat pulmonary hypertension CCB's, endothelin antagonist, PGI2, and PDE-5 inhibitors
Which three CCB's are used in Pulmonary hypetension Nifedipine, amlodipine, and ditalizem
Which test is used to see if CCB's will work vasoreactivity test
Epoprostenol prostacyclin agonist/analogue
Treprostinil prostacyclin agonist/analogue
Iloprost prostacyclin agonist/analogue
MOA of prostacyclin agonst/analogue dilates pulmonary arteries, inhibts aggregation, and antiproliferative
jaw pain, thrombocytopenia, and luekocytic classic vasculitis are S/E's of what epoprostenol
Which prostacyclin analogue has poor compliance and is taken through inhlaltion Iloprost
Bosentan Endothlin receptor antagonist
Anbrisentan Andothelin receptor antagonist
S/E's of elevated liver aminotransferases and decrease in hemoglobin/hemocrit with teratorgenic effects Bosentan
Sildenafil PGE-5 inhibitor, causes increase in cGMP and thus vasodilates
First line for Class 4 pulmonary hypetension Epoprostenol
Class 2 pulmonary hypertension drug sildenafil
Class 3 pulmonary hypertension drug bosentan or sildenafil
Created by: lowryc
 

 



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