Pharmacology test 2 jeopardy questions lilk8tob
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| The most common adverse (allergic) reaction to penicillin | Urticaria (hives), pruritis (itching), angioedema (swollen lips)
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| Gram stain hue of bacteria most commonly destroyed by penicillins | Gram positive
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| Enzyme created by bacteria capable of destroying penicillins. | Betalactamase
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| Key drug- 3rd generation cephalosporin | Cefoxitin, ceftazidime
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| Types of organisms killed by 3rd generation cephalosporins | Best: G- poor: G+
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| Coadministration with these may decrease oral absorption of tetracyclines | milk, antacids, iron salts
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| This reason precludes use of tetracycline in pregnant/lactating women and ped. patients | binds to calcium, stains teeth of neonate or child
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| Sulfonamides are primarily used to treat this kind of infection | UTI (high concentration in kidneys)
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| Common allergic reaction with sulfonamides | Delayed cutaneous reactions
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| Sulfonamides produce varying interaction when taken with this drug class | oral anticoagulants
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| Key drug- macrolide and common side effect | Erythromycin, stomach irritation, GI upset
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| Primary excretion site of quinolones | kidneys
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| Unless contraindicated fluid intake (ml/d) encouraged for someone on quinolones: | 3 L/day
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| Reason quinolones contraindicated in pregnant and ped. patients | shown to affect cartilage development in lab animals
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| 2 drugs or drug classes that interact with quinolones | theophylline and oral anticoagulants
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| key drug- aminoglycocides | Gentamycin, amikacin
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| Two serious toxicities of aminoglycosides | Nephrotoxicity (renal failure) and ototoxicity (hearing loss)
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| Renal function blood tests that will be monitored before and during aminoglycoside therapy | BUN and serum creatinine levels
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| Symptoms of ototoxicity | Tinnitus, dizziness, feeling of fullness in ears, hearing loss
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| Terms for blood levels drawn 1 hr after drug administration and just prior to next dose | peak and trough
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| Two drugs in "other or misc." antibiotic class | Vancomycin, Clindamycin
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| Antibiotic of choice for the treatment of MRSA | Vancomycin
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| Correct rate of IV administration of vancmycin | Over at least 60 minutes
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| Symptoms and treatment of Redman's Syndrome | hypotension, flushing of neck and face; antihistamine will be ordered
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| Two similarities of toxicity between aminoglycocides and vancomycin | nephrotoxicity and ototoxicity
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