test two- drug side effects lilk8tob
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| salicylates - SE | bleeding
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| NSAIDS - SE | GI distress, GI bleeding,
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| NSAID GI problems are lessened with ____ inhibitors | COX-2
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| antiinflammatory- GI effects are commonly associated with : | aspirin
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| Chronic salicylate intoxication symptoms (adults): | tinnitus & hearing loss
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| Chronic salicylate intoxication symptoms (kids) | hyperventilation & CNS effects
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| Acute salicylate overdose | Similar to chronic, but effects are more pronounced & occur more quickly
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| nonsalicylate NSAID overdose: | similar effects, just not as extensive or dangerous
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| Immunosuppressants - SE | heightened susceptibility to opportunistic infections
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| Azathioprine & Cyclosporine SE | blood dyscrasias, hepatotoxicity, neurotoxicity, nephrotoxicity
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| Muromonab-CD3 SE | chest pain, chills, GI symptoms, flulike symptoms, fluid retention
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| Sulfonamides | allergic reactions, leukopenia, nausea, vomiting, renal failure
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| Penicillins | allergic reactions - urticaria (hives), pruritus (itching), angioedema (swollen lips); SE: GI in nature, lethargy, anemia, increased bleeding, rash
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| Cephalosporins | decrease effectiveness of BC pills, cross-sensitivity w/ penicillins
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| Macrolides | GI tract, compete w/ other drugs for hepatic metabolism
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| Tetracyclines | teeth discoloration (not for kids/preg.), photosensitivity, superinfections, alter vaginal floral, retard fetal skeletal development; no dairy
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| Aminoglycosides | ototoxicity, nephrotoxicity *do BUN, creatine and CBC
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| Fluoroquines | not for children (affects cartilage dev., pts on antiarrhythmic agents), headache, diziness, insomnia, nausea, constipation, heartburn, photosensitivity; don't use w/ antacids, iron or zinc
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| Vancomycin (vancocin) | narrow therapeutic range - ototoxicity & nephrotoxicity
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| Isoniazid (INH) | do not drink alcohol while on this!! Hard on liver, take Vitamin B6
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| antifungals | drug interactions & hepatotoxicity are primary concerns - need ALT & AST blood tests
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| antiprotozoal agents | do not take w/ alcohol- causes flushing, nausea & vomiting,
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| helminithic | not for pregnant women
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