PharmT1
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each of the black spaces below before clicking
on it to display the answer.
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Aminoglycosides: Gentamicin, Tobramycin, Streptomicin | cause Ototoxicity
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Metabolism -> | increased elimination
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Glutathione S-transferases | play a role in chemo tx efficacy
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3rd gen Ceftriaxone | least affected by renal insufficiency
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Ceftriaxone | does not tx Gr+ cocci
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Streptogramins | only tx Gr+ and some intracellular bacteria
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Macrolides | prevent translocation
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Isoniazid resistant TB mutates | Catalase
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Sulfonamides | contra-indicated in neonates ob neonatal bilirubin displacement
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Nonlinear | does dependent
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AminoGlycosides | have mult +charges, poor oral absorpt, no CNS penetration
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tylenol toxicity | Glutathione depletion
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Tetracycline | protein synthesis inhibitor, broad Gr+/-, spirochete
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A-biotic antagonists | Penicillin G + Tetracycline
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Cipro AE | cartilage and tendon damage
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CYP450 | catalyze oxidation reaction
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CYP34A | genetic differences not responsible for pt variation
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Aztreonam | Beta lactam with dec cross sensitivity in pt w/ penicillin allergy
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Impinem | sensitive to fewer Beta lactamases than Amoxicillin
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Drug A [part coeff 0.7] v. Drug B [part coeff 4] | Drug A will equilibrate and de-equilibrate faster than Drug B
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MRSA and VRSA | tx w/ Linezolid
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EtOHic + TB | cont tx and adjust dose even in hepatotoxicity
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Ceftriaxone | penetrate CNS and cover S. pneumo
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target of Flutamide | Receptor
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Azithromycin | tx kid with Lyme Dz
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Caspofungin | tx pt w/ AIDS + Fluconazole Resistant fungus
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non compliant TB pt | add ethionamide
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Clindamycin | tx strep resistant to M-lide and Pen
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Terbinafine | tx nail fungus w/ oral absorb
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surg wound infection | Impenim-Cilastin
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cause of RF | purine breakdown product from chemo tx
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MRSA | tx w/ Clindamycin
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MRSA | do not tx w/ Aztreonam, Pipercillin, Cephasporin
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DNA modification | Cyclophosphamide [pro-drug]
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Anastrazole | tx pt w/ active Estrogen R
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Doxorubin | reactive oxygen species
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Kd | [ ] at 1/2 R
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5FU | 1st line for colon CA, inhibit Pyrimidine synthesis, alter RNA
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Carmustine | DNA alkylator tx brain CA,cross-links DNA
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Streptogramin only tx | Gr+
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AminoGlycosides are primarily | Bactericidal
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Low urine pH leads to increased excretion of | bases
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Leads to increased excretion of bases | Low urine pH
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Depolarize Gr+ as MOA | Daptomycin
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Tx Strep multi-resistant | Clindamycin
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Narcotic OD ob | CYP3A4 inhibition
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