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Spinal cord disorders

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Question
Answer
Brown Sequard manifestations   lateral column(corticospinal) ipis spastic paralysis babinksi +; Dorsal column(discim) ipsi loss, anterlateral(spinothalamic) pain and temp contra 2 levels below; at level ispi loss motor(flaccid) sensory, reflex)  
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ALS manifestations   Progressive bulbar palsy(motor of CN): dysarhtria, Progressive muscular atrophy(motor neurons of SC): flaccid paralysis), Primary lateral Sclerosis(corticospinal tract): hypereflexia, spastic paralysis; all three=ALS  
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ALS causes   immune mediate, genetically disposed(10% mutation of SOD), viral  
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Syringomyelia   sensory dissociation(still have discrim and pressure)dec pain and temp at level(commissural fibers destroyed) or below, progressive cavitation toward ant horn flaccid at level, spastic below if cortico is hit  
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Grade I astrocytoma   pilocystic astrocytoma; children; cerebellum and optic nerve, slow growth, good prog, tx: resect 90% survive  
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Grade II astrocytoma   diffuse astrocytoma, 5 year w/ surgery 25% + rad 50% may transform  
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Grade III astrocytoma   Cerebral hemisphere no necrosis, no microvascular life expectancy 2-5 years  
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Grade IV astrocytoma   Glioblastoma Multiform, 50% bilateral, vascular necrotic center, <10% 2 year survival, 80% die within year of Dx,  
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General manifestations of cerebellar   Ataxia, nucal rigidity, papilledem  
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most common in Adults   above tentorium;oligodenroglioma  
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Tumors most common in children   Below tent; Pilocystic astrocytoma,medulloblastoma, retinoblastoma, Hemangioblastoma hipple lindau,  
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Characteristics of mengigiomas   benign 90%, encapsulated, recurrence common, orig from dura or arachnoid, compress underlying, erode bone, seizures  
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sources of mets to brain   25% of all cancer patients get mets to the brain, 1/3 from lung(60% SCLC), 1/6th from breast  
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Childhood brain tumors associated with renal tumors   Hipple lindau; tumors in cerebellum brainstem and spinal cord and retina, cysts on kidneys liver and pancreas mutation of tumor supressor gene p53  
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Characteristics of acoustic neuroma   CN VIII, pontocerebellar junction, common pres: tinnitus, deafness, vertigo, unsteady gait, surg radassociated with MISME and NF  
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Visual field deficits based on location of tumor   temporal pie in the sky, parietal pie on the floor, pituitary bitemporal hemianopsia,  
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hormones which regulate blood glucose   GH ^ bs, ACTH ^ BS,  
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Manifestations of Cushing's   moon facies, bufalo hump, truncal obesity, skinny arms and legs, insulin resistance  
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Locations of ependymomas   4th ventricle  
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Tumors which calcify   oligodenrdomas, meningiomas  
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retinoblastoma   mutations of RB gene bilateral both mom and dad found in all cells of body,  
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