Brown Sequard manifestations

lateral column(corticospinal) ipis spastic paralysis babinksi +; Dorsal column(discim) ipsi loss, anterlateral(spinothalamic) pain and temp contra 2 levels below; at level ispi loss motor(flaccid) sensory, reflex)

Progressive bulbar palsy(motor of CN): dysarhtria, Progressive muscular atrophy(motor neurons of SC): flaccid paralysis), Primary lateral Sclerosis(corticospinal tract): hypereflexia, spastic paralysis; all three=ALS

immune mediate, genetically disposed(10% mutation of SOD), viral

sensory dissociation(still have discrim and pressure)dec pain and temp at level(commissural fibers destroyed) or below, progressive cavitation toward ant horn flaccid at level, spastic below if cortico is hit

pilocystic astrocytoma; children; cerebellum and optic nerve, slow growth, good prog, tx: resect 90% survive

diffuse astrocytoma, 5 year w/ surgery 25% + rad 50% may transform

Grade III astrocytoma

Cerebral hemisphere no necrosis, no microvascular life expectancy 2-5 years

Glioblastoma Multiform, 50% bilateral, vascular necrotic center, <10% 2 year survival, 80% die within year of Dx,

General manifestations of cerebellar

Ataxia, nucal rigidity, papilledem

most common in Adults

above tentorium;oligodenroglioma

Tumors most common in children

Below tent; Pilocystic astrocytoma,medulloblastoma, retinoblastoma, Hemangioblastoma hipple lindau,

Characteristics of mengigiomas

benign 90%, encapsulated, recurrence common, orig from dura or arachnoid, compress underlying, erode bone, seizures

sources of mets to brain

25% of all cancer patients get mets to the brain, 1/3 from lung(60% SCLC), 1/6th from breast

Childhood brain tumors associated with renal tumors

Hipple lindau; tumors in cerebellum brainstem and spinal cord and retina, cysts on kidneys liver and pancreas mutation of tumor supressor gene p53

Characteristics of acoustic neuroma

CN VIII, pontocerebellar junction, common pres: tinnitus, deafness, vertigo, unsteady gait, surg radassociated with MISME and NF

Visual field deficits based on location of tumor

temporal pie in the sky, parietal pie on the floor, pituitary bitemporal hemianopsia,

Manifestations of Cushing's

moon facies, bufalo hump, truncal obesity, skinny arms and legs, insulin resistance

mutations of RB gene bilateral both mom and dad found in all cells of body,

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Neuropath final

Spinal cord disorders

Question	Answer
Brown Sequard manifestations	lateral column(corticospinal) ipis spastic paralysis babinksi +; Dorsal column(discim) ipsi loss, anterlateral(spinothalamic) pain and temp contra 2 levels below; at level ispi loss motor(flaccid) sensory, reflex)
ALS manifestations	Progressive bulbar palsy(motor of CN): dysarhtria, Progressive muscular atrophy(motor neurons of SC): flaccid paralysis), Primary lateral Sclerosis(corticospinal tract): hypereflexia, spastic paralysis; all three=ALS
ALS causes	immune mediate, genetically disposed(10% mutation of SOD), viral
Syringomyelia	sensory dissociation(still have discrim and pressure)dec pain and temp at level(commissural fibers destroyed) or below, progressive cavitation toward ant horn flaccid at level, spastic below if cortico is hit
Grade I astrocytoma	pilocystic astrocytoma; children; cerebellum and optic nerve, slow growth, good prog, tx: resect 90% survive
Grade II astrocytoma	diffuse astrocytoma, 5 year w/ surgery 25% + rad 50% may transform
Grade III astrocytoma	Cerebral hemisphere no necrosis, no microvascular life expectancy 2-5 years
Grade IV astrocytoma	Glioblastoma Multiform, 50% bilateral, vascular necrotic center, <10% 2 year survival, 80% die within year of Dx,
General manifestations of cerebellar	Ataxia, nucal rigidity, papilledem
most common in Adults	above tentorium;oligodenroglioma
Tumors most common in children	Below tent; Pilocystic astrocytoma,medulloblastoma, retinoblastoma, Hemangioblastoma hipple lindau,
Characteristics of mengigiomas	benign 90%, encapsulated, recurrence common, orig from dura or arachnoid, compress underlying, erode bone, seizures
sources of mets to brain	25% of all cancer patients get mets to the brain, 1/3 from lung(60% SCLC), 1/6th from breast
Childhood brain tumors associated with renal tumors	Hipple lindau; tumors in cerebellum brainstem and spinal cord and retina, cysts on kidneys liver and pancreas mutation of tumor supressor gene p53
Characteristics of acoustic neuroma	CN VIII, pontocerebellar junction, common pres: tinnitus, deafness, vertigo, unsteady gait, surg radassociated with MISME and NF
Visual field deficits based on location of tumor	temporal pie in the sky, parietal pie on the floor, pituitary bitemporal hemianopsia,
hormones which regulate blood glucose	GH ^ bs, ACTH ^ BS,
Manifestations of Cushing's	moon facies, bufalo hump, truncal obesity, skinny arms and legs, insulin resistance
Locations of ependymomas	4th ventricle
Tumors which calcify	oligodenrdomas, meningiomas
retinoblastoma	mutations of RB gene bilateral both mom and dad found in all cells of body,

Created by: bmg4

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