Duke PA Synovial Fluid Analysis
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| general marker of inflammation | ESR
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| most commonly assessed acute phase reactants as markers of inflammation | ESR, CRP
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| sed rate | ESR
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| use a __ top tube for sed rate | lavender
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| rate at which RBC's fall to bottom of anticoagulated column in a specific time period | ESR
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| ESR is | not sensitive or specific
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| ESR for males __mm/hr | 15
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| ESR for females__mm/hr | 20
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| use a __ top tube for CRP | red
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| Correlates well with tissue necrosis or inflammation; positive test indicates the presence, but not cause of the disease; may help predict coronary disease | CRP
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| Positive in 60-80% of RA patients, but not specific (also present in health, other autoimmune dz, & chronic infections | Rheumatoid Factor (RF)
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| Positive in 70% of RA patients, only 2% of random blood donors; more specific test than RF for dx RA | Anti-cyclic citrullinated peptide (anti-CCP)
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| Screening test for connective tissue disorders (pos in SLE, Sjögren’s syndrome, MCTD); titer & confirmatory tests of specific autoantibodies are done if ANA screen positive. | Antinuclear antibody (ANA)
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| Useful for diagnosis & follow-up of SLE | Anti-DNA antibody
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| typically seen in Wegener’s granulomatosis | C-ANCA
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| seen in many forms of vasculitis | P-ANCA
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| Diagnostic for sclerodermaPos in 45% of patients with scleroderma | antiscleroderma antibody
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| Most commonly performed on knee, but can be done on any involved joint, Used to evaluate monoarticular effusions or when joint disorder etiology unknown, Requires sterile technique to prevent osteomyelitis | arthrocentesis
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| arthrocentesis is most commonly done on the __ joint | knee
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| culture should include cultures for | Neisseria, Streptococcus, and Staphylococcus
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| normal synovial fluid appears | clear and straw-colored
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| glucose of normal synovial fluid should be within __mg/dL of plasma glucose concentration | 10
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| normal WBC <__ cells/microL | 200
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| normal RBC <__ cells/microL | 2000
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