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DU PA Syn Flu Analy

Duke PA Synovial Fluid Analysis

general marker of inflammation ESR
most commonly assessed acute phase reactants as markers of inflammation ESR, CRP
sed rate ESR
use a __ top tube for sed rate lavender
rate at which RBC's fall to bottom of anticoagulated column in a specific time period ESR
ESR is not sensitive or specific
ESR for males __mm/hr 15
ESR for females__mm/hr 20
use a __ top tube for CRP red
Correlates well with tissue necrosis or inflammation; positive test indicates the presence, but not cause of the disease; may help predict coronary disease CRP
Positive in 60-80% of RA patients, but not specific (also present in health, other autoimmune dz, & chronic infections Rheumatoid Factor (RF)
Positive in 70% of RA patients, only 2% of random blood donors; more specific test than RF for dx RA Anti-cyclic citrullinated peptide (anti-CCP)
Screening test for connective tissue disorders (pos in SLE, Sjögren’s syndrome, MCTD); titer & confirmatory tests of specific autoantibodies are done if ANA screen positive. Antinuclear antibody (ANA)
Useful for diagnosis & follow-up of SLE Anti-DNA antibody
typically seen in Wegener’s granulomatosis C-ANCA
seen in many forms of vasculitis P-ANCA
Diagnostic for sclerodermaPos in 45% of patients with scleroderma antiscleroderma antibody
Most commonly performed on knee, but can be done on any involved joint, Used to evaluate monoarticular effusions or when joint disorder etiology unknown, Requires sterile technique to prevent osteomyelitis arthrocentesis
arthrocentesis is most commonly done on the __ joint knee
culture should include cultures for Neisseria, Streptococcus, and Staphylococcus
normal synovial fluid appears clear and straw-colored
glucose of normal synovial fluid should be within __mg/dL of plasma glucose concentration 10
normal WBC <__ cells/microL 200
normal RBC <__ cells/microL 2000
Created by: bwyche