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Microbe-Human Interactions

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Term
Definition
Symbiosis   living together have these relationships with countless microorganisms  
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Types of symbiosis   Mutualism commensalism parasitism  
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Mutualism   both benefits  
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Commensalism   benefits one and neither benefits nor harms the other  
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Parasitism   benefits one and the other is harmed  
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Normal (resident) flora/indigenous flora   microbes that engage in mutual or commensal associations ration of cells: 10:1  
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Infection   a condition in which pathogenic microbes penetrate host defenses, enter tissues, and multiply  
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Infectious disease   an infection that causes damage or disruption to tissues and organs  
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Normal flora/indigenous microbiota   organisms that colonize the body's surfaces without normally causing disease  
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Normal flora is...   essential to the health of humans  
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Flora create...   an environment that may prevent infections and can enhance host defenses  
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What may alter flora?   antibiotics, dietary changes, and disease  
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Probiotics   introducing known microbes back into the body  
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Opportunistic pathogens   normal flora that cause disease under certain circumstances  
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Conditions that provide opportunities for opportunistic pathogens?   -introduction of normal flora into unusual site in body -immune suppression -changes in the normal flora ----changes in relative abundance may allow opportunity for a member to thrive and cause disease  
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Reservoirs of infection   sites where pathogens are maintained as a source of infection  
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3 types of reservoirs   Animal reservoirs Human carriers Nonliving reservior  
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Zoonoses   diseases naturally spread from animal host to humans (MAJORITY OF HUMAN INFECTIONS)  
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Acquire zoonoses through various routes...   -direct contact with animal or its waste -eating animals -vectors  
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Vector   a live animal that transmits an infectious agent from one host to another  
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Majority of vectors are?   anthropods: fleas, mosquitos, flies, and ticks  
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Biological vectors   actively participate in a pathogen's LIFE CYCLE  
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Mechanical vectors   not necessary to the life cycle of an infectious agent and MERELY TRANSPORTS it without being infected  
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Human carriers   infected individuals who are asymptomatic but infective to others -some individuals eventually develop illness while others never get sick  
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Nonliving reserviors   soil, water, fomites, and food can be reservoirs of infection  
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Fomites   inademiate object -cell phone  
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Pathogenicity   ability of a microorganism to cause disease  
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Virulence   -look @ structure & chemistry help to be pathogenic -factors contribute to pathogenicity: Adhesion factors biolfims extracellular enzymes toxins antiphagocytic factors  
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Infectious dose   -minimum number of microbes required for infection to proceed -microbes with smaller IDs have greater virulence  
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Infectious diseases five stages   -incubation period -prodromal period -illness -decline -convalence  
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Incubation period   no sign/symptom-pathogen colonized  
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Prodromal period   feel under the weather, not typical sign  
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illness   really feel it, signs/symptoms  
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decline   get better  
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Localized Infection   microbes enter the body and remains confined to a specific tissue  
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Systematic infection   infection spreads to several sites and tissue fluids usually in the bloodstream  
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Focal infection   when infectious agent breaks loose from a local infection and is carried to other tissues  
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Mixed infection   several microbes grow simultaneously at the infection site-POLYMICROBIAL  
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Primary infection   initial infection  
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Secondary infection   another infection by a different microbe  
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Acute infection   comes on rapidly, with sever but short-lived effects  
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Chronic infections   progress and persist over a long period of time  
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epidemiology   the study of where and when diseases occur, and how they are transmitted  
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Mortality rate   total number of deaths in a population due to a certain disease  
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Morbidity rate   number of people afflicted with a certain disease  
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Prevalence   number of total cases of a disease in a given area during a given period of time  
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Sporadic   when occasional cases are reported at irregular intervals  
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Endemic   disease that exhibits a relatively steady frequency over a long period of time in a particular geographic locale  
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Epidemic   when prevalence of a disease is increasing beyond what is expected  
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Pandemic   epidemic across countries and continents  
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