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Clinical exam 4

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Question
Answer
Complete recovery of swallowing reflex takes ____ after return of consciousness after propofol anesthesia   15 min  
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15 mg of valium depresses the swallowing reflex up to _____   4 hrs  
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Versed depresses swallowing reflex up to ____ after return to normal state of consciousness   2 hrs  
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In healthy adult males, administration of ____% nitrous oxide as a sedative caused marked depression of swallowing reflex   50%  
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Opioids & benzos together have marked _____ reponse to the respiratory responsiveness   synergistic  
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Besides hypoxia, airway obstruction, & death, other possible disadvantages include (there are 6):   lack of control over the airway, technique failure, pt dissatisfaction, surgeon dissatisfaction, excitement, prolonged recovery  
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In a normal awake subject, upper airway collapse is prevented by __________ that holds open the pharynx, larynx, & trachea   upper airway dilator muscle tone  
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Upper airway dilator muscle tone is exquisitely sensitive to ______ drugs   sedative-hypnotic drugs  
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When airway tone decreases, the diameter of the airway is _____ & airway resistance is markedly _______. Which law is this?   diameter is reduced, resistance is increased. Poiseuille's Law  
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In the alveolar gas equation, if PACO2 increases from 40 to 80 d/t hypoventilation, PAO2 will decrease from 100 to _____   50  
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What is the alveolar gas equation?   PAO2 = FiO2(Pb - Ph20)-(PaCO2/R)  
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What is the normal partial pressure of water (Ph20)?   47 mmHg  
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What are the 5 causes of hypoxemia?   Low FiO2, hypoventilation, V/Q mismatch, diffusion abnormalities, pulmonary right-to-left shunt  
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What are the 2 causes of hypercarbia?   hypoventilation & V/Q mismatch  
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What is the mechanism of action of benzos?   benzos enhance the chloride gating function of GABA by fascilitating the binding of this inhibitory neurotransmitter to its receptor  
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GABA receptors are found throughout ____, with concentrations in ________   CNS, cerebral cortex  
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Actions of GABA on CNS include (4 things):   alterations in sleep, anxiety, memory & (in larger doses) hypnosis  
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Enhancement of GABA causes ________   disinhibitory behavior (pt may become less cooperative)  
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Which ion channel function is enhanced by benzos?   Chloride channel (benzos enhance Cl- gating fxn of GABA by facilitating the binding of this inhibitory NT to its receptor)  
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Sedation is defined as.....   a pharmacologically induced depression of consciousness consisting of varying degrees of amnesia, anxiolysis & analgesia tailored to the pt's needs for the procedure. Continuum is from minimal (light) sedation through deep sedation/GA  
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Minimal sedation is defined as.....   a drug-induced state during which pts respond normally to verbal commands. Although cognitive fxn & physical coordination may be impaired, airway reflexes, & ventilatory & CV fxns are usually unaffected  
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Moderate sedation is also called _______ _______   conscious sedation  
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Moderate sedation is defined as.....   a drug-induced depression of consciousness; pts respond purposefully to verbal commands, either alone or accompanied by light tactile stimulation. No interventions are req'd to maintain a patent airway, & spont vent is usually adequate. CV fxn maintained  
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Reflex withdrawal from a painful stimulus (is / is not) considered a purposeful response   is not  
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Deep sedation/analgesia is defined as.....   a drug-induced depression of consciousness; pts cannot be easily aroused, but respond purposefully following repeated or painful stimulation. Spont vent may be inadequate. May have impaired ability to maintain airway. CV fxn usually maintained  
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General anesthesia is defined as ...   drug-induced LOC. Pts are not arousble, even to painful stimulation. Ability to maintain vent fxn is often impaired. Often req assistance to maintain patent airway & may need positive pressure ventilation. CV fxn may be impaired  
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5 Goals of sedation from American Academy of Pediatrics are:   - to guard pt's safety & welfare. - minimize discomfort & pain. - minimize negative psychological responses to treatment by providing analgesia, & maximize amnesia potential - control behavior - return pt to state of safe discharge  
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