BLOCK 2
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| Easily disseminated/transmitted person->person, high mortality -> public health impact, panic/social disruption, requires action for preparation | Category A (High priority)
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| Moderate dissemination, Moderate/Low mortality, Requires increase in CDC diagnostic capacity, Considered Biological Weapons | Category B (Second priority)
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| Easily available,easily produced/disseminated, potential high motality/morbidity/IMPACT, Preparedness requires ongoing research into detection,diagnosis, treatment, prevention | Category C (emerging organisms)
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| Anthrax | A (inhalation)
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| Botulism | A (inhalation)
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| Plague | A
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| Smallpox | A
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| Tularemia | A
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| Viral hemorrhagic fevers (Ebola, Marburg) | A
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| Brucellosis (Brucella) | B
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| Food safety threats (E. coli O157:H7) | B
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| Q fever (Coxiella burnetii) | B
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| Ricin toxin (Ricinus communis - castor beans) | B (percutaneous)
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| Influenza | C
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| SARS | C
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| Multi-drug resistant tuberculosis | C
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| Hantavirus | C
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| Salmonella typhimurium | B (oral)
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| gram + rod, soil w/ spores, farm handlers, cutaneous syndrome - skin papules form, rupture, and resolve, inhalation more serious (meningitis, shock)GI uncommon but serious (uncooked meat) vomiting + bloody diarrhea, fluid disreguated (edema, inflammation) | Bacillus antracis
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| ds DNA virus, airborn, sometimes contact spread, incubation 12 days, red spots (enanthem) in mouth, macular rash on skin, micro- Guarnieri bodies in epithelium (pink cytoplasmic aggregates of virus), death unclear - many organs affected; pneumonia and cir | Variola major/minor (smallpox)
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| Gram + rod, rodents,3 forms- pneumonic (cough, hemoptysis), septicemic (hypotension, delerium), bubonic (swollen lymph nodes), fatal w/o treatment or even with due to disseminated intravascular coagulation, endotoxic shock, pneumonia, meningitis | Yersinia pestis (plague)
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| Gram - rod (highly infectious),(rabbit fever)contraction by handling dead bodies, ticks and flies (ulcers), inhalation (pneumonia)antibiotics effective | Francisella tularensis
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| Gram + rod (product of Clostridium botulinum),improperly canned foods, infected wounds, inhibits ACh release (resp failure),Cellulits and gangrene if infected with live bacteriamicro- necrosis, bacteria, neutrophils | Botulinum toxin
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| viral hemorrhagic fever, vascular damage then bleading, reservoir hosts or vectors transmit to humans, deer mice (Hantavirus) west coast,Evola, Marburg, Lassa (Africa)often fatal- disseminated intravascular coagulation | RNA viruses (viral hemorrhagic fever)
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| Protein toxin in castor beans, blocks protein synthesis via ribosomes,diahrrea, organ damage, shock | Ricin
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| Anthrax B-subunit | protective factor
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| Anthrax A-subunit causing cellular water efflux by activating cAMP | Edema factor
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| Anthrax A-subunit protease which destroys mitogen-activated protein kinase kinases | Lethal factor
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| Lesion has necrosis, neutrophils and macrophages, large rectangular gram-positive extracellular bacteria in chains | Antrax
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