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PATHOLOGY
BLOCK 2
| Question | Answer |
|---|---|
| Easily disseminated/transmitted person->person, high mortality -> public health impact, panic/social disruption, requires action for preparation | Category A (High priority) |
| Moderate dissemination, Moderate/Low mortality, Requires increase in CDC diagnostic capacity, Considered Biological Weapons | Category B (Second priority) |
| Easily available,easily produced/disseminated, potential high motality/morbidity/IMPACT, Preparedness requires ongoing research into detection,diagnosis, treatment, prevention | Category C (emerging organisms) |
| Anthrax | A (inhalation) |
| Botulism | A (inhalation) |
| Plague | A |
| Smallpox | A |
| Tularemia | A |
| Viral hemorrhagic fevers (Ebola, Marburg) | A |
| Brucellosis (Brucella) | B |
| Food safety threats (E. coli O157:H7) | B |
| Q fever (Coxiella burnetii) | B |
| Ricin toxin (Ricinus communis - castor beans) | B (percutaneous) |
| Influenza | C |
| SARS | C |
| Multi-drug resistant tuberculosis | C |
| Hantavirus | C |
| Salmonella typhimurium | B (oral) |
| gram + rod, soil w/ spores, farm handlers, cutaneous syndrome - skin papules form, rupture, and resolve, inhalation more serious (meningitis, shock)GI uncommon but serious (uncooked meat) vomiting + bloody diarrhea, fluid disreguated (edema, inflammation) | Bacillus antracis |
| ds DNA virus, airborn, sometimes contact spread, incubation 12 days, red spots (enanthem) in mouth, macular rash on skin, micro- Guarnieri bodies in epithelium (pink cytoplasmic aggregates of virus), death unclear - many organs affected; pneumonia and cir | Variola major/minor (smallpox) |
| Gram + rod, rodents,3 forms- pneumonic (cough, hemoptysis), septicemic (hypotension, delerium), bubonic (swollen lymph nodes), fatal w/o treatment or even with due to disseminated intravascular coagulation, endotoxic shock, pneumonia, meningitis | Yersinia pestis (plague) |
| Gram - rod (highly infectious),(rabbit fever)contraction by handling dead bodies, ticks and flies (ulcers), inhalation (pneumonia)antibiotics effective | Francisella tularensis |
| Gram + rod (product of Clostridium botulinum),improperly canned foods, infected wounds, inhibits ACh release (resp failure),Cellulits and gangrene if infected with live bacteriamicro- necrosis, bacteria, neutrophils | Botulinum toxin |
| viral hemorrhagic fever, vascular damage then bleading, reservoir hosts or vectors transmit to humans, deer mice (Hantavirus) west coast,Evola, Marburg, Lassa (Africa)often fatal- disseminated intravascular coagulation | RNA viruses (viral hemorrhagic fever) |
| Protein toxin in castor beans, blocks protein synthesis via ribosomes,diahrrea, organ damage, shock | Ricin |
| Anthrax B-subunit | protective factor |
| Anthrax A-subunit causing cellular water efflux by activating cAMP | Edema factor |
| Anthrax A-subunit protease which destroys mitogen-activated protein kinase kinases | Lethal factor |
| Lesion has necrosis, neutrophils and macrophages, large rectangular gram-positive extracellular bacteria in chains | Antrax |
Created by:
petrocc
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