Cardiology Boards
Help!
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| QT prolonging drugs | Class Ia, Class III, erythromycin, haldol, cisapride, anti-histamines
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| Class Ia drugs | quinadine, procainamide, disopyramide
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| Class III drugs | sotalal, NAPA, ibutalide, dofetalide, amiodarone
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| Potentiate warfarin effect | amiodarone, propafenone, quinadine, erythromycine
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| antagonize warfarin effect | rifampin, vitamin k, barbiturates
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| increase digoxin levels | amiodarone, quinadine, flecainide, propafenone, verapamil
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| lower digoxin levels | antacides, phenytoin, reglan,
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| drugs affected by grapefruit (increased levels) | statins, terfenidine, felodipine/nifedipine, verapamil,versed, cyclosporine
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| calcineurin inhibitor side effects | HTN, renal insufficiency, hemolytic uremic syndrome (HUS), bone marrow suppression, cushing syndrome
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| cyclosporine side effects | gingival hyperplasia, hirsutism, tremor
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| tacrolimus side effects | glucose intolerance
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| azathiprine | hepatic dysfunction, increased levels with allopurinol (more bone marrow suppression)
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| MMF | GI intolerance, viral infections
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| rapamycin | poor wound healing, oral lesions, hyperlipidemia
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| lipophilic b-blockers metabolized in liver | propranolol, metoprolol, labetolol
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| hydrophilic b-blockers metabolized by kidney | atenolol, nadolol, sotalol
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| Sotalol and dofetilide - mode of elimination | renal elimination antiarrythmics
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| hepatic elimination antiarrythmic meds | quinidine, lidocaine, mexilitine, phenytoin, propafenone, amiodarone, diltiazem
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| drugs that require 50% dose reduction in pts with moderate cirrhosis | warfarin, statin, verapamil/nifedipine, propafenone
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| hepatic metabolism inhibitors | cimetidine, diltiazem, verapamil, erythromycin, anti-fungals
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| hepatic metabolism inducers | barbiturates, carbamezapine, phenytoin, rifampin
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| drugs that increase risk of statin related myopathy | gemfibrozil, niacin, verapamil, amiodarone, CSA, anti-fungals, HIV drugs, grapefruit juice -- decrease dose of statin 50%
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| incidence of rupture with lytics | no increase if lytics given early, but it can occur early if lytics given late (>14 h)
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| absolute contraindications to lytics | any ICH, known AVM, known IC neoplasm, ischemic CVA within 3 months, active bleeding, CHI or facial trauma within 3 months, suspected dissection
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| diabetic retinopathy and menses - contraindication to lytics? | no
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| risk of ICH with different lytics | SK < tPA and TNK < rPA < TNK+LMWH age>75
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| which heparin do you use with lytics? | ONLY UFH
(IIb age <75)
(III age >75)
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| blood thinners to give with lytic therapy | UFH or LMWH (but lower dosing), ASA, Plavix (excluded pts >75 in COMMITT and CLARITY)
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| LMWH in Primary PCI | no role, always use UFH
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| blood thinners to give with primary PCI | UFH, ASA, GPIIb/IIIa (Abciximab), Plavix
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| Class I Recs Primary PCI | MI < 12h, door to balloon < 90 mins
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| Class I Primary PCI for Shock or new LBBB | < 18 hours of shock or <36h h of MI
< 75 years old
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| Supravalvular aortic stenosis | associated with hyperlipidemia and Williams Syndrome
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