flash cards for toxocolgy exams
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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chlorpromazine,Thioridazine,fluphenazine?? | there are antipsychotic drugs phenothiazines
CPZ is least potent ThRZ is most fetalities FPhZ is most potent
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MOA of phenothiazines | 1-dopamine receptor blocker "basal ganglia ,limbic sys "
/2-alpha adrenergic receptor blocker=> postural hypotension& tachcardia
/3-anticholinergic =>mydriasis sinus tachycardia hyperthermia etc
/4-histamine blocker and myocardial depressant
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fatal dose of phenothiazines | 15 to 150mg\kg fetal period hours in acute arrhythmia and it takes days with neuroleptic malignant syndrome
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clinical picture of phenothiazines toxicity "CVS " | 1-hypotention
/2-sinus tachycardia
/3-Av block
/4-Arrhythmia most imp cause of death "ventricular fibrillation"
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clinical picture of phenothiazines toxicity "CNS" | - cns depression ataxia
- hypothermia
- acute dystonia ,parkinsonism ,Tardive dyskinesia
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Neuroleptic malignant syndrome | hyperpyrixia ,
delirium coma,
lead pipe muscle rigidity,
tachycardia and unstable blood pressure
rhabdomyolysis with increased CPKase myoglobinuria
mortality 20%
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