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Toxocolgy FC
flash cards for toxocolgy exams
Term | Definition |
---|---|
chlorpromazine,Thioridazine,fluphenazine?? | there are antipsychotic drugs phenothiazines CPZ is least potent ThRZ is most fetalities FPhZ is most potent |
MOA of phenothiazines | 1-dopamine receptor blocker "basal ganglia ,limbic sys " /2-alpha adrenergic receptor blocker=> postural hypotension& tachcardia /3-anticholinergic =>mydriasis sinus tachycardia hyperthermia etc /4-histamine blocker and myocardial depressant |
fatal dose of phenothiazines | 15 to 150mg\kg fetal period hours in acute arrhythmia and it takes days with neuroleptic malignant syndrome |
clinical picture of phenothiazines toxicity "CVS " | 1-hypotention /2-sinus tachycardia /3-Av block /4-Arrhythmia most imp cause of death "ventricular fibrillation" |
clinical picture of phenothiazines toxicity "CNS" | - cns depression ataxia - hypothermia - acute dystonia ,parkinsonism ,Tardive dyskinesia |
Neuroleptic malignant syndrome | hyperpyrixia , delirium coma, lead pipe muscle rigidity, tachycardia and unstable blood pressure rhabdomyolysis with increased CPKase myoglobinuria mortality 20% |