Acquired Immonodeficiency Syndrome
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| Acquired immunodeficiency syndrome (AIDS) | from 1979-1981 homosexual men showing sx of immunodeficiency-had more than 200 partners each--developed pneumonia due to Pneumocstis carinii--rare ca Kaposi's sarcoma--8-10yrs to develop
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| CD4 cells | helper T cells--eliminated-acquired immunodeficiency results--without these cells memory cells don't develop and other immune cells do not proliferate in response to antigen stimulation
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| Combination therapy | 2 or more drugs used simultaneously-1 drug from each 3 classes used-tx effects greater reduction in viral particles in blood-sometimes virus no longer be detected in blood at all
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| gp 160 | HIV makes surface atachment protein-glycoprotein, 160-160,000 dalton in size-binds to T cell receptor then to coreceptor (CCR5) to infect CD4 cells
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| Human immunodeficiency virus (HIV) | enveloped virion-RNA, 2 copies of genome in each virion--contains reverse transcriptase-integrated viral DNA serves as template for viral transcrption and new RNA molecules incorporated into new virions for release and spread
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| Polyprotein | all viral proteins translated into one--cleaved by specific protease to release individual protein molecules
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| Protease inhibitor | type of antiviral-prevents virus protein from breaking down large viral protein molecules into smaller ones needed for assembly of virions
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| Reverse transcriptase | enzyme can replicate a double strand of DNA from a single strand of RNA
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| Zidovudine (AZT) | 1st of about 5 drugs now available--chemically modified nucleotide is incorporatied into growing DNA-modification designed so no additional nucleotides can be added to DNA-replication terminates at the site without completing whole viral DNA molecule
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Created by:
heatherlvn
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