Exam 16: MSK Drug Review
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| What element is used to decrease inflammation in joints? | Gold
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| What major side effect of Gold is exacerbated by sunlight? | Dermatitis
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| What form of arthritis is where uric acid crystals accumulate in joint? | Gout
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| What medication reduces production of uric acid thus decreasing amounts in joints? | Allopurinol
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| what is Steven-Johnson Syndrome? | A serious and sometimes fatal cutaneous hypersensitivity reaction.
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| What MSK drugs may cause Steven-Johnson Syndrome? | Allopurinol & NSAIDs
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| What types of drugs are used to prevent and treat osteoporosis? | Bone Reabsorption Inhibitors
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| Alendronate, Risedronate & Tilundronate are all examples of what? | biphosphonates
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| What Bone Reabsorption Inhibitor acts like Estrogen? | Raloxifene
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| What medication often given to patients with osteoporossis may inhibit biphosphonate absorption? | calcium
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| What two serum labs are especially important to check on patients receiving alendronate? | serum calcium and serum creatinine.
? (Also Alkaline phosphatase in patients with Paget’s disease. Just sayin...)
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| What are common side effects of bisphosphonates? | Bone pain, GI distress, nausea/diarhea and metallic taste in the mouth.
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| When should you administer Alendronate po? | At least 30 minutes before meals with an 8 ounce glass of water. Have patient upright for at least 30 minutes to prevent GI distress (reflux).
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| Why should patients on raloxifene stop taking their meds for prolonged periods of immobilization? | Increased risk of blood clots.
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| Which class of anti-rheumatic drugs slow down joint destruction? | DMARDS
(Eg. Enbrel and Remicade)
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| Bacolefen, Fleceril, Valium and Paraflex are all examples of... | Muscle Relaxants
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| Do not drive or perform any hazardous activity while on either of these medications | muscle relaxant or narcotic
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| What natural hormone that has anti-inflammatory effects and can be given in a synthetic form | Corticosteroids
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| What are side effects of Corticosteroids? | Hump back, moon face, weight gain, oily skin.
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| What are dangerous or life threatening complications of steroid therapy? | osteoporosis, masking infection, diabetes and bleeding ulcers
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| What serum electrolyte is most affected by steroids? | Serum Potassium
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| What are the signs of adrenal insufficiency? | Hypotension, weight loss, muscle weakness, n/v, anorexia, lethargy, confusion, and restlessness.
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| Which muscle relaxer acts directly on skeletel muscle? | Dantrolene
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| What is Salicylism? | Dizziness, Tinnitus, Hyperventilation, Flushing, Sweating, Impaired hearing
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| What are the three main actions of Salicylates, NSAIDs? | Antipyretic, Analgesic, Anti-inflammatory
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| What is an analgesic? | Pain Reliever
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| What are names of some common NSAIDs? | Ibuprofen, Celebrex, Vioxx, Motrin, Naprosyn
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| Which non-narcotic analgesic does not have anti-inflammatories? | Acetaminophen (Tylenol)
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| What non-narcotic analgesic has a major side effect of GI bleeding? | Salicylates
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| Which Salicylate decreases the risk of MI and TIA? | Aspirin
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| Which non narcotic analgesic has the major side effect of hepatotoxicity/hepatic failure? | Acetaminophen
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| What syndrome is caused by giving salicylates to children with viral infections? | Reye's Syndrome
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| Due to bleeding issues, do not take these 2 types of nonnarcotic analgesics together? | Salicylates and NSAIDS
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| What are uses of narcotic analgesics? | Pain relief, severe cough, anxiety, sedation, detox
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| What is the major side effect of narcotic analgesics? | Respiratory Depression
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| Which medication reverses the respiratory depression of narcotic agents? | Narcan
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