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Glomerulonephritis, Acute RF and Chronic RF

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Sign/Symptom
Pathology
Smoky haematuria, proteinuria, hypertension, some kidney impairment and some oedema   Nephritic Syndrome  
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Heavy proteinuria, hypoalbuminaemia, oedema, hyperlipidaemia   Nephrotic Syndrome  
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Nephrotic syndrome with a bland urine sediment   Minimal change GN, diabetic nephropathy or amyloid deposition  
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Renal failure occuring over a few months with active urine sediment   Rapidly progressive GN  
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The most common cause of nephritic syndrome in children. Is due to an immune-directed circulating factor that causes the glomeruli to leak. Bland urine sediment and normal glomeruli under light microscopy   Minimal Change Disease  
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Nephrotic syndrome in adults due to a circulating immune-directed permeability factor. Sclerosis occurs in some parts of some glomuerli. Treatment with prednisolone usually doesn't work   Focal Segmental Glomerulonephritis  
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The most common cause of nephrotic syndrome in adults. It can be caused by antibodies, systemic lupus erythematosus and drugs.   Membranous Glomerulonephritis  
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One of the most common causes of GN. Can occur at the same time as pharyngitis.   IgA Glomerulonephritis  
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A nephritic syndrome that occurs after an infection with certain strains of Strep, usually in children. Proliferation with immune complex deposition. If the antigen is removed, they get better.   Post-infectious Glomerulonephritis  
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A systemic autoimmune disease that usually occurs in young women and presents with a butterfly rash.   Lupus Nephritis  
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Autoimmunity with autoantibodies to neutrophil proteins causing vasculitis in the lungs and kidneys. The neutrophils damage the basement membranes and cause severe necrosis.   ANCA-associated Glomerulonephritis  
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Autoimmunity with autoantibodies to a structural collagen in the basement membranes of the kidneys and lungs. Results in cresent formation and rapidly progressive GN with lung haemorrhage.   Anti-Glomerular Basement Membrane Glomerulonephritis (GOODPASTURE'S DISEASE)  
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Renal failure caused by shock and renal artery stenosis (TRIPLE WHAMMY)   Pre-renal acute renal failure  
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Renal failure caused by bladder outflow obstruction, urethral stricture, ureteric obstruction or congential PUJ obstruction   Post-renal acute renal failure  
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A tubulointerstitial, renal cause of ARF. It can be either toxic or ischaemic (from unresolved pre-renal ARF). Characterised by a bland urinary sediment and oliguria.   Acute tubular necrosis  
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A tubulointerstitial cause of renal ARF. An inflammatory reaction that is usually in response to drugs (eg. antimicrobials, NSAIDs, diuretics). Eosinophil infiltration causes renal impairment.   Acute or Chronic Interstitial Nephritis  
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A glomerular cause of renal ARF that is associated with glomerulosclerosis and arteriosclerosis.   Diabetic nephropathy  
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A complicating factor of vascular, renal ARF.   Hypertension  
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A vascular cause of renal ARF characterised by the inflammation and necrosis of blood vessels by 'rogue' immune cells   Polyarteritis  
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A vascular cause of renal ARF that is due to cholesterol release from an atheromatous plaque. There are increased inflammatory markers.   Cholesterol athero-embolism (CE)  
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Increases the tone of the afferent (lesser) and efferent (greater) arterioles.   Angiotensin II  
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Maintains normal afferent tone to prevent it from constricting fully.   Prostacyclins  
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50% or more of kidney function   Normal creatinine  
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Less than 50% of kidney function   Elevated creatinine  
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15% residual GFR (urea >40mmol/L)   Uraemia  
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<10% residual GFR   End-stage renal failure  
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The most common cause of chronic renal failure in Australia.   Diabetic nephropathy  
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Can be caused by ANCA glomerulonephritis, anti-glomerular basement membrane nephritis or systemic lupus erythematosus. Presents as crescenteric glomerulonephritis.   Rapidly progressive glomerulonephritis  
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Most common cause of UTIs   E.Coli - gram negative bacilli  
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Factor that increases risk of calculi formation   Urease - staph, proteus, pseudomonas  
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Antibiotic used for UTIs   Trimethoprim (NEVER amoxicillin)for 3-5 days (uncomplicated) or 10-14 days (pyelonephritis)  
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Investigation for UTI in males, children or pyelonephritis   Renal tract ultrasound  
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Investigation for first time UTI in female   None  
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Treatment for recurrent UTIs   Prophylactic or intermittent antibiotics  
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Recurrent UTIs in men   Chronic prostatitis  
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