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USMLE Step 1

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Drug
MOA & ADRs
Metaproterenol   MOA: Beta-2 agonist used for mild, intermittent asthma, rapid onset & provide relief for 4-6 hrs, potent bronchodilators, not destroyed by COMT; ADRs: little beta-1 effect, but can cause cardiac stimulation resulting in heart palpitations  
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Terbutaline   MOA: Beta-2 agonist used for mild, intermittent asthma, rapid onset & provide relief for 4-6 hrs, potent bronchodilators, not destroyed by COMT; ADRs: little beta-1 effect, but can cause cardiac stimulation resulting in heart palpitations  
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Albuterol   MOA: Beta-2 agonist used for mild, intermittent asthma, rapid onset & provide relief for 4-6 hrs, potent bronchodilators, not destroyed by COMT; ADRs: little beta-1 effect, but can cause cardiac stimulation resulting in heart palpitations  
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Cromolyn   MOA: used for prophylaxis of moderate asthma that is a mast cell stabilizer & NOT useful for acute attacks, ADRs: bitter taste, as well as irritation of the larynx & pharynx  
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Beclomethazone   MOA: Corticosteroid for severe, chronic asthma serves to decrease activation of macrophages, eosinophils & T cells, reverse mucosal edema, decrease capillary permeability & - release of leukotrienes; *Note 80% PO metabolized by liver, spacer used*  
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Triamcinolone   MOA: Corticosteroid for severe, chronic asthma serves to decrease activation of macrophages, eosinophils & T cells, reverse mucosal edema, decrease capillary permeability & - release of leukotrienes; *Note 80% PO metabolized by liver, spacer used*  
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Flunisolide   MOA: Corticosteroid for severe, chronic asthma serves to decrease activation of macrophages, eosinophils & T cells, reverse mucosal edema, decrease capillary permeability & - release of leukotrienes; *Note 80% PO metabolized by liver, spacer used*  
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Theophylline   MOA: Phosphodiesterase - that increases the amt of Ca, it is used for more severe asthma; ADRs: not freq used b/c many interactions w/ wide range of drugs, thus has a low therapeutic index, causes seizures and/or fatal arrhythmias  
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Zileuton   MOA: leukotriene - (direct inhibition of lipoxygenase) decrease bronchoconstriction txing the sx, thus not 1st-line drugs in tx of asthma  
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Zafirlukast   MOA: leukotriene - (leukotriene receptor blocker) decrease bronchoconstriction txing the sx, thus not 1st-line drugs in tx of asthma  
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Montelukast   MOA: leukotriene - (leukotriene receptor blocker) decrease bronchoconstriction txing the sx, thus not 1st-line drugs in tx of asthma  
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Methylprednisone   MOA: IV used for 'Status asthmaticus' a severe, unrelenting exacerbation of asthma  
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Prednisone   MOA: PO used for 'Status asthmaticus' a severe, unrelenting exacerbation of asthma  
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Epinephrine   MOA: acute anaphylactic shock (Type 1 Hypersensitivity)  
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