Immunity
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| Immunity | INNATE IMMUNITY
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| What is Immunity? | Ability to resist damage from foreign substances as microorganisms and harmful chemicals
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| Innate Immunity | -Innate or nonspecific resistance
=Mechanical mechanisms: Prevent entry or remove microbes
=Chemical mediators: Promote phagocytosis and inflammation
-Cells: Involved in phagocytosis and production of chemicals
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| Adaptive or specific immunity | Specificity: Ability to recognize a particular substance
Memory: Ability to remember previous encounters with a particular substance and respond rapidly
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| Inflammatory Response --Tissue injury regardless of type can cause inflammation | Response initiated by chemical mediators that produce vasodilation, chemotactic attraction, increased vascular permeability
Types
-Local: Symptoms are redness, heat, swelling, pain, loss of functn
-Systemic: Symptoms are increase in neutrophil numbers,
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| Innate Immunity: Cells | -White blood cells
Most important cellular components of immune system
-Methods
*Chemotaxis
*Phagocytosis
*Neutrophils
-Phagocytic and first cells to enter infected tissue
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| Innate Immunity Cells II | -Macrophages
-Monocytes that leave blood, enter tissues
-Large phagocytic cells
-Basophils and mast cells
>Promote inflammation
-Eosinophils
>Reduce inflammation
-Natural killer cells
>Lyse tumor and virus-infected cells
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| Antigenic Determinants | -Antigenic determinants
=Specific regions of a given antigen recognized by a lymphocyte
-Antigenic receptors
=Surface of lymphocyte that combines with antigenic determinant
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