Pharm2FinalXCV
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| LSD | Hallucinogen
Lysergic Diethylamide
Extremely potent-25-500mcg dose
Initial effects-giddy start in 30min-2hr
Psychogenic, 1-3hrs
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| Psilocin | Hallucinogen
Like LSD but in mushrooms.
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| Bufotenin | Hallucinogen
Toad Licking
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| Mescaline | Hallucinogen
Found in cactus
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| MDMA | Hallucinogen
And stimulant
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| Ibogaine | Hallucinogen
Powerful-found in tabernathe african shrub
May suppress heroin craving
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| Phencyclidine | PCP
hyperfelxia and vertical nystagmus when overdosed
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| Riluzole | ALS
Lou gherigs disease.
orphan drug
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| N2O gas | GA
MAC 105, cant put to sleep, sedation at 30%.
Can change BP, dental anesthetic
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| Enflurane | GA
contraindicated for epileptics
May cause seizures
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| Isoflurane | GA
Lowers bp
Vasodialation
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| Desflurane | GA
Irritating Gas, cough
Must use IV GA
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| Sevoflurane | GA
99% eliminated through the lungs
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| MAC | Concentration of inhaled gas needed to work in 50% of patients
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| Propofol | IV GA
Rapid acting, <1min
Maybe Killed MJ
Most common agent in US
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| Etomidate | IV GA
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| Ketamine | IV GA
Profound analgesia, used in battlefield
Emergence delirium
increase BP
decrease ventilation, bronchodialator
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| GA Adjuncts | Midazolam, pre op sedation and amnesia
Opioids
Fentanyl- complete incapacitation
Dexmedeomidine- a2 agonist, sedates
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| Dantrolene | Treats Malignant Hyperthermia
Muscles contract since rayonidine channels wont close. produces heat (108) and kills people.
inhibits ryanodine receptors
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| Rocuronium | NMJ Blocker
Rapid acting, 1-2min relaxe laranx and jaw for intubation
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| Atracurium | NMJ Blocker
not metabolized by enzymes, good for ppl with liver/renal failure
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| Succinylcholine | NMJ Blocker
opens NA channels and keeps them open
causes fasiculations
used for intubation
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| Epinephrine | Increases LA effects
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| Lidocaine | Amide LA
Most widely used
infiltration, nerve bock, epidural
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| Bupivacaine | Amide LA
Longer duration of action
Used during labor
cardiotoxic if iv
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| Ropivacaine | Amide LA
least motor effect.
Useful in labor
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| Articane | Amide LA
rapidly metabolized
LA of choice for dentists
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| Benzocaine | Ester LA
topical only
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| Cocaine Hydrochloride | Ester LA
vasoconstrictive effects.
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| Reloxifene | SERM
Estrogen agonist in bone to treat osteoporosis
can cause thromboembolism and vasomotor symptoms
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| Clomiphene Citrate | Estrogen antagonist
Induces ovulation in infertile women. Promotes FSH and LH
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| Leuprolide | GnRH Agonist
treats androgen dependent prostate cancer, endometriosis, precocious puberty
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| Gonadotropins, menotropins | Increase fertility
Spermatogenesis and ovulation
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| Oxytocin | Stimulates uterine contraction, milk release
bonds to its receptor and causes calcium release in myometrial smooth muscle
Estrogen increases oxytocin receptors
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| Dinoprostone | Prostaglandin for inducing pregnancy
ripens uterus
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| Carboprost | Treats postpartum bleeding and can induce abortion in 2nd trimester
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| Misoprostol | Can terminate pregnancy with antiprogestin
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| Ergot Alkyloids | Cause strong uterine contractions
Not used to induce labor, could kill the child
Treats hemoraging
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| Terbutaline sulfate | B2 agonist
stops uterine contractions
increases cAMP
not for diabetics
receptors rapidly desensitize
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| Indomethicin | Stops prostaglandin synthesis
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| Mechlorethamine | Anti-cancer
alkylizes N7 position on guanine, damages DNA in proliferative cells.
Made from mustard gas, earliest agent
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| Cyclophosphamide | Alkylizing agent
Longer half life than mustard drug
immunosupressive
treats wider range of cancers
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| Carmustine | Alkylating agent
Nitrosourea
Can treat brain tumors lipid soluble
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| Cisplatine | Alkylating Agent
Platinum compound
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| Methotrexate | Antimetabolite
S phase
Inhibits dihydrofolate reductase
Blocks ability to make deoxyuridylate and thymidylate
Leucovorin bipasses need for this and protects normal cells.
Also for psoriasis and RA
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| Mercaptopurine | Antimetabolite
inhibits purine sythesis
S phase
metabolized by xanthium oxidase which is inhibited by allopurinol
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| Dox/Daunorubicin | Natural Anticancer
come from streptomyces
bind to DNA via intercalation
Uncoil DNA
Can cause CARDIOMYOPATHYYYYYYYy
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| Vinblastine/Vincristine | Natural Anticancer
M phase specific
disrupt mitotic spindle
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| Etoposide | Natural Anticancer
Breaks DNA, G2 phase
Semisynthetic podophyllotoxin
FOR THE NUT
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| Dexamethasone/Prednisone | Anticancer steroids
suppresses mitosis
Cushing's syndrome
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| Tamoxifen | Hormonal anticancer
Antiestrogen
for ER positive breast cancer
male breast cancer
Causes menopasal symptoms
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| Imatinib Mesylte | Inhibits tyrosine kinase in BCR-Abl positive leukemia cells
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| Trastuzumab | anitbody for da boobeez.
EGF
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Created by:
amarche1
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