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Allergic Asthma, Jackson, 1/11

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Question
Answer
Define Asthma   A chronic, common, persistent inflammatory disease of the airways characterized by reversible airway obstruction, airway inflammation, airway hyperresponsiveness and airway remodeling  
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Extrinsic (or Atopic asthma) key characteristics   Develops early in life, allergy coexists, family history of atopy, attacks associated with seasonal allergies, Total serum IgE is elevated  
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Intrisic (or Idiopathic asthma) key characteristics   Appears later in life, not associated with allergy or IgE, Blood and sputum eosinophilia, less common than atopic  
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Nonspecific Asthma triggers   Infections, Physiologic factors (exercise, hyperventilation, deep breathing), atmospheric factors, Ingestants, Laughter  
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Signs of acute asthma   Cough, Tachypnea, Wheezing (most often in expiration), Use of accessory muscles of respiration, rapid pulse, lung fields are hyperresonant  
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An atopic asthmatic has more of a ___ response than normal   Th2  
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Contributors to inflammatory response in asthmatic   Increased mucous production, basement membrane thickening, angiogenesis, lamina propria thickens, Vagal stimulation  
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Which factor stimulates Mast cells   IgE  
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Which factor is most long acting in asthma bronchoconstriction and therefor a target of some drugs   Leukotriens  
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What do chemotactic factors and cell adhesion molecules do in asthma?   Set up a gradient to increase cell mobility of inflammatory cell infiltration  
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IL stimulated by the Th2 produce   IgE  
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Mucous plugging   Excessive mucous in asthma that can lead to death  
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Histamine   Causes early vasodilation and brochoconstriction, very transient, released from mast cells  
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Asthma patient management   Objective measure of lung function, avoid triggers, drug therapy, education, plan for managing exacerbation, provide follow-up care, OMT  
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