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Asthma- Jackson

Allergic Asthma, Jackson, 1/11

Define Asthma A chronic, common, persistent inflammatory disease of the airways characterized by reversible airway obstruction, airway inflammation, airway hyperresponsiveness and airway remodeling
Extrinsic (or Atopic asthma) key characteristics Develops early in life, allergy coexists, family history of atopy, attacks associated with seasonal allergies, Total serum IgE is elevated
Intrisic (or Idiopathic asthma) key characteristics Appears later in life, not associated with allergy or IgE, Blood and sputum eosinophilia, less common than atopic
Nonspecific Asthma triggers Infections, Physiologic factors (exercise, hyperventilation, deep breathing), atmospheric factors, Ingestants, Laughter
Signs of acute asthma Cough, Tachypnea, Wheezing (most often in expiration), Use of accessory muscles of respiration, rapid pulse, lung fields are hyperresonant
An atopic asthmatic has more of a ___ response than normal Th2
Contributors to inflammatory response in asthmatic Increased mucous production, basement membrane thickening, angiogenesis, lamina propria thickens, Vagal stimulation
Which factor stimulates Mast cells IgE
Which factor is most long acting in asthma bronchoconstriction and therefor a target of some drugs Leukotriens
What do chemotactic factors and cell adhesion molecules do in asthma? Set up a gradient to increase cell mobility of inflammatory cell infiltration
IL stimulated by the Th2 produce IgE
Mucous plugging Excessive mucous in asthma that can lead to death
Histamine Causes early vasodilation and brochoconstriction, very transient, released from mast cells
Asthma patient management Objective measure of lung function, avoid triggers, drug therapy, education, plan for managing exacerbation, provide follow-up care, OMT
Created by: mcasto