Pathophysiology Unit 5
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
---|---|---|---|---|---|
Steatorrhea | greasy, loose stools
🗑
|
||||
Melena | tarry stools caused by bleeding
🗑
|
||||
Dysphagia | difficulty swallowing
🗑
|
||||
Antiemetic | drug used to decrease nausea and vomiting
🗑
|
||||
Anorexia | loss of appetite
🗑
|
||||
Hematemesis | vomit containing blood
🗑
|
||||
Impaction | retention of feces
🗑
|
||||
Candidiasis | opportunistic oral fungal infection
🗑
|
||||
Gingivitis | inflammation of tissue surrounding teeth
🗑
|
||||
Cholelithiasis | formation of gallstones
🗑
|
||||
Diverticulum | outpouching of mucosa in the colon
🗑
|
||||
Causes of vomiting | distention/irritation of GI tract, unpleasant sights or smells, pain or stress, stimulation of vestibular apparatus in inner ear (motion sickness), increased intracranial pressure, stimulation of chemoreceptor trigger zone
🗑
|
||||
Measures used to decrease vomiting | treat cause (analgesics for pain, laxitives/enema); antiemetic drugs, sedatives, antacids, ventilation to remove odors
🗑
|
||||
Cause of constipation | inadequate dietary fiber
🗑
|
||||
Cause of constipation | inadequate fluid intake
🗑
|
||||
Cause of constipation | failure to respond to defecation reflex
🗑
|
||||
Cause of constipation | muscle weakness, inactivity
🗑
|
||||
Cause of constipation | neuro disorders like MS, spinal cord trauma
🗑
|
||||
Cause of constipation | drugs i.e. opiates, CNS depressants, anti-cholinergics
🗑
|
||||
Cause of constipation | some antacids, iron meds, and bulk laxatives w/ insufficient fluid intake
🗑
|
||||
Cause of constipation | obstruction caused by tumors or strictures
🗑
|
||||
Ways to relieve chronic constipation | increased fiber and fluid intake
🗑
|
||||
Causes of dysphagia | esophageal fibrosis, compression, diverticulum, congenital atresia, tracheoesophageal fistula, neuro damage to cranial nerves V, VII, IX, X, and XII, echolalia
🗑
|
||||
Hiatal hernia | part of stomach is elevated and protrudes through opening in diaphragm into thoracic cavity
🗑
|
||||
Hiatal hernia | postprandial heartburn or pyrosis, brief substernal burning sensation w/ sour taste, belching, vomiting, dysphagia
🗑
|
||||
Treatment of hiatal hernia | eliminating factors that reduce LES pressure like caffeine, fatty foods, alcohol, cigarette smoking, and certain drugs
🗑
|
||||
GERD (gastroesophageal reflux disease) | periodic flow of gastric contents into esophagus; caused by hiatal hernia as well as other conditions that lower LE pressure or increase intra-abdominal pressure
🗑
|
||||
Meds that treat GERD | Antacids, histamine2 (H2 receptor) antagonists, proton pump inhibitors
🗑
|
||||
Acute gastritis | inflammation of the gastric mucosa due to variety of causes including infection, food/drug allergy, ingestion of spicy/irritating food, excessive alcohol intake, aspirin or other acrogenic drugs, toxic substances, radiation, chemotherapy
🗑
|
||||
Acute gastroenteritis | inflammation of both the stomach and intestine usually caused by infection but may result from food/drug allergies
🗑
|
||||
Chronic gastritis | inflammation of gastric mucosa caused by peptic ulcers, alcohol abuse, aging, pernicious anemia; causes epigastric discomfort and intolerance of spicy foods
🗑
|
||||
Proximal duodenum, antrum of stomach, lower esophagus | locations where ulcers occur
🗑
|
||||
Factors contribute to peptic ulcers | decreased mucosal resistance, excessive HCl or pepsin secretion, and presence of H. pylori
🗑
|
||||
Pathophysiology of peptic ulcers | acid/pepsin penetrates mucosal barrier, expose tissue to continued damage b/c of acid diffusion into gastric wall; may erode more deeply into muscle layers and perforate; inflammation and bleeding surround when blood vessel involved
🗑
|
||||
Complications of peptic ulcers | perforation leading to chemical peritonitis and eventually bacterial peritonitis; obstruction of GI tract due to scarring and stricture formation
🗑
|
||||
Symptoms/manifestations of peptic ulcers | epigastric burning/pain usually 2 to 4 hours after meals and at night, heartburn, nausea, vomiting, weight loss, iron deficiency anemia or occult blood in stool
🗑
|
||||
Ulcer treatments | drug therapy of combo of antimicrobials and acid reducers; coating agents or antacids for symptomatic relief; reducing exacerbating factors; vagotomy, partial gasterctomy or pyloroplasty in pt with perforation/bleeding
🗑
|
||||
Individuals at high risk for gallstones | women with high cholesterol in bile; obesity, high cholesterol intake, multiparity; use of birth control or estrogen supplements; indivs with hemolytic anemia, alcoholic cirrhosis, or biliary tract infections
🗑
|
||||
Manifestations of gallstones | sudden severe waves of pain in upper right quadrant of abdomen or epigastric area, often radiating to back or right shoulder; nausea and vomiting, increasing and decreasing pain followed by jaundice
🗑
|
||||
Disorders that cause jaundice | prehepatic, intrahepatic, and posthepatic disorders
🗑
|
||||
Prehepatic disorders | cause of jaundice; results from excessive destruction of RBCs, i.e. physiologic jaundice of some newborns, hemolytic anemias, transfusion reactions
🗑
|
||||
Intrahepatic disorders | cause of jaundice; due to liver disease resulting in impaired uptake of bilirubin from blood and decreased bilirubin conjugation; i.e. indivs with liver disease like hep or cirrhosis
🗑
|
||||
Posthepatic disorders | cause of jaundice; obstruction of biliary flow due to congenital atresia of bile ducts, cholelithiasis, inflammation/tumors of liver
🗑
|
||||
Causes of nonviral hepatitis | infectious mononucleosis or amebiasis
🗑
|
||||
Hepatitis A | RNA virus; oral-fecal enteric transmit; ppl in large institutions @ risk, children w/ poor hygiene, lower income grps, travelers to developing countries, oral/anal sex; incubation 2-6 wks, mild symptoms (jaundice); duration manifest 2 months
🗑
|
||||
Hepatitis B | HBV double stranded DNA virus; blood/body fluid transmission; drug users, unprotected sex, hemodialysis pts, infants born to infected moms, tattooing/piercing, health profs, blood transfustion prior to 1984; 1-6 mo incubation; symps severe; lasts 4-12 wks
🗑
|
||||
Hepatitis C | HCV RNA virus; blood/body fluid transmit; drug users, unprotected sex, hemodialysis, infants born to pos. moms; tattooing/piercing, health prof, blood transfusion before '90; organ recipients, insemination; incubates 2 wk – 6 mo; asymptomatic; 2-12 wks
🗑
|
||||
Hep B, Hep C | hepatitis carrier states
🗑
|
||||
Rare | hep A complications?
🗑
|
||||
Hep B complications | chronicity, hepatocellular carcinoma, cirrhosis and liver failure, fulminant hepatitis
🗑
|
||||
Hep C complications | chronicity (more than 50%); hepatocellular cancer, cirrhosis and liver failure
🗑
|
||||
Serological marker for Hep A | anti HAV IgM indicates acute infection; anti HAV IgG indicative of past exposure
🗑
|
||||
Serological marker for Hep B | HbsAG indicates infection; Anti HBs indicate recovery and noninfection w/ effective protection; HbeAg
🗑
|
||||
Serological marker for Hep C | anti HCV shows nonprotective infection; HCV RNA shows active infection
🗑
|
||||
Hep A | hepatitis that has no medication treatment
🗑
|
||||
Treatment for Hep B | chronic cases with abnormal liver function tests can be treated w/ interferon alpha 2b, lamivudine
🗑
|
||||
Treatment for Hep C | with elevated ALT treated with interferon alpha 2b, ribavirin
🗑
|
||||
Fecal oral route | route of infection from virus contaminated stool/food/fomites to hands to mouth and fomites by poor hygiene, unsanitary toilet practices
🗑
|
||||
Incomplete RNA virus that requires presence of HBV to replicate | why Hep D occurs only in pt who have Hep B
🗑
|
||||
Serological markers | how Hep D infection can be detected if pt also has hep B
🗑
|
||||
Fecal-oral route | how is hep E contracted?
🗑
|
||||
Stages of hepatitis | preicteric stage, icteric stage, posticteric stage
🗑
|
||||
Preicteric stage | stage of hepatitis; fatigue and malaise, anorexia and nausea, and general muscle aching; elevated serum levels of liver enzymes (AST, ALT)
🗑
|
||||
Icteric stage | stage of hepatitis; jaundice; light-colored stool; dark urine and pruritic skin; tender, enlarged liver, causing mild aching pain; blood clotting times elevated in severe cases
🗑
|
||||
Posticteric stage | stage of hepatitis; reduction in signs, may last for several weeks; depending on specific viral etiology
🗑
|
||||
Info needed from pt with hepatitis | date of diagnosis, type, ever told not to give blood, carrier status, meds
🗑
|
||||
Cirrhosis | progressive destruction of liver tissue eventually leading to liver failure
🗑
|
||||
Causes of cirrhosis | alcoholic liver disease, biliary cirrhosis due to immune disorders, stones, cystic fibrosis; chronic hepatitis or long-term exposure to chemicals
🗑
|
||||
Pathophysiology of cirrhosis | liver fibrosis, loss of lobular organization; nodules of hepatocytes poss. present & nonworking b/c of distorted vascular and biliary network; fibrosis interferes w/ blood supply, back up bile causes inflammation/damage; liver becomes scarred and shrunken
🗑
|
||||
Liver function lost/impaired with cirrhosis | decreased removal and conjugation of bilirubin
🗑
|
||||
Liver function lost/impaired with cirrhosis | decreased bile production
🗑
|
||||
Liver function lost/impaired with cirrhosis | impaired digestion and absorption of nutrients, esp fat and fat soluble vitamins
🗑
|
||||
Liver function lost/impaired with cirrhosis | impaired glucose/glycogen metabolism
🗑
|
||||
Liver function lost/impaired with cirrhosis | inadequate storage of iron, vit. B12
🗑
|
||||
Liver function lost/impaired with cirrhosis | decreased inactivation of hormones, esp aldosterone and estrogen
🗑
|
||||
Liver function lost/impaired with cirrhosis | decreased removal of toxic substances from blood
🗑
|
||||
Manifestations of cirrhosis | Fatigue, anorexia; ascites; edema; esophageal varices, hemorrhoids; splenomegaly; anemia; Leukopenia, thrombocytopenia; increased bleeding, purpura; hepatic encephalopathy, tremors, confusion; gynecomastia, impotence, irregular menses; jaundice, pruritis
🗑
|
||||
Portal hypertension | blockage of blood flow through liver leading to high pressure in portal veins
🗑
|
||||
Complications of portal hypertension | ascites, splenomegaly, esophageal varices; impaired respiration, increased risk of peritonitis, impaired digestion and absorption
🗑
|
||||
Treatments/interventions for cirrhosis | supporting/symptomatic trtmt avoiding fatigue & exposure to infections; dietary restrictions on protein/sodium; high carb intake, vit supplements; diuretics; paracentisis; albumin transufions, antimicrobials, transplant
🗑
|
||||
Cause of acute pancreatitis | gallstones and alcohol abuse
🗑
|
||||
Pathophysiology of acute pancreatitis | premature activation of pancreatic enzymes w/ autodigestion of pancreatic tissue; tissue necrosis w/ severe inflammation of pancreas; enzymes leak into gen circulation and cause shock, intravascular coagulation, respiratory distress syndrome; peritonitis
🗑
|
||||
Manifestations of pancreatitis | severe epigastric or abdominal pain radiating to the back; increases when supine; signs of shock
🗑
|
||||
treatment of pancreatitis | stopping all oral intake; relieving bowel distention; treating shock and electrolyte imbalances; and prescribing analgesics but NOT morphine
🗑
|
||||
celiac disease | Malabsorption syndrome, primarily in childhood; genetic factors resulting in defect in intestinal enzymes need to complete digestion of gliadin, a breakdown product of gluten
🗑
|
||||
pathophysiology of celiac disease | combo of digestive block with immunologic response results in a toxic effect on the intestinal villi; villi atrophy resulting in decreased enzyme production and reduced surface area for absorption of nutrients, resulting in malabsorption and malnutrition
🗑
|
||||
characteristics of malabsorption syndromes | steatorrhea, muscle wasting, failure to gain weight, irritability, malaise
🗑
|
||||
treatment of celiac disease | adopting gluten free diet, avoiding grains like wheat, barley, oats
🗑
|
||||
pathophysiology of appendicitis | obstruction of appendiceal lumen by fecalith, gallstone, foreign material, twisting, spasm; fluid buildup, inflammation, swelling, ischemia & necrosis; bacteria & toxins cause bacterial peritonitis; rupture/perforation can release contents into peritoneum
🗑
|
||||
acute appendicitis manifestations | periumbilical pain, nausea/vomiting, increasing LRQ pain/tenderness with steady, severe abdomen pain; low grade fever, onset of peritonitis include rigid abdomen, tachycardia, hypotension
🗑
|
||||
chronic inflammatory bowel disease | crohn’s disease and ulcerative colitis of unknown etiology
🗑
|
||||
crohn’s disease | Ashkenazi Jews, whites @ risk; familial tendency etiology; lesions of TI; transmural skip lesions/granules; malabsorption, steatorrhea, adhesions/strictures, fistulas,fissures, loose/semiformed stool, melena, cramping, weight loss, fatigue, delayed growth
🗑
|
||||
ulcerative colitis | whites, Ashkenazi jews, young adults; high familial tendency; lesions in colon and rectum of mucosa with continuous ulcerations; malabsorption, toxic megacolon, obstruction, iron anemia; frequent watery stools, blood, mucus, cramping, fever, weight loss
🗑
|
||||
treatment of inflammatory bowel disease | identification and removal of stressors, anti-inflammatory meds, antimotility agents, nutritional substances, antimicrobials, immunotherapeutic agents, and surgical resection of affected areas
🗑
|
||||
diverticulitis | inflammation of diverticula
🗑
|
||||
warning signs of colorectal cancer | signs depend on location in colon
🗑
|
||||
ascending colon cancer signs | liquid stool, occult blood/melena, anemia, fatigue, late palpable mass
🗑
|
||||
transverse colon cancer signs | semisolid stool, anemia, occult blood, change in bowel habits
🗑
|
||||
descending colon cancer signs | solid stood, constipation, discomfort, abdominal fullness and distention, red or dark blood in stool
🗑
|
||||
rectum cancer signs | solid stool, abdominal discomfort and cramps; ribbon or pellet stool, incomplete emptying, red blood on surface of stool
🗑
|
||||
causes of intestinal obstruction | mechanical issues due to tumors, adhesions, hernias or functional issues like adynamic obstruction b/c of neuro impairment, paralytic ileus
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
michellerogers
Popular Science sets