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Cardioactive, Vasoactive, Sympathomimetics, Sympatholytics

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Drug Name
Class/Effects/Action
Phenylephrine   sympathomimetic (alpha-1 agonist) tx-HT, nasal congestion  
Beclomethasone   corticosteroid - inhaled (less systemic side effects)  
Clonidine   sympathomimetic - alpha 2 agonist. tx-HT  
Theophylline   long acting bronchodilator (phosphodiesterase inhibitor) tx-asthma  
Terbutaline   sympathomimetic - beta 2 agonist. tx-asthma, emphysema  
Metoprolol   sympatholytic - beta 1 blocker (agonist) tx-HT  
Yohimbine   sympatholytic - alpha 2 antgonist. tx-erectile dys. produce mydriasis  
prazosin   sympatholytic - alpha 1 blocker (antagonist) tx-HT  
Dobutamine   sympathomimetic - beta 1 agonist. tx-cardiac decomposition  
Fluticasone   corticosteroid (inhaled) - less systemic side effects  
Prednisone   corticosteroid (systemic)  
Four classes of long acting bronchodilators   1. inflammatory mediators inhibitor 2. beta adrinergic agonists 3. leukotriene antagonists 4. phosphodiesterase inhibitors  
mediators that actively constrict smooth muscle (4)   histamine, seratonin, platelet activating factor, leukotrienes  
receptors that NE and Epi act on   beta 1 and 2; alpha 1 and 2 adrinergic receptors  
receptors that Ach acts on & ultimate effect in the airway   M1 and M2 receptors (smooth muscle contraction in airway)  
Digoxin   cardiac glycoside - increases contractlity by increasing intracellular [Ca++] tx-heart failure  
Dopamine   Dopamine agonist low doses: incr. CO, TPR, venous tone. High doses: incr. TPR, pulmonary vascular resistance, produces vasoconstriction  
positive inotropes   improve cardiac function by increasing contractility. drug classes: beta adrinergic, dopamine agonists, phosphodiesterase inhibitors, cardiac glycosides tx-heart failure  
cardiac antihypertensives   decrease afterload of heart. beta blockers, Ca++ channel blockers tx-HT, heart failure  
beta adrinergic agonists - prototype drugs (3)   isoproteronol (B1 and 2), Dobutamine (B1), Terbutaline (B2)  
Dobutamine   Beta 1 adrinergic agonist (cardioselective) tx-cardiogenic shock, heart failure  
Terbutaline   Beta 2 adrinergic agonist Tx- asthma, emphysema  
Isoproteronol   Beta 1 and 2 adrinergic agonist (not cardioselective)  
Milnirone   phosphodiesterase inhibitor (results in incresed Ca++ release) tx-heart failure, pulmonary problems  
Brimonidine   sympathomimetic - alpha 2 agonist tx. HT  
Norephinephrine   alpha 1 agonist - vasoconstrictor tx-hypovolemia  
prazosin   aplha 1 blocker (causes vasodilation) tx-HT  
Clonidine   alpha 2 antagonist - sympatholytic - tx-HT  
Furosemide   Diuretic - decr. blood volume tx-HT, edema, CHF, renal failure  
positive inotropes   increase contractility to increase BP (classes: Beta adrinergic and dopamine agonists) tx-circulatory shock  
mecamylamine   ganglionic blocker, nicotinic antagonist tx-severe hypertension (crisis), BP control during aortic surgery  
Tolcapone   COMT inhibitor - leads to incr. brain [dopamine] tx-parkinsons  
Verapamil   Ca++ channel blocker (most potent negative chronotrope, inotrope, dromotrope) tx-hypertension  
Propanolol   B1 and B2 blocker (noncardioselective w/o ISA)  
Zafirlukast   long acting bronchodilator (anti-inflammatory) blocks leukotriene receptors. tx-asthma  
Montelukast   long acting bronchodilator (antiinflammatory), leukotriene antagonist tx-asthma  
Salmeterol   long acting bronchodilator, B2 agonist, tx-asthma  
Pindolol   B1 and 2 blocker (noncardiselective w/ISA)  
Atenolol   B1 blocker (cardioselective w/o ISA)  
Acebutolol   B1 blocker (cardioselective w/ISA)  
Propanolol   B1 and B2 blocker (NON cardioselective) tx-HT  
Atropine   Anthicholinergetic (muscarinic antagonist) tx-produce mydriasis, decr. airway secretions during intubation  
Tolterodine   anticholinergic (muscarininc antagonist) tx-overactive bladder  
Sites of adrinergic drug action (6)   1. synthesis 2. vesicular packaging 3. release 4. receptor binding 5. re-uptake 6. metabolism  
Metyrosine   blocks synthesis of NE tx-pheocromacytoma (causes HT)  
Reserpine   blocks vesicular packaging of NE tx-Ht  
Desipramine   TriCyclicAntidepressant: blocks reuptake of NE tx-depression  
Isocarboxazid   MAO inhibitor: inactivates excessice neurotransmitters tx-depression  
Demecarium   cholinergic (indirect) agonist - inhibits acetylcholinesterase tx-myasthenia gravis, open angle glaucoma  
Ambenonium   chlinergic (indirect) agonist - inhibits acetylcholinesterase tx-myasthenia gravis, glaucoma  
Pilocarpine   Cholinomimetic (Ach agonist) Tx-occular HT, glaucoma  
Albuterol   B agonist: rapid acting bronchodilator tx-asthma  
Ipratropium bromide   Anticholinergic - rapid acting bronchodilator Tx-asthma  
Pancuronium   ganglionic blocker, Ach antagonist Tx-hypertensive crisis, control in surgery on aortic aneurism/surgery on blood vessels  
cardiac effects of Ach   parasympathetic response (decr. HR, Decr. contractility) MOA-activation of K+ channels, inhibittion of Ca++ channels, adenylyl cyclase  
Cardiac effects of NE/Epi   sypathetic response - incr. HR, inr. contractility MOA - activate adenyly cyclase, activate Ca++ channels  
Sundilac   anaglesic, antipyretic, anti-inflammatory. Active sulfide metabolite.  
Ketorolac   analgesic in ER for suspected opiod users, available in parenteral form  
DMARD stands for?   Disease Modifying Anti Rheumatoid arthritis Drugs  
Methotrexate   synthetic DMARD. Tx-RA  
Infliximab   biological DMARD, inhibits TNF-alpha (inflammatory mediator)  
Anakinra   inhibits IL-1 tx-RA  


   





 
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Created by: igelderloos on 2004-12-12



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