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Drugs for Block II

Cardioactive, Vasoactive, Sympathomimetics, Sympatholytics

Drug NameClass/Effects/Action
Phenylephrine sympathomimetic (alpha-1 agonist) tx-HT, nasal congestion
Beclomethasone corticosteroid - inhaled (less systemic side effects)
Clonidine sympathomimetic - alpha 2 agonist. tx-HT
Theophylline long acting bronchodilator (phosphodiesterase inhibitor) tx-asthma
Terbutaline sympathomimetic - beta 2 agonist. tx-asthma, emphysema
Metoprolol sympatholytic - beta 1 blocker (agonist) tx-HT
Yohimbine sympatholytic - alpha 2 antgonist. tx-erectile dys. produce mydriasis
prazosin sympatholytic - alpha 1 blocker (antagonist) tx-HT
Dobutamine sympathomimetic - beta 1 agonist. tx-cardiac decomposition
Fluticasone corticosteroid (inhaled) - less systemic side effects
Prednisone corticosteroid (systemic)
Four classes of long acting bronchodilators 1. inflammatory mediators inhibitor 2. beta adrinergic agonists 3. leukotriene antagonists 4. phosphodiesterase inhibitors
mediators that actively constrict smooth muscle (4) histamine, seratonin, platelet activating factor, leukotrienes
receptors that NE and Epi act on beta 1 and 2; alpha 1 and 2 adrinergic receptors
receptors that Ach acts on & ultimate effect in the airway M1 and M2 receptors (smooth muscle contraction in airway)
Digoxin cardiac glycoside - increases contractlity by increasing intracellular [Ca++] tx-heart failure
Dopamine Dopamine agonist low doses: incr. CO, TPR, venous tone. High doses: incr. TPR, pulmonary vascular resistance, produces vasoconstriction
positive inotropes improve cardiac function by increasing contractility. drug classes: beta adrinergic, dopamine agonists, phosphodiesterase inhibitors, cardiac glycosides tx-heart failure
cardiac antihypertensives decrease afterload of heart. beta blockers, Ca++ channel blockers tx-HT, heart failure
beta adrinergic agonists - prototype drugs (3) isoproteronol (B1 and 2), Dobutamine (B1), Terbutaline (B2)
Dobutamine Beta 1 adrinergic agonist (cardioselective) tx-cardiogenic shock, heart failure
Terbutaline Beta 2 adrinergic agonist Tx- asthma, emphysema
Isoproteronol Beta 1 and 2 adrinergic agonist (not cardioselective)
Milnirone phosphodiesterase inhibitor (results in incresed Ca++ release) tx-heart failure, pulmonary problems
Brimonidine sympathomimetic - alpha 2 agonist tx. HT
Norephinephrine alpha 1 agonist - vasoconstrictor tx-hypovolemia
prazosin aplha 1 blocker (causes vasodilation) tx-HT
Clonidine alpha 2 antagonist - sympatholytic - tx-HT
Furosemide Diuretic - decr. blood volume tx-HT, edema, CHF, renal failure
positive inotropes increase contractility to increase BP (classes: Beta adrinergic and dopamine agonists) tx-circulatory shock
mecamylamine ganglionic blocker, nicotinic antagonist tx-severe hypertension (crisis), BP control during aortic surgery
Tolcapone COMT inhibitor - leads to incr. brain [dopamine] tx-parkinsons
Verapamil Ca++ channel blocker (most potent negative chronotrope, inotrope, dromotrope) tx-hypertension
Propanolol B1 and B2 blocker (noncardioselective w/o ISA)
Zafirlukast long acting bronchodilator (anti-inflammatory) blocks leukotriene receptors. tx-asthma
Montelukast long acting bronchodilator (antiinflammatory), leukotriene antagonist tx-asthma
Salmeterol long acting bronchodilator, B2 agonist, tx-asthma
Pindolol B1 and 2 blocker (noncardiselective w/ISA)
Atenolol B1 blocker (cardioselective w/o ISA)
Acebutolol B1 blocker (cardioselective w/ISA)
Propanolol B1 and B2 blocker (NON cardioselective) tx-HT
Atropine Anthicholinergetic (muscarinic antagonist) tx-produce mydriasis, decr. airway secretions during intubation
Tolterodine anticholinergic (muscarininc antagonist) tx-overactive bladder
Sites of adrinergic drug action (6) 1. synthesis 2. vesicular packaging 3. release 4. receptor binding 5. re-uptake 6. metabolism
Metyrosine blocks synthesis of NE tx-pheocromacytoma (causes HT)
Reserpine blocks vesicular packaging of NE tx-Ht
Desipramine TriCyclicAntidepressant: blocks reuptake of NE tx-depression
Isocarboxazid MAO inhibitor: inactivates excessice neurotransmitters tx-depression
Demecarium cholinergic (indirect) agonist - inhibits acetylcholinesterase tx-myasthenia gravis, open angle glaucoma
Ambenonium chlinergic (indirect) agonist - inhibits acetylcholinesterase tx-myasthenia gravis, glaucoma
Pilocarpine Cholinomimetic (Ach agonist) Tx-occular HT, glaucoma
Albuterol B agonist: rapid acting bronchodilator tx-asthma
Ipratropium bromide Anticholinergic - rapid acting bronchodilator Tx-asthma
Pancuronium ganglionic blocker, Ach antagonist Tx-hypertensive crisis, control in surgery on aortic aneurism/surgery on blood vessels
cardiac effects of Ach parasympathetic response (decr. HR, Decr. contractility) MOA-activation of K+ channels, inhibittion of Ca++ channels, adenylyl cyclase
Cardiac effects of NE/Epi sypathetic response - incr. HR, inr. contractility MOA - activate adenyly cyclase, activate Ca++ channels
Sundilac anaglesic, antipyretic, anti-inflammatory. Active sulfide metabolite.
Ketorolac analgesic in ER for suspected opiod users, available in parenteral form
DMARD stands for? Disease Modifying Anti Rheumatoid arthritis Drugs
Methotrexate synthetic DMARD. Tx-RA
Infliximab biological DMARD, inhibits TNF-alpha (inflammatory mediator)
Anakinra inhibits IL-1 tx-RA
Created by: igelderloos on 2004-12-12



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