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cytochromes

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
Alcool (chronique)   Induit CYP2E1  
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Alcool (non chronique)   Inhibe CYP2E1  
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Analgésiques (codéine)   Substrat CYP2D6, CYP3A4  
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Anesthésiques   Substrat CYP2E1  
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Antiarrhytmiques   Substrat CYP3A4  
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Antibiotiques   Substrat CYP3A4  
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Antidépresseurs   Substrat CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4  
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Antiépileptiques   Substrat CYP3A4  
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Anti-inflammatoires non stéroïdiens   Substrat CYP2C9  
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Antimalariens   Substrat CYP3A4  
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Antinéoplasiques   Substrat CYP3A4  
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Antiparkinsoniens   Substrat CYP3A4  
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Antipsychotiques   Substrat CYP1A2, CYP2D6, CYP3A4  
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Antirejets   Substrat CYP3A4  
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Antiviraux   Substrat CYP3A4  
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Benzo (sauf Lorazépam, oxazépam, témazépam)   Substrat CYP3A4  
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Bloqueurs de AT2   Substrat CYP2C9  
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Bloqueurs des canaux calciques   Substrat CYP3A4  
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Bupropion   Inhibe CYP2D6  
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Cimétidine   Inhibe CYP2D6  
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Ciprofloxacine   Inhibe CYP1A2, CYP3A4  
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Clarithromycine   Inhibe CYP3A4  
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CYP1A2 : Affinité?   Faible affinité/forte capacité  
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CYP2C9 : Affinité?   Forte affinité/faible capacité  
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CYP2D6 : Affinité?   Forte affinité/faible capacité  
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CYP3A4 : Affinité?   Faible affinité/forte capacité  
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Diabète non contrôlé   Induit CYP2E1  
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Diltiazem   Inhibe CYP3A4  
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Disulfiram   Inhibe CYP2E1  
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Érythromycine   Inhibe CYP3A4  
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Fluconazole   Inhibe CYP2C9  
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Fluoxétine   Inhibe CYP2D6  
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Fluvoxamine   Inhibe CYP1A2, CYP2C9, CYP2C19  
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Hypoglycémiants oraux   Substrat CYP2C9  
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Indinavir   Inhibe CYP3A4  
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Inhibiteurs de la HMG-CoA   Substrat CYP3A4  
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Inhibiteurs de la transcriptase inverse   Substrat CYP3A4  
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IPP   Substrat CYP2C19  
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Isoniazide (première dose)   Inhibe CYP2E1  
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Isoniazide (prise régulière)   Induit CYP2E1  
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Itraconazole   Inhibe CYP3A4  
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Kétoconazole   Inhibe CYP3A4  
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Macrolides   Substrat CYP3A4  
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Mexilétine   Inhibe CYP1A2  
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Néfazodone   Inhibe CYP3A4  
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Norfluoxétine   Inhibe CYP2D6, CYP3A4  
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Obésité   Induit CYP2E1  
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Paroxétine   Inhibe CYP2D6  
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Propafénone   Inhibe CYP1A2  
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Quinidine   Inhibe CYP2D6  
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Ritonavir   Inhibe CYP2C9, CYP2D6, CYP3A4  
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Rx cardiovasculaires   Substrat CYP2D6  
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Stéroïdes (cortisone)   Substrat CYP3A4  
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Sulfaphénazole   Inhibe CYP2C9  
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Tabagisme   Induit CYP2E1  
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Thiazolidiediones (Glitazones)   Substrat CYP2C8  
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Ticlopidine   Inhibe CYP2C19  
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Triptans   Substrat CYP3A4  
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