Chapter 2: The Digestive System: Mechanism for Nourishing the Body
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Main structures of the digestive system? | oral cavity
esophagus
stomach
small & large intestine
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Accessory organs | pancreas
liver
gallbladder
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4 layers of the lumen (tubular part of the intestine) | mucosa
submuscosa
muscularis externa
serosa or adventitia
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Mucosa | inner most layer of lumen
interacts with food the most
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Submucosa | connective tissue
also has submucosal plexus
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Submucosal plexus | part of the submucosa that is part of the eneteric nervous system controlling digestion
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Muscularis externa | circulartory muscle (circular and longitudnal smooth muscle)
myentaeric plexus
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Myentaric Plexus | part of the enteric nervou systemt hat controls digestion
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Composition of the oral cavity | mouth and pharynx
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What are the organs of the oral cavity? | mouth
pharynx
salivary glands
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Types of salivary glands | parotid
submandibular
sublingual
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Salivary glands are the first level of what? | chemical digestion using amylases (MAIN source)
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What is in saliva? | Enzymes that help to breakdown and santize foods
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Main enzyme in saliva? | amylase
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Function of the esophagus | moves bolus from oral cavity to stomach
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Swallowing is what and occurs where? | moving the bolus down and in the esophogus
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What are the 3 types of swallowing? | voluntary
pharyngeal
esophageal (larynx causes epiglottis to cover the glottis)
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Peristalsis is what and where does it occur? | waves moving food down
the esophagus
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Gastroesophageal sphincter | connects the esophagus to the stomach
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Example of a disease of the esophagus | gastrointestinal intestinal disease (GERD)
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Is swallowing dependent on gravity? | NO!
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Bolus | cewed food and saliva
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4 main regions of the stomach | cardia
fundus
body
antrum (distal pyloric region)
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Cardia region | GE sphincter
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Fundus | top part
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Antrum (DPR) | bottom; between stomach and SI
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Function of DPR | grinds food and mixes with gastric juices to form chyme
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DPR uses what to move chyme? | peristalsis
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Volume of stomach full and empty? | empty: 50mL
full: 1L
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How much saliva is produced each day? | ~1L
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What percentage of saliva is water? | 99%
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function of saliva? | dissolves and lubricates food
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What does saliva contain? | antibacterial and antiviral components
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What does GERD result from? | gastric acid entering the esophagus
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What are some potential precipitators? | smoking, chocolate, peppermint, alcohol, and peppermint cause sphincter to relax
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If you are prone to GERD, what should you avoid? | precipitating foods and laying down after eating
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Gastric glands of the stomach | cardiac
oxyntic
pyloric
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Cells in glands | neck (mucus) cells
parietal (oxyntic) cells
chief (peptic or zymogenic cells
enteroendocrine cells
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Neck (mucus) cells | mucus forms barrier around tissue to prevent acid harm
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Parietal (oxyntic) cells | secrete acid to activate the enzyme pepsinogen and secretes intrinsic facotr which binds to B12 for absorption
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Chief (peptic or zymogenic) cells | secrete enzymes pepsinongen and breaks down proteins a little but not much
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Enteroendocrine cells | secretes hormones in blood
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Active state of pepsin | pepsinogen
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composition of gastric juice | HCl
enzymes
mucus
intrinsic factor
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Gastric juices are made up of HCl for these reasons | converts pepsinogen to pepsin
denatures proteins
releases nutrients from organic complexes
acts as bacteriocide
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Denaturing of acid proteinss | acid connections become more linear and pepsinogen can cleave in
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Release of organic complexes | form an ionic bond from food to release nutrient
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Enzymes in the stomach | some amylase (not much)
pepsin
lipase
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Mucus | provides about 2mm of pr?otection from acid
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Why is there amylase in the stomach? | it travels with the saliva
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What limited chemical digestion takes place in the stomach? | -initiation of protein synthesis
-limited continuation of starch hydrolysis
-absorption of water, alcohol, and a few drugs and minerals
-HCl important for iron and IF for B12
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What is HCl important for? | iron
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What is IF (intrinsic factor) important for? | B12 absorption
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Hormones and peptide that INHIBIT gastric secretion. | PYY, GIP, secretin, somatostatin
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Hormones and peptides that STIMULATE gastric secretion. | gastrin releasing peptide
gastrin
HCl
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What is the release of HCl stimulated by? | gastrin, acetylcholine, histamine
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Cause of peptic ulcers | H. Pylori
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Treatment of peptic ulcers | H2 blocker= (pepcid/zantac) antagonize signals of histamine
OR
Proton Pump Inhibitors: (priolosec) inhibit HCl by binding receptor
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H. Pylori | bacteria that's acid resistant and a cause of peptic ulcers
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What can disrupt the mucus barrier? | aspirin, alcohol, ibuprofen,
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The small intestine was made to do what? | maximize surface area to increase absorption
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Structural aspects of SI | folds of Kerckring
Villi
microvilli
brush border
crypts of Lieberkuhn
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Folds of Kerckring | large circular folds of mucosa
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Villi | at the end of the folds of Kerckring;
finger-like projections
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Microvilli | hair-like extensions of the cells' plasma membranes
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Crypts of Lieberkuhn | in between villi and replace the old villi
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Enterocytes in the SI are replaced? | every 3-5 days
they are slothed off and digested, which from that, the nutrients are used to make a new one!
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What is the relaxation reflex of the stomach? | controlled by vagud nerve
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Some people use a ____ to control contractions | pacemaker
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What causes ____ contractions that move from fundus to antrum? | myoelectric complex complex; wave-like
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What is the release of chyme regulated by? | volume and osmolarity
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Overall gastric emptying takes how long? | 2-6 hours
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When chyme leaves the stomach it goes where? | through to the pyloric sphincter
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The SI is the main site of what? | digestion and absoption
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What are the sections of the small intestine? | duodenum
jejunum
ileum
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What increases intestinal secretions and motility? | vasoactive intestinal polypeptide (VIP)
neuropeptide substance P, Motlin, CCK
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Where are vasoactive intestinal polypeptides found? | in neurons within the gut
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What decreases intestinal secretions and motility? | PYY, secretin, glucagon-like peptides
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What are the 2 tissues that help to protect the GI tract? | MALT (mucus)
GALT (gut)
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What is the pancreas? | ductless endocrine cells that secrete hormones into the blood
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The pancreas contains what type of enzymes? | digestive that are produced by acinar exocrine cells
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Pancreatic juices contain | bicarbonate
electrolytes
pancreatic digestive enzymes
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Contractions of the SI | segmentation and peristaltic waves
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Segmentation | alternating contractions of circular smooth muscles, which breaks down and mixes intestinal contents
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Peristaltic waves | progressive contractions that move SI contents distally though the SI and toward the LI
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