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Chapter 2: The Digestive System: Mechanism for Nourishing the Body

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Question
Answer
Main structures of the digestive system?   oral cavity esophagus stomach small & large intestine  
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Accessory organs   pancreas liver gallbladder  
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4 layers of the lumen (tubular part of the intestine)   mucosa submuscosa muscularis externa serosa or adventitia  
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Mucosa   inner most layer of lumen interacts with food the most  
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Submucosa   connective tissue also has submucosal plexus  
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Submucosal plexus   part of the submucosa that is part of the eneteric nervous system controlling digestion  
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Muscularis externa   circulartory muscle (circular and longitudnal smooth muscle) myentaeric plexus  
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Myentaric Plexus   part of the enteric nervou systemt hat controls digestion  
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Composition of the oral cavity   mouth and pharynx  
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What are the organs of the oral cavity?   mouth pharynx salivary glands  
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Types of salivary glands   parotid submandibular sublingual  
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Salivary glands are the first level of what?   chemical digestion using amylases (MAIN source)  
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What is in saliva?   Enzymes that help to breakdown and santize foods  
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Main enzyme in saliva?   amylase  
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Function of the esophagus   moves bolus from oral cavity to stomach  
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Swallowing is what and occurs where?   moving the bolus down and in the esophogus  
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What are the 3 types of swallowing?   voluntary pharyngeal esophageal (larynx causes epiglottis to cover the glottis)  
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Peristalsis is what and where does it occur?   waves moving food down the esophagus  
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Gastroesophageal sphincter   connects the esophagus to the stomach  
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Example of a disease of the esophagus   gastrointestinal intestinal disease (GERD)  
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Is swallowing dependent on gravity?   NO!  
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Bolus   cewed food and saliva  
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4 main regions of the stomach   cardia fundus body antrum (distal pyloric region)  
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Cardia region   GE sphincter  
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Fundus   top part  
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Antrum (DPR)   bottom; between stomach and SI  
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Function of DPR   grinds food and mixes with gastric juices to form chyme  
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DPR uses what to move chyme?   peristalsis  
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Volume of stomach full and empty?   empty: 50mL full: 1L  
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How much saliva is produced each day?   ~1L  
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What percentage of saliva is water?   99%  
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function of saliva?   dissolves and lubricates food  
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What does saliva contain?   antibacterial and antiviral components  
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What does GERD result from?   gastric acid entering the esophagus  
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What are some potential precipitators?   smoking, chocolate, peppermint, alcohol, and peppermint cause sphincter to relax  
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If you are prone to GERD, what should you avoid?   precipitating foods and laying down after eating  
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Gastric glands of the stomach   cardiac oxyntic pyloric  
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Cells in glands   neck (mucus) cells parietal (oxyntic) cells chief (peptic or zymogenic cells enteroendocrine cells  
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Neck (mucus) cells   mucus forms barrier around tissue to prevent acid harm  
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Parietal (oxyntic) cells   secrete acid to activate the enzyme pepsinogen and secretes intrinsic facotr which binds to B12 for absorption  
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Chief (peptic or zymogenic) cells   secrete enzymes pepsinongen and breaks down proteins a little but not much  
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Enteroendocrine cells   secretes hormones in blood  
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Active state of pepsin   pepsinogen  
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composition of gastric juice   HCl enzymes mucus intrinsic factor  
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Gastric juices are made up of HCl for these reasons   converts pepsinogen to pepsin denatures proteins releases nutrients from organic complexes acts as bacteriocide  
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Denaturing of acid proteinss   acid connections become more linear and pepsinogen can cleave in  
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Release of organic complexes   form an ionic bond from food to release nutrient  
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Enzymes in the stomach   some amylase (not much) pepsin lipase  
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Mucus   provides about 2mm of pr?otection from acid  
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Why is there amylase in the stomach?   it travels with the saliva  
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What limited chemical digestion takes place in the stomach?   -initiation of protein synthesis -limited continuation of starch hydrolysis -absorption of water, alcohol, and a few drugs and minerals -HCl important for iron and IF for B12  
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What is HCl important for?   iron  
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What is IF (intrinsic factor) important for?   B12 absorption  
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Hormones and peptide that INHIBIT gastric secretion.   PYY, GIP, secretin, somatostatin  
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Hormones and peptides that STIMULATE gastric secretion.   gastrin releasing peptide gastrin HCl  
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What is the release of HCl stimulated by?   gastrin, acetylcholine, histamine  
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Cause of peptic ulcers   H. Pylori  
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Treatment of peptic ulcers   H2 blocker= (pepcid/zantac) antagonize signals of histamine OR Proton Pump Inhibitors: (priolosec) inhibit HCl by binding receptor  
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H. Pylori   bacteria that's acid resistant and a cause of peptic ulcers  
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What can disrupt the mucus barrier?   aspirin, alcohol, ibuprofen,  
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The small intestine was made to do what?   maximize surface area to increase absorption  
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Structural aspects of SI   folds of Kerckring Villi microvilli brush border crypts of Lieberkuhn  
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Folds of Kerckring   large circular folds of mucosa  
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Villi   at the end of the folds of Kerckring; finger-like projections  
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Microvilli   hair-like extensions of the cells' plasma membranes  
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Crypts of Lieberkuhn   in between villi and replace the old villi  
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Enterocytes in the SI are replaced?   every 3-5 days they are slothed off and digested, which from that, the nutrients are used to make a new one!  
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What is the relaxation reflex of the stomach?   controlled by vagud nerve  
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Some people use a ____ to control contractions   pacemaker  
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What causes ____ contractions that move from fundus to antrum?   myoelectric complex complex; wave-like  
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What is the release of chyme regulated by?   volume and osmolarity  
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Overall gastric emptying takes how long?   2-6 hours  
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When chyme leaves the stomach it goes where?   through to the pyloric sphincter  
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The SI is the main site of what?   digestion and absoption  
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What are the sections of the small intestine?   duodenum jejunum ileum  
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What increases intestinal secretions and motility?   vasoactive intestinal polypeptide (VIP) neuropeptide substance P, Motlin, CCK  
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Where are vasoactive intestinal polypeptides found?   in neurons within the gut  
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What decreases intestinal secretions and motility?   PYY, secretin, glucagon-like peptides  
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What are the 2 tissues that help to protect the GI tract?   MALT (mucus) GALT (gut)  
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What is the pancreas?   ductless endocrine cells that secrete hormones into the blood  
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The pancreas contains what type of enzymes?   digestive that are produced by acinar exocrine cells  
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Pancreatic juices contain   bicarbonate electrolytes pancreatic digestive enzymes  
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Contractions of the SI   segmentation and peristaltic waves  
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Segmentation   alternating contractions of circular smooth muscles, which breaks down and mixes intestinal contents  
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Peristaltic waves   progressive contractions that move SI contents distally though the SI and toward the LI  
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