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PCSOM Block 4
Drug Classes/Drugs/MOAs
Drug Class | Drug | Mech of Action |
---|---|---|
Natural Penicillins | Penicillin G | Cell Wall Inhibitor, Beta-Lactam antibiotic |
Natural Penicillins | Penicillin V | Cell Wall Inhibitor, Beta-Lactam antibiotic |
Antistaph Penicillins | Methicillin | Cell Wall Inhibitor, Beta-Lactam antibiotic |
Antistaph Penicillins | Nafcillin | Cell Wall Inhibitor, Beta-Lactam antibiotic |
Amino Penicillins | Ampicillin | Cell Wall Inhibitor, Beta-Lactam antibiotic |
Amino Penicillins | Amoxicillin | Cell Wall Inhibitor, Beta-Lactam antibiotic |
Antipseudomonal Penicillins | Piperacillin | Cell Wall Inhibitor, Beta-Lactam antibiotic |
Antipseudomonal Penicillins | Carbenicillin | Cell Wall Inhibitor, Beta-Lactam antibiotic |
Antipseudomonal Penicillins | Ticarcillin | Cell Wall Inhibitor, Beta-Lactam antibiotic |
Antipseudomonal Penicillins | Mezlocillin | Cell Wall Inhibitor, Beta-Lactam antibiotic |
1st Gen Ceph | cefazolin | Bactericidal; Inactivate PBPs, Prevent crosslinkage formation; Allow autolysins to proceed |
1st Gen Ceph | Cephalexin | Bactericidal; Inactivate PBPs, Prevent crosslinkage formation; Allow autolysins to proceed |
2nd Gen Ceph | Cefaclor | Bactericidal; Inactivate PBPs, Prevent crosslinkage formation; Allow autolysins to proceed |
2nd Gen Ceph | Cefoxitin | Bactericidal; Inactivate PBPs, Prevent crosslinkage formation; Allow autolysins to proceed |
2nd Gen Ceph | Cefuroxime | Bactericidal; Inactivate PBPs, Prevent crosslinkage formation; Allow autolysins to proceed |
2nd Gen Ceph | Cefamandole | Bactericidal; Inactivate PBPs, Prevent crosslinkage formation; Allow autolysins to proceed |
3rd Gen Ceph | Cefoperazone | Bactericidal; Inactivate PBPs, Prevent crosslinkage formation; Allow autolysins to proceed |
3rd Gen Ceph | Cefotaxime | Bactericidal; Inactivate PBPs, Prevent crosslinkage formation; Allow autolysins to proceed |
3rd Gen Ceph | Ceftazidime | Bactericidal; Inactivate PBPs, Prevent crosslinkage formation; Allow autolysins to proceed |
3rd Gen Geph | Ceftriaxone | Bactericidal; Inactivate PBPs, Prevent crosslinkage formation; Allow autolysins to proceed |
4th Gen Ceph | Cefepime | Bactericidal; Inactivate PBPs, Prevent crosslinkage formation; Allow autolysins to proceed |
Carbapenems | Imipenem | Bactericidal; Inactivate PBPs, Prevent crosslinkage formation; Allow autolysins to proceed |
Carbapenems | Meropenem | Bactericidal; Inactivate PBPs, Prevent crosslinkage formation; Allow autolysins to proceed |
Carbapenems | Ertapenem | Bactericidal; Inactivate PBPs, Prevent crosslinkage formation; Allow autolysins to proceed |
Monobactams | Aztreonam | Bactericidal; Inactivate PBPs, Prevent crosslinkage formation; Allow autolysins to proceed |
Other: Affecting Cell Wall | Vancomycin | Glycopeptide inhibits cell wall synthesis by preventing peptidoglycan elongation; bactericidal; bacteriostatic for enterococci |
Other: Affecting Cell Wall | Teicoplanin | (blank) |
Other: Affecting Cell Wall | Bacitracin | (blank) |
Other: Affecting Cell Wall | Polymyxin | (blank) |
Tetracyclines | Tetracycline | Bacteriostatic; Blocks protein synthesis by binding to 30S ribosomal subunit & blocking access of amino acyl-tRNA to mRNA ribosome complex at acceptor site. Prevents addition of amino acids to growing peptide. |
Tetracyclines | Doxycycline | Bacteriostatic; Blocks protein synthesis by binding to 30S ribosomal subunit & blocking access of amino acyl-tRNA to mRNA ribosome complex at acceptor site. Prevents addition of amino acids to growing peptide. |
Aminoglycosides | Gentamicin (prototype) | Bactericidal; Entry of drugs into bacterial cells; Blocks Protein synthesis at 30S |
Aminoglycosides | Amikacin | Bactericidal; Entry of drugs into bacterial cells; Blocks Protein synthesis at 30S |
Aminoglycosides | Streptomycin | Bactericidal; Entry of drugs into bacterial cells; Blocks Protein synthesis at 30S |
Macrolides | Erythromycin | Bacteriostatic; Blocks protein synthesis at 50S inhibiting aminoacyl translocation rxn |
Macrolides | Clarithromycin | Bacteriostatic; Blocks protein synthesis at 50S inhibiting aminoacyl translocation rxn |
Macrolides | Azithromycin | Bacteriostatic; Blocks protein synthesis at 50S inhibiting aminoacyl translocation rxn |
Other Protein Synthesis Inhibitors | Chloramphenicol | Binds to 50S and inhibits peptidyl transferase step of protein synthesis |
Other Protein Synthesis Inhibitors | Clindamycin | Binds to 50S and inhibits peptidyl transferase step of protein synthesis |
Other Protein Synthesis Inhibitors | Streptogramins (quinupristin & dalfopristin) | Bacteriostatic; blocks protein synthesis at 50S inhibiting aminoacyl translocation rxn |
Other Protein Synthesis Inhibitors | Linezolid | Bacteriostatic; blocks protein synthesis at 50S inhibiting aminoacyl translocation rxn |
Other Protein Synthesis Inhibitors | Telithromycin | Bacteriostatic; blocks protein synthesis at 50S inhibiting aminoacyl translocation rxn - binds 10x tighter |
Other | Metronidazole | Metabolized to active form by ferredoxin that inhibits DNA |
Other | Daptomycin | Binds to cell membrane causing rapid depolarization; loss of membrane potential inhibits protein, DNA & RNA synthesis |
Sulfonamides | Sulfacetamide | Bacteriostatis; Competes with PABA for dihydropteroate synthase & prevents synthesis of folic acid |
Sulfonamides | Silver Sulfadiazine | Bacteriostatis; Competes with PABA for dihydropteroate synthase & prevents synthesis of folic acid |
Sulfonamides | Trimethoprim-Sulfamethoxazole | inhibits dihydrofolate reductase blocking purine, pyrimidine & amono acid synthesis - synergistic preventing of formation of tetrahydrofolic acid |
Fluoroquinolones | Norfloxacin | Inhibition of topoisomerase II |
Fluoroquinolones | Ciprofloxacin | Inhibition of topoisomerase II |
Fluoroquinolones | Ofloxacin | Inhibition of topoisomerase II |
Fluoroquinolones | Gatifloxacin | Inhibition of topoisomerase II |
Fluoroquinolones | Levofloxacin | Inhibition of topoisomerase II |
Fluoroquinolones | Moxifloxacin | Inhibition of topoisomerase II |
Fluoroquinolones | Sparfloxacin | Inhibition of topoisomerase II |
Urinary Tract Antiseptic | Nitrofurantoin | Metabolized to active form by the bacteria inhibiting various enzymes & damages DNA |
Antigout Agent | Probenecid | Inhibits tubular reabsorption of uric acid increasing the urinary excretion of uric acid |