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DT261-Tetracylines

Tetracylines

TermDefinition
Tetracycline: Pharmacokinetics •All tetracyclines cross the placenta and enter fetal circulation •Secreted in the saliva and breast milk •Concentrated by the liver and excreted into the intestines via the bile •Enterohepatic circulation prolongs their action •Stored in dentin a
Tetracycline: Spectrum •Bacteriostatic •Interfere with synthesis of bacterial protein by binding at the 30S subunit of bacterial ribosomes Broad spectrum: •Effective against a wide variety of gram-positive and gram-negative bacteria •Bacterial resistance develops s
Tetracycline: Adverse Reactions •GI effects •Diarrhea •Staphylococcal enterocolitis •Intestinal candidiasis •Pseudomembranous colitis •Yellowish-brown discoloration of tongue •Candidiasis
Tetracycline: Effects on Teeth and Bones •Tetracycline can produce permanent discoloration and enamel hypoplasia •Decrease in growth rate of bones •Minocycline can cause black pigmentation of mandibular and maxillary alveolar bone and the hard palate
Tetracycline: Uses •Chlamydial and rickettsia infections •Treat acne •Pulmonary infections in patients with COPD •Traveler's diarrhea •Periodontal conditions •Concentrated in GCF (gingival crevicular fluid)
Created by: mbk2023
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