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Pain, Hema, Onco 2
Pain, Hema, Onco 2 Essential Knowledge
Generic/Brand | Side effects |
---|---|
Methotrexate/ Trexall (PO) KSE | Key Side Effects: stomatitis, diarrhea, nausea, vomiting, thrombocytopenia, leukopenia, increased hepatic transaminases, pulmonary fibrosis (rare). |
Methotrexate/ Trexall (PO) US WARN | Warn: toxic rxns (only use in life-threatening neoplastic disease, psoriasis, or severe rheumatoid arthritis); causes fetal death &/or congenital abnormal (avoid in pregnancy); severe fatal bone marrow suppression, aplastic anemia, & toxic reported w/concomitant administration of methotrexate and NSAIDs; causes hepatotoxicity; methotrexate-induced lung disease, including acute or chronic interstitial pneumonitis occurs; severe (sometimes fatal) GI toxicity reported w/ concominant administration w/NSAIDs. |
Methotrexate/ Trexall (PO) OTHER NOTES | Other Notes: folic acid supplementation may be taken during use to reduce hematologic, gastrointestinal, and hepatic side effects. |
Anastrozole/ Arimidex (PO) | Key Side Effects: fatigue, rash, flushing, hot flashes, arthralgia, nausea, vomiting, hypertension, peripheral edema, osteoporosis. Other Notes: cardiovascular side effects (i.e., hypercholesterolemia, CAD); fetal toxicity (CI in pregnancy). |
Phentermine/ Adipex-P (PO) | Key Side Effects: hypertension, nausea, dizziness, xerostomia, primary pulmonary hypertension (rare). Other Notes: only approved for short-term use; CI in those with a history of cardiovascular disease or drug abuse, pregnancy, hyperthyroidism, or within 14 days of MAOI inhibitor therapy. |
Ferrous Sulfate/ FeroSul, SlowFe (PO) | Key Side Effects: nausea, stomach upset, constipation (dose-related), dark and tarry stools. Boxed Warning: Accidental overdose of iron is leading cause of fatal poisoning in children under 6 years old. |
Cyanocobalamin Vitamin B12/ ---- (PO, IM, SL, intranasal) | Key Side Effects: no major side effects |
Folic acid/ --- (PO) | Key Side Effects: no major side effects |