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Pain, etc. 2
Pain, Hematology, and Oncology 2
Generic Name | Brand Name | Pharmacologic Category | Common Indications | Key Side Effects/Other Notes | US Boxed Warning | US Boxed Warning Cont. | US Boxed Warning Cont. | US Boxed Warning Cont. |
---|---|---|---|---|---|---|---|---|
methotrexate (PO) | Trexall | Antimetabolite (folic acid antagonist) | Rheumatoid arthritis, Crohn’s Disease, psoriasis, various hematologic and solid tumors | Key Side Effects: stomatitis, diarrhea, nausea, vomiting, thrombocytopenia, leukopenia, increased hepatic transaminases, pulmonary fibrosis (rare) Other Notes; LOOK AT THE BDK LIST - IT WOULDN'T FIT HERE | US Boxed Warning: serious toxic reactions (only use in life-threatening neoplastic disease, severe psoriasis, or severe rheumatoid arthritis); may cause fetal death and/or congenital abnormalities (avoid in pregnancy); | US Boxed Warning Cont. : severe (sometimes fatal) bone marrow suppression, aplastic anemia, and toxicity have been reported with concomitant administration of methotrexate and NSAIDs | US Boxed Warning Cont. : may cause hepatotoxicity; methotrexate-induced lung disease, including acute or chronic interstitial pneumonitis may occur; | US Boxed Warning Cont: severe (sometimes fatal) gastrointestinal toxicity has been reported with concomitant administration with NSAIDs |
anastrozole (PO) | Arimidex | Aromatase inhibitor | Hormone receptor-positive breast cancer | Key Side Effects: fatigue, rash, flushing, hot flashes, arthralgia, nausea, vomiting, hypertension, peripheral edema, osteoporosis Other Notes cardiovascular side effects (i.e., hypercholesterolemia, CAD); fetal toxicity (CI in pregnancy) | ||||
phentermine (PO) | Adipex-P | CNS stimulant | Obesity | Key Side Effects: hypertension, nausea, dizziness, xerostomia, primary pulmonary hypertension (rare) | Other Notes: only approved for short-term use; CI in those with a history of cardiovascular disease or drug abuse, pregnancy, hyperthyroidism, or within 14 days of MAOI inhibitor therapy | |||
ferrous sulfate (PO) * | FeroSul, SlowFe | Iron supplement | Iron deficiency anemia | Key Side Effects: nausea, stomach upset, constipation (dose-related), dark and tarry stools | US Boxed Warning: Accidental overdose of iron is leading cause of fatal poisoning in children under 6 years old | |||
cyanocobalamin (vitamin B12) (PO, IM, SL, intranasal) * | ------- | Water-soluble vitamin | Vitamin B12 deficiency (manifests as macrocytic anemia) | Key Side Effects: no major side effects | ||||
folic acid (PO) * | ------- | Water-soluble vitamin | Folic acid deficiency (manifests as macrocytic anemia), prevention of neural tube defects in pregnancy | Key Side Effects: no major side effects |