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MDA Blankenship
MDA-Midterm
DRUG | MDA | Indication |
---|---|---|
Physostigmine | Reversible cholinesterase Inhibitor | Glaucoma (tertiary amine) |
Neostigmine | Reversible cholinesterase Inhibitor | postoperative/post partum atony of GI tract or urinary bladder, Myasthenia gravis |
Diisopropylfluorophosphate (DFP) | Irreversible cholinesterase Inhibitor (binds to OH is esteric site) | pesticide/nerve gas (organophosphate) |
Echothiophate | Irreversible cholinesterase Inhibitor (binds to OH is esteric site) | Glaucoma (organophosphate) |
Pralidoxine (2PAM) | Cholesterase reactivator | binds to anionic site on cholinesterase to remove organophosphate |
Atropine | competitive, muscarinic antagonist | control GI sensitivity; decrease respitory secretion; increase HR (CNS excitation) |
Scopolamine | muscarinic antagonist | insomnia; preansthetic agent; motion sickness (CNS depressant) |
Quaternary amines: Propantheline, Clidinium | muscarinic antagonist | Periphery effects, decrease GI motility; antispasmotic No CNS side effects |
Homotropine, Tropicamide | muscarinic antagonist | dilation of the eye (Mydriatic Agents) |
Ipratropium Bromide | muscarinic antagonist | COPD (blocks bronchoconstriction) |
Mecamylamine | nicotinic antagonist (Ganglionic blocker) | severe hypertension |
Pancuronium Bromide, Atracurium, Mivacurium | Competative neuromuscular Junction blocker | general ansthetics; severe convulsions |
Succinylcholine | Non-Competative neuromuscular Junction blocker | general ansthetics; severe convulsions |
Norepinephrine (Levarterenol) | α1, α2, β1 agonist | primary cardiovascular effects |
Epinephrine | α1, α2, β1, β2 agonist | Cardiac stimulation, anaphylaxis, asthma |
Isoproterenol | β1, β2 agonist | Bronchodilator (reflex tachycardia) |
Dobutamine | Selective β1 agonist | Cardiac stimulant |
Dopamine (DA) | D1 agonist | |
Tyramine (also from aged food) | Indirect - replaces NE in the vesicle causing its release and response | NE effectsα1 vasoconstriction; β1 cardio stimulant (Amphetamine - crosses BBB) Tolerance due to lack of NE left |
Ephedrine | Indirect - Replaces NE and has direct β2 agonist properties | bronchodilator(crosses BBB) |
Pseudoephedrine | Indirect - optical isomer of Ephedrine - indirect releaser of NE | nasal decongestant (vasoconstriciton) |
Phenylpropanolamine | Indirect - looks allot line NE and EPI - indirect releaser | |
Methylphenidate | indirect releaser | ADHD; appetite suppression |
Cocaine | Indirect - NE and Epi reuptake blocker | |
Phenylaphrine | direct - selective α1 agonist | nasal decongestant spray (vasoconstriciton), induce mydriasis |
Clonidine | direct - selective α2 agonist | antihypertensive |
Metaproterenol, Terbutaline, Albuterol, Salmeterol | β2 agonist | bronchodilator; prevention of premature delivery, |
Prazosin | competitive reversible α1 antagonist | antihypertensive |
Phenoxybenzamine | Non-competitive irreversible α1, α2 antagonist | control BP during surgery; Reynaud's syndrome |
Propranolol | competitive β1, β2 antagonist | anti-hypertensive; anti-angina; anti-arrhythmic; thyrotoxicosis; Anti-anxiety |
Metoprolol | β1 antagonist | antihypertensive, can be used in asthma |
Labetulol, Carvedilol | α1, β1, β2 antagonist | antihypertensive |
Bethanechol | Muscarinic Agonist | postoperative/post partum atony of GI tract or urinary bladder |